Journal
MOLECULAR CARCINOGENESIS
Volume 51, Issue -, Pages E65-E73Publisher
WILEY
DOI: 10.1002/mc.21849
Keywords
microRNA; polymorphism; colorectal cancer
Categories
Funding
- National Research Foundation of Korea (NRF)
- Korean Government [2009-0075784]
- Priority Centers Program through the NRF
- Ministry of Education, Science and Technology [2009-0093821]
- National Research Foundation of Korea [2009-0075784, 2009-0093821] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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MicroRNAs (miRNAs) are small, 18- to 22-nucleotide non-coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the miR-196a2CC genotype compared with the TT/CT genotype (AOR?=?1.50; 95% CI?=?1.112.04; P?=?0.01; FDR-P?=?0.04). In the stratified analyses, we observed both weak and strong association data. We found stronger associations of the miR-196a2 variants in the non-diabetic and rectal cancer groups than other stratified groups. Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. (c) 2011 Wiley Periodicals, Inc.
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