Article
Biochemistry & Molecular Biology
Victor V. Dotsenko, Alexander V. Aksenov, Anna E. Sinotsko, Ekaterina A. Varzieva, Alena A. Russkikh, Arina G. Levchenko, Nicolai A. Aksenov, Inna V. Aksenova
Summary: The Michael addition reaction between dithiomalondianilide and arylmethylidene Meldrum's acids, along with subsequent heterocyclization, was investigated. The study also looked into the factors affecting the composition of the obtained products. The structure of one of the products was confirmed through X-ray crystallography.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Nadia Sadou, Naouel Boufroua, Sophie Poulain-Martini, Elisabet Dunach, Samia Achouche-Bouzroura
Summary: A novel thiazolidinone derivative was synthesized via a three-component reaction, involving thiosemicarbazide, maleimide, and Meldrum's acid. The reaction conditions were optimized, and the best results were obtained with a specific ratio of raw materials and solvent, leading to high product yields and reduced reaction time.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Elfie S. Cavalli, Thomas Mies, Henry S. Rzepa, Andrew J. P. White, Philip J. Parsons, Anthony G. M. Barrett
Summary: An efficient two-step procedure for synthesizing pyrimidine nucleosides is described. Firstly, a series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared, followed by transacylation reaction to obtain uridine-5-carboxylic acid derivatives and related nucleosides.
Article
Chemistry, Organic
Boris Lichitsky, Valeriya G. Melekhina, Andrey N. Komogortsev, Vasily A. Migulin, Yulia Nelyubina, Artem N. Fakhrutdinov, Elena D. Daeva, Arkady A. Dudinov
Summary: An efficient one-pot method was developed for the synthesis of previously unknown furanoflavone derivatives, based on a telescoped multicomponent reaction. The synthesis features regiospecific formation of a distinctive core structure. The advantages include mild conditions, atom economy, and easy workup procedure, avoiding the need for chromatographic purifications.
Article
Chemistry, Organic
Andrey N. Komogortsev, Boris V. Lichitsky, Valeriya G. Melekhina
Summary: A one-pot approach was developed for the synthesis of substituted colchicine derivatives based on the telescoped multicomponent reaction of colchiceine, arylglyoxals, and Meldrum's acid. The regiospecific formation of a distinctive moiety is a key feature of this method. Advantages include the use of readily accessible starting materials, process simplicity, and easy isolation of the target products.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Oleksandr Kolomiiets, Alexander Tsygankov, Maryna N. Kornet, Aleksander A. Brazhko, Vladimir I. Musatov, Valentyn A. Chebanov
Summary: Peptidomimetics with a substituted imidazo[1,2-a ]pyridine fragment were synthesized using a combination of Groebke-Black-burn-Bienayme and Ugi reactions. The resulting products contained substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores, with four diversity points introduced from readily available starting materials. A focused compound library consisting of 20 Ugi products was prepared and screened for antibacterial activity.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Deepika Sahil, Ramalingam Thirumoorthi, Chandrakanta Dash
Summary: In this study, a copper(I)-bis(imino)pyridine-triphenylphosphine complex was successfully synthesized and characterized using various analysis methods. The complex exhibited a distorted tetrahedral geometry and was proven to be an effective catalyst for a one-pot multicomponent Click reaction in methanol, resulting in the synthesis of several 1,4-disubstituted 1,2,3-triazoles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhiwei Chen, Piaopiao Zeng, Shuo Zhang, Xiaoxiao Huang
Summary: A concise one-pot route for the synthesis of furo[3,2-c]-coumarins catalyzed by Zn(OTf)(2) has been reported, allowing for the easy generation of libraries of furocoumarin analogues through multicomponent tandem reactions. This transformation is highly atom economical and exhibits good functional group compatibility.
Review
Chemistry, Organic
Felix Brosge, Pardeep Singh, Fredrik Almqvist, Carsten Bolm
Summary: Meldrum's acid is a molecule with exceptional chemical properties, characterized by its low pK(a) value in water and reactivity in electrophilic and nucleophilic substitution reactions. At elevated temperatures, it undergoes distinctive decomposition pathways that can be used in cycloaddition and acylation reactions. Recent advances in utilizing Meldrum's acid derivatives in synthesis aim to further stimulate research towards innovative applications of this molecule.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nasrin Karami Hezarcheshmeh, Farideh Godarzbod, Media Noori Abdullah, Zinatossadat Hossaini
Summary: This research aims to synthesize novel pyrimidine triazole compounds efficiently using triethylamin as a catalyst. The newly synthesized compounds exhibit antioxidant and antibacterial properties, making them potentially valuable in various applications.
MOLECULAR DIVERSITY
(2023)
Review
Chemistry, Multidisciplinary
Ghodsi Mohammadi Ziarani, Dorsa Ebrahimi, Fatemeh Mohajer, Rajender S. Varma, Siavash Iravani
Summary: Multicomponent reactions (MCRs) are important in organic synthesis for their ability to efficiently construct complex structures in a single step. Meldrum's acid stands out as a versatile starting material in MCRs, offering a wide range of molecular diversity. This comprehensive review explores the scope of Meldrum's acid in various MCRs, emphasizing its unique attributes and environmentally friendly applications. Rating: 8/10.
Article
Chemistry, Multidisciplinary
Wei Liu, Tianren Qin, Wansen Xie, Jinmiao Zhou, Zidan Ye, Xiaoyu Yang
Summary: We have developed an efficient modular asymmetric synthesis of azahelicenes from readily available polycyclic aromatic amines, aldehydes, and (di)enamides, employing a central-to-helical chirality conversion strategy. A series of aza[5]- and aza[4]helicenes bearing various substituents were easily obtained with good yields and high enantioselectivities. The diverse derivatizations and the preliminary application of the azahelicene derivative as a chiral organocatalyst demonstrated the potential of this method, and the photophysical and chiroptical properties of these azahelicenes were well studied, showing potential applications in novel organic optoelectronic materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Martial Toffano, Regis Guillot, Chloee Bournaud, Jean-Francois Briere, Giang Vo-Thanh
Summary: A catalytic enantioselective vinylogous domino reaction has been successfully achieved, providing spirolactone dihydropyranones with high enantiomeric excess. The reaction involves an Auto Tandem Catalysis (ATC) process facilitated by the dual and complementary role of (DHQ)(2)PHAL organocatalyst, leading to good yields and high selectivity.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Kanji Niwa, Masao Ohashi, Kaili Xie, Chen-Yu Chiang, Cooper S. Jamieson, Michio Sato, Kenji Watanabe, Fang Liu, K. N. Houk, Yi Tang
Summary: We have discovered biosynthetic pathways that can produce and transform conjugated octaenes and nonaenes into complex natural products. The biosynthesis of (-)-PF1018 involves an enzyme called PfB, which controls the regio-, stereo-, and periselectivity of multiple reactions starting from a conjugated octaene. By using PfB as a starting point, we found a homologous enzyme, BruB, that facilitates diene isomerization, tandem 8π-6π-electrocyclization, and a 1,2-divinylcyclobutane Cope rearrangement to generate a novel compound not previously found in nature.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Abida Naseem Malik, Muhammad Nawaz Tahir, Akbar Ali, Muhammad Ashfaq, Muhammad Ibrahim, Aleksey E. Kuznetsov, Mohammed A. Assiri, Manal Y. Sameeh
Summary: The effective preparation of two new pyrimidine- and pyridine-based organic crystalline salts with substituted acidic moieties using methanol as a solvent has been reported. These molecular salts have ionic interactions responsible for their structural stabilization in solid-state assemblies. The crystal structures of the salts were determined and their noncovalent interactions were investigated.
Article
Chemistry, Multidisciplinary
Nikolay L. Babak, Oleg V. Shishkin, Svitlana V. Shishkina, Ivan M. Gella, Vladimir I. Musatov, Nataliya B. Novikova, Victoria V. Lipson
STRUCTURAL CHEMISTRY
(2016)
Article
Chemistry, Organic
Maria A. Vodolazhenko, Anastasiia E. Mykhailenko, Nikolay Yu. Gorobets, Sergey M. Desenko
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Dmitry V. Ziolkovskiy, Victoria V. Lipson, Anastasia D. Nikitina, Valentin A. Chebanov
LETTERS IN DRUG DESIGN & DISCOVERY
(2016)
Article
Chemistry, Organic
A. N. Semenenko, N. L. Babak, A. M. Eremina, I. M. Gella, S. V. Shishkina, V. I. Musatov, V. V. Lipson
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Organic
O. N. Petrova, V. V. Lipson, L. L. Zamigajlo, M. G. Shirobokova, V. I. Musatov, D. A. Dmitrienko
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Organic
Mustafa K. Gumus, Nikolay Yu. Gorobets, Yuriy V. Sedash, Svitlana V. Shishkina, Sergey M. Desenko
TETRAHEDRON LETTERS
(2017)
Article
Chemistry, Multidisciplinary
Hemandra Kumar Tiwari, Prashant Kumar, Nidhi Jatana, Krishan Kumar, Sandeep Garg, Latha Narayanan, Puran Singh Sijwali, Kailash Chand Pandey, Nickolay Yu Gorobets, Ben M. Dunn, Virinder Singh Parmar, Brajendra Kumar Singh
Article
Chemistry, Physical
Mustafa Kemal Gumus, Sevgi Kansiz, Ercan Aydemir, Nikolay Yu Gorobets, Necmi Dege
JOURNAL OF MOLECULAR STRUCTURE
(2018)
Article
Biochemistry & Molecular Biology
Mykola V. Protopopov, Olga V. Ostrynska, Sergiy A. Starosyla, Maria A. Vodolazhenko, Svetlana M. Sirko, Nikolay Yu. Gorobets, Volodymyr Bdzhola, Sergey M. Desenko, Sergiy M. Yarmoluk
MOLECULAR DIVERSITY
(2018)
Article
Crystallography
Mariia O. Shyshkina, Svitlana Shishkina, Konstantin S. Ostras, Nikolay Yu Gorobets, Valentyn A. Chebanov, Sergey M. Desenko
Summary: The coordination complex consists of a neutral tetrahydrotriazolopyrimidine derivative acting as a bridging ligand between two zinc molecules, resulting in polymeric chains. The zinc metal atom coordinates with the nitrogen atom of triazole and amino group, with the positive charge of the zinc atom being compensated by the chlorine anion and deprotonated acetic acid.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Oleg A. Zhikol, Svitlana Shishkina, Victoria V. Lipson, Alexander N. Semenenko, Alexander Mazepa, Alexander Borisov, Pavel Mateychenko
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Organic
Mustafa K. Gumus, Nikolay Yu. Gorobets, Yuriy V. Sedash, Valentin A. Chebanov, Sergey M. Desenko
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2017)
Review
Chemistry, Medicinal
Nikolay Yu. Gorobets, Yuriy V. Sedash, Brajendra K. Singh, Poonam, Brijesh Rathi
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Organic
Sergey A. Komykhov, Andrey A. Bondarenko, Vladimir I. Musatov, Mikhail V. Diachkov, Nikolay Yu. Gorobets, Sergey M. Desenko
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2017)
Article
Chemistry, Organic
Michael Kondratiuk, Nikolay Yu. Gorobets, Yuriy V. Sedash, Mustafa K. Guemues, Sergey M. Desenko
