Review
Oncology
Mohammad Taheri, Bashdar Mahmud Hussen, Sajad Najafi, Atefe Abak, Soudeh Ghafouri-Fard, Majid Samsami, Aria Baniahmad
Summary: ING genes are members of the tumor suppressor gene family and play important roles in regulating cell proliferation, apoptosis, and cellular senescence. They interact with chromatin structures and other proteins involved in biological processes such as cell cycle regulation, exerting their regulatory effects through epigenetic mechanisms. INGs have a role in restricting the proliferative and invasive potentials of normal cells and are particularly involved in cancer development and progression. However, further research and experimental confirmation are needed to validate these models.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Cell Biology
Dana L. Woodstock, Morgan A. Sammons, Martin Fischer
Summary: p53 and p63, as transcription factors, regulate both shared and unique target genes to exert their tumor suppressive or oncogenic effects. The previous notion of strict competition between the two siblings needs to be reevaluated, as they can also collaborate towards a common goal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pushpamala Ramaiah, Indrajit Patra, Anum Abbas, Ali Abdulhussain Fadhil, Mohammad Abohassan, Zahraa Haleem Al-qaim, Noora Mohammed Hameed, Moaed Emran Al-Gazally, Saif Sabbar Kemil Almotlaq, Yasser Fakri Mustafa, Yavar Shiravand
Summary: Mitofusin 2 (MFN2) is a critical regulator of mitochondrial fusion and function, playing a crucial role in the initiation and progression of cancer. It can act as a tumor suppressor, inducing cancer cell apoptosis and inhibiting cell proliferation, as well as an oncogene, promoting cancer invasion and tumorigenesis. Further research is needed to fully understand the mechanisms underlying the functions of MFN2 in cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Antonio Ferreira, Jon C. Aster
Summary: Notch receptors participate in a conserved signaling pathway that has diverse effects on normal cells and is highly dependent on the cellular context and signaling dosage. Notch plays different roles in various types of cancers, acting as either an oncogene or a tumor suppressor and affecting tumor cells and stromal elements in multiple ways. This review provides an overview of the roles of Notch in cancer and discusses the challenges and potential approaches for clinical translation of Notch targeting agents.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Genetics & Heredity
Eleni Nikolakaki, Ioanna Sigala, Thomas Giannakouros
Summary: SR protein kinases play a crucial role in mRNA splicing regulation and various cellular activities. SRPK1 can act as a tumor suppressor or promoter depending on the cellular context, while SRPK2 exhibits contradictory functions in different cell contexts. The subcellular localization of these kinases plays a critical role in determining cell response to external signals.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
He Fang, Hanyang Li, Hang Zhang, Shu Wang, Shuang Xu, Li Chang, Yongsheng Yang, Ranji Cui
Summary: This article summarises the significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers. It also describes the possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Beatrice Fontana, Giulia Gallerani, Irene Salamon, Ilaria Pace, Roberta Roncarati, Manuela Ferracin
Summary: ARID1A is a chromatin regulatory protein that plays a role in maintaining accessibility at promoters and enhancers to regulate gene expression. It is frequently altered in various human cancers and can act as a tumor suppressor or oncogene depending on the tumor type and context. ARID1A mutations are observed in approximately 10% of tumors, including endometrial, bladder, gastric, liver, biliopancreatic cancer, some ovarian cancer subtypes, and aggressive cancers of unknown primary. Its loss is generally associated with disease progression and worse prognostic features. However, the association of ARID1A genetic alterations with patient prognosis is controversial. Nevertheless, ARID1A loss of function can be targeted with inhibitory drugs based on synthetic lethality mechanisms.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Alberta Palazzo, Hector Hernandez-Vargas, Delphine Goehrig, Jean-Jacques Medard, David Vindrieux, Jean-Michel Flaman, David Bernard
Summary: Cancer cells arising from senescent cells display more aggressive features and resistance to drugs. A molecular signature of these cells can serve as a prognostic marker for several human cancers.
Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Biochemistry & Molecular Biology
Yichen Liu, Qiong Zhao, Tao Xi, Lufeng Zheng, Xiaoman Li
Summary: Metastasis refers to secondary tumor growth at a distant site from the primary tumor, which is closely linked to poor prognosis and mortality. miR-9 plays a dual role as a promoter or suppressor in cancer metastasis and is involved in coordinating multiple steps of the metastatic process. Studying the various mechanisms of miR-9 in regulating metastasis can facilitate further research and potentially inform clinical applications in the future.
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Bing Su, Wenyi Wei
Article
Oncology
Casey Stottrup, Tiffany Tsang, Y. Rebecca Chin
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Biochemistry & Molecular Biology
Jinfang Zhang, Kai Xu, Pengda Liu, Yan Geng, Bin Wang, Wenjian Gan, Jianping Guo, Fei Wu, Y. Rebecca Chin, Christian Berrios, Evan C. Lien, Alex Toker, James A. DeCaprio, Piotr Sicinski, Wenyi Wei
Article
Biochemistry & Molecular Biology
Gary K. Yiu, Aura Kaunisto, Y. Rebecca Chin, Alex Toker
BIOCHEMICAL JOURNAL
(2011)
Article
Oncology
Matthew Maurer, Tao Su, Lao H. Saal, Susan Koujak, Benjamin D. Hopkins, Christina R. Barkley, Jiaping Wu, Subhadra Nandula, Bhaskar Dutta, Yuli Xie, Y. Rebecca Chin, Da-In Kim, Jennifer S. Ferris, Sofia K. Gruvberger-Saal, Mervi Laakso, Xiaomei Wang, Lorenzo Memeo, Albert Rojtman, Tulio Matos, Jennifer S. Yu, Carlos Cordon-Cardo, Jorma Isola, Mary Beth Terry, Alex Toker, Gordon B. Mills, Jean J. Zhao, Vundavalli V. V. S. Murty, Hanina Hibshoosh, Ramon Parsons
Article
Oncology
Shiva Kazerounian, Damien Gerald, Minzhou Huang, Y. Rebecca Chin, Durga Udayakumar, Ningning Zheng, Rebekah K. O'Donnell, Carole Perruzzi, Lee Mangiante, Jacob Pourat, Thuy L. Phung, Arturo Bravo-Nuevo, Sharon Shechter, Stephanie McNamara, James B. DuHadaway, Olivier N. Kocher, Lawrence F. Brown, Alex Toker, George C. Prendergast, Laura E. Benjamin
Article
Oncology
Y. Rebecca Chin, Taku Yoshida, Andriy Marusyk, Andrew H. Beck, Kornelia Polyak, Alex Toker
Article
Biochemistry & Molecular Biology
Hiroyuki Inuzuka, Daming Gao, Lydia W. S. Finley, Wen Yang, Lixin Wan, Hidefumi Fukushima, Y. Rebecca Chin, Bo Zhai, Shavali Shaik, Alan W. Lau, Zhiwei Wang, Steven P. Gygi, Keiko Nakayama, Julie Teruya-Feldstein, Alex Toker, Marcia C. Haigis, Pier Paolo Pandolfi, Wenyi Wei
Article
Biochemistry & Molecular Biology
Y. Rebecca Chin, Alex Toker
Article
Biochemistry & Molecular Biology
Y. Rebecca Chin, Alex Toker
Article
Biochemistry & Molecular Biology
Daming Gao, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W. Locasale, Pengda Liu, Lixin Wan, Bo Zhai, Y. Rebecca Chin, Shavali Shaik, Costas A. Lyssiotis, Steven P. Gygi, Alex Toker, Lewis C. Cantley, John M. Asara, J. Wade Harper, Wenyi Wei
Article
Oncology
Y. Rebecca Chin, Xin Yuan, Steven P. Balk, Alex Toker
Review
Cell Biology
Y. Rebecca Chin, Alex Toker
CELL ADHESION & MIGRATION
(2011)
Article
Oncology
Tiffany Tsang, Qingling He, Emily B. Cohen, Casey Stottrup, Evan C. Lien, Huiqi Zhang, C. Geoffrey Lau, Y. Rebecca Chin
Summary: This study found that multiple receptor tyrosine kinases (RTKs) were hyperphosphorylated in Akt-inhibitor-resistant breast cancer cells, and the resistance could be overcome by an EGFR inhibitor. The study also revealed enhanced cancer stemness in resistant cells and identified several potential stem cell regulators that may contribute to acquired resistance.
