Article
Dermatology
Kyung-Il Kim, Kyung Eun Jung, Young-Bin Shin, Chang-Deok Kim, Tae-Jin Yoon
Summary: In this study, we conducted a large-scale screening test on drugs approved for other diseases to find pigmentation-modulating agents. Among the potential drugs, sorafenib was selected for further investigation on its effect on pigmentation in melanoma cells. The results showed that sorafenib promoted pigmentation by increasing the melanin content and tyrosinase activity. Mechanistic studies revealed that this effect was mediated by the activation of beta-catenin signaling through the regulation of GSK3 beta phosphorylation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Wen-Jing Zheng, Peng-Xiang Wang, Yun-Fan Sun, Jian-Wen Cheng, Yu-Chen Zhong, Yang Xu, Wei Guo, Bo Hu, Jian Zhou, Jia Fan, Xiang Chen, Xin-Rong Yang
Summary: This study investigated the molecular heterogeneity and clinical relevance of circulating tumor-initiating cells (CTICs) in hepatocellular carcinoma (HCC) using a novel integrated immunomagnetic-microfluidic platform. The platform detected significantly more CTICs in blood samples from HCC patients compared to the FDA-approved CellSearch system. The expression of stem-related markers on CTICs could distinguish primary HCC, recurrent HCC, and TACE-resistant HCC. Single-cell transcriptional profiling revealed the heterogeneity among individual CTICs and separated them into distinct phenotypes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Kazuto Takahashi, Kazuya Ofuji, Katsushi Hiramatsu, Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Katsuya Endo, Masayuki Higuchi, Masahiro Ohtani, Tomoyuki Nemoto, Yasunari Nakamoto
Summary: The study established a new method for isolating CTCs from HCC patients' blood samples with high sensitivity using a microcavity array system. The positivity rate of CTCs significantly impacted the survival rate of localized HCC patients.
Article
Nanoscience & Nanotechnology
Wen-Jing Zheng, Peng-Xiang Wang, Yun-Fan Sun, Jian-Wen Cheng, Yu-Chen Zhong, Yang Xu, Wei Guo, Bo Hu, Jian Zhou, Jia Fan, Xiang Chen, Xin-Rong Yang
Summary: This study investigated the molecular heterogeneity and clinical relevance of circulating tumor-initiating cells (CTICs) in hepatocellular carcinoma (HCC). Using a novel integrated immunomagnetic-microfluidic platform, the researchers were able to detect and characterize CTICs more accurately than the current FDA-approved system. The study also revealed the potential of CTICs' stem-related markers as predictors for disease recurrence and distinguishing different types of HCC.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang, Jun Xu
Summary: The dysregulation of KLF7 is involved in the development of various cancers, but its association with hepatocellular carcinoma (HCC) remains unclear. This study found that the KLF7/VPS35 axis promotes HCC cell progression by activating the Ccdc85c-mediated beta-catenin pathway, suggesting that targeting this signal axis could be a potential treatment strategy for HCC.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yao Zhang, Tingwang Shi, Yaohua He
Summary: The expression of GPR35 in bone marrow mesenchymal stem cells is suppressed in osteoporosis patients and mice, affecting osteogenic differentiation. GPR35 deficiency impairs the function of BMSCs, while overexpression contributes to osteogenesis. The synthetic GPR35 agonist zaprinast can reduce bone loss and promote bone generation, suggesting a potential novel treatment for osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Jian Song, Tingting Ren, Yanheng Duan, Haitao Guo, Gang Wang, Yu Gan, Mengcai Bai, Xiaotian Dong, Zheng Zhao, Jiaze An
Summary: Near-infrared fluorescence (NIRF) imaging has promising potential for noninvasive cancer imaging. However, the lack of tumor sensitivity and specificity hinders the application of NIRF dyes in surgical navigation. This study demonstrates that the NIRF dye MHI-148 exhibits higher imaging intensity and preferential uptake and retention in hepatocellular carcinoma (HCC) cells and tissues, which is mediated by the membrane transporters OATP2B1 and ABCG2 regulated by the b-catenin signaling pathway.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Minghao Xu, Chenhao Zhou, Jialei Weng, Zhaoshuo Chen, Qiang Zhou, Jian Gao, Guoming Shi, Aiwu Ke, Ning Ren, Huichuan Sun, Yinghao Shen
Summary: This study found that tumor-associated macrophages enhance aerobic glycolysis and proliferation in hepatocellular carcinoma cells by transmitting a long non-coding RNA called lncMMPA through exosomes. Furthermore, lncMMPA increases the proliferation of HCC cells by interacting with miR-548s. Clinically, lncMMPA expression is associated with glycolysis in TAMs and reduced survival of HCC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Taro Yamashita, Naohiko Koshikawa, Tetsuro Shimakami, Takeshi Terashima, Masatoshi Nakagawa, Kouki Nio, Rika Horii, Noriho Iida, Kazunori Kawaguchi, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Azusa Kitao, Satoshi Kobayashi, Shizuko Takahara, Yasuhito Imai, Kenichi Yoshimura, Toshinori Murayama, Yasunari Nakamoto, Eisaku Yoshida, Toru Yoshimura, Motoharu Seiki, Shuichi Kaneko
Summary: The study found that the LG2m gene signature is associated with poor prognosis in hepatocellular carcinoma (HCC) patients, and elevated serum LG2m may be a risk factor for HCC development. In chronic hepatitis C (CHC) patients who have achieved sustained virological response (SVR), elevated serum LG2m is correlated with a high incidence of HCC.
Article
Medicine, General & Internal
Xiaoyun Hu, Guosheng Yuan, Qi Li, Jing Huang, Xiao Cheng, Jinzhang Chen
Summary: High expression of DHX32 is associated with reduced overall survival in HCC patients. DHX32 upregulation induces EMT, promotes mobility and proliferation of HCC cells, and enhances tumor growth in vivo. Silencing DHX32 reverses EMT, inhibits malignancy behaviors of HCC cells, and suppresses tumor growth.
ANNALS OF MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Qingxian Wang, Yumei Tang, Yuansen Ge, Songming Zhang, Meiyuan Zheng
Summary: This study found that the long non-coding RNA NRAV plays a role in enhancing the viability, proliferation, and invasion of hepatocellular carcinoma (HCC) cells. Patients with high NRAV expression had a poor prognosis. Furthermore, NRAV may trigger the Wnt/beta-catenin signaling pathway by modulating the miR-199a-3p/CISD2 axis.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Immunology
Cheng Zhou, Bao-Ye Sun, Pei-yun Zhou, Zhang-Fu Yang, Zhu-Tao Wang, Gao Liu, Wei Gan, Zheng Wang, Jian Zhou, Jia Fan, Yong Yi, Ning Ren, Shuang-Jian Qiu
Summary: The combination of antiangiogenic agents and immune checkpoint inhibitors is more effective than monotherapy in treating hepatocellular carcinoma (HCC). The study found that treatment with lenvatinib and anti-PD1 antibody increased the TNF-NFKB pathway in all immune cell types. Additionally, TNF secreted by mucosal-associated invariant T (MAIT) cells activated TNFRSF1B on regulatory T cells, promoting immunosuppression.
CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jingyi Xie, Haijiao Wang, Wuxing Xie, Yongping Liu, Yi Chen
Summary: This study identified gallic acid (GA) as a critical inducer of ferroptosis in hepatocellular carcinoma (HCC), inhibiting the Wnt/β-catenin pathway. GA shows promise as a potential candidate for the clinical treatment of HCC.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chia-Lin Chen, Juan Carlos Hernandez, Dinesh Babu Uthaya Kumar, Tatsuya Machida, Stanley M. Tahara, Anthony El-Khoueiry, Meng Li, Vasu Punj, Suresh Kumar Swaminathan, Ameya Kirtane, Yibu Chen, Jayanth Panyam, Keigo Machida
Summary: The improvement of drug selectivity, toxicity, and reduced recurrence of tumors from tumor-initiating stem-like cells is essential for effective cancer therapy. Through high-throughput screens, a combination of histone deacetylase (HDAC) inhibitor(s) and all-trans retinoic acid (ATRA) has been found to effectively inhibit TIC growth. This combined treatment reduces Toll-like receptors (TLR) and stemness genes, leading to loss of self-renewal property of TICs.
Article
Plant Sciences
Qing Tang, Sheng Yang, Jie Tong, Xu Li, Junjie Wu, Senhong Wang, Jifen Zhang, Yi Chen, Xiaoyu Xu
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Engineering, Biomedical
Zhuo-heng Li, Yuan-yuan Li, Min Hou, Tao Yang, Lai-chun Lu, Xiao-Yu Xu
LASERS IN MEDICAL SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Li Li, Yi Yang, Mingxia Wu, Zanyang Yu, Chengqiang Wang, Guojun Dou, Hui He, Hongmei Wang, Na Yang, Hongyi Qi, Xiaoyu Xu
Article
Biochemistry & Molecular Biology
Li Li, Mingxia Wu, Chengqiang Wang, Zanyang Yu, Hongmei Wang, Hongyi Qi, Xiaoyu Xu
Article
Clinical Neurology
Yang Liu, He Ran, Yaping Xiao, Hongjin Wang, Yi Chen, Weihai Chen, Xiaoyu Xu
Article
Biochemistry & Molecular Biology
Xiuying Li, Fengchang Huang, Xiaoyu Xu, Shuenqin Hu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Yi Chen, Jiahui Wei, Ying Zhang, Wenwei Sun, Zhuoheng Li, Qin Wang, Xiaoyu Xu, Cong Li, Panhong Li
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Agriculture, Multidisciplinary
Guangning Kou, Zhenqing Li, Chao Wu, Yang Liu, Yan Hu, Liya Guo, Xiaoyu Xu, Zhiqin Zhou
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Shan Feng, Bingxun Qiu, Li Zou, Ke Liu, Xiaoyu Xu, Huifeng Zhu
DRUG DESIGN DEVELOPMENT AND THERAPY
(2018)
Article
Food Science & Technology
Guangning Kou, Junjie Wu, Meng Liu, Li Lin, Xiaoyu Xu, Zhiqin Zhou
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Plant Sciences
Qing Tang, Hui Ke, Chao Wu, Jie Zeng, Zhuohen Li, Yang Liu, Shan Feng, Qiang Xue, Xiaoyu Xu
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Plant Sciences
Zhuo-heng Li, Chao Wu, Hui Ke, Qiang Xue, Qing Tang, Jingjing Li, Shan Feng, Xiao-Yu Xu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Clinical Neurology
Hongjin Wang, Huan Yang, Yuhong Shi, Yaping Xiao, Yue Yin, Baoxiang Jiang, Huijing Ren, Weihai Chen, Qiang Xue, Xiaoyu Xu
Summary: Neurovascular dysfunction plays a crucial role in the pathogenesis of various cerebrovascular and neurodegenerative disorders. A novel 3D NVU model has been developed using primary neural stem cells and brain microvascular endothelial cells, showing promise for studying cerebral ischemia and potential therapeutic interventions.
Article
Chemistry, Multidisciplinary
Hong-jin Wang, Hai-feng Ran, Yue Yin, Xiao-gang Xu, Bao-xiang Jiang, Shi-qi Yu, Yi-jin Chen, Hui-jing Ren, Shan Feng, Ji-fen Zhang, Yi Chen, Qiang Xue, Xiao-yu Xu
Summary: In this study, it was found that catalpol can protect the NVU in ischemic stroke by activating the PI3K/AKT signaling pathway and increasing VEGF production, which subsequently enhances angiogenesis and neurogenesis. This protective mechanism forms a feed-forward loop to safeguard the NVU from the effects of ischemic stroke.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Plant Sciences
Hongjin Wang, Xiaogang Xu, Yue Yin, Shiqi Yu, Huijing Ren, Qiang Xue, Xiaoyu Xu