Journal
MOLECULAR DIVERSITY
Volume 14, Issue 3, Pages 479-491Publisher
SPRINGER
DOI: 10.1007/s11030-010-9249-2
Keywords
Multicomponent reaction (MCR); Isocyanide; Thiolactone; Virtual library
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Funding
- University of Pittsburgh Drug Discovery Institute
- CMCR [U19AI068021]
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We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.
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