Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Raffaella Maria Gadaleta, Antonio Moschetta
Summary: FGFR4 and its ligand FGF19 play crucial roles in cellular processes, including the development of liver tumors. FGFR4 inhibitors are a promising treatment option for HCC, while using FGF19 analogues to activate FGFR4-KLOTHO represents a novel therapeutic strategy for other liver diseases.
JOURNAL OF HEPATOLOGY
(2021)
Article
Chemistry, Medicinal
Xiaolu Chen, Yanan Liu, Liting Zhang, Daoxing Chen, Zhaojun Dong, Chengguang Zhao, Zhiguo Liu, Qinqin Xia, Jianzhang Wu, Yongheng Chen, Xiaohui Zheng, Yuepiao Cai
Summary: In this study, a series of indazole derivatives were designed and synthesized, with F-30 showing subtle selectivity for FGFR4 and affecting cell growth and migration in HCC cell lines by inhibiting FGFR4 pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Zhao-yan Liu, Yan Luo, Ai-ping Fang, Maierhaba Wusiman, Tong-tong He, Xiao-zhan Liu, Dinuerguli Yishake, Si Chen, Xiao-ting Lu, Yao-jun Zhang, Hui-lian Zhu
Summary: The study concluded that higher serum FGF21 levels were associated with worse survival in HCC patients, suggesting that serum FGF21 may be used as a novel metabolism-related prognostic biomarker for HCC.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Hiroyuki Suzuki, Hideki Iwamoto, Toshimitsu Tanaka, Takahiko Sakaue, Yasuko Imamura, Atsutaka Masuda, Toru Nakamura, Hironori Koga, Yujin Hoshida, Takumi Kawaguchi
Summary: This study demonstrates the impact of molecular-targeted agents (MTAs) on the tumor immune microenvironment (TIME) in the treatment of advanced hepatocellular carcinoma (HCC). The results show that cabozantinib activates the innate immune system, while lenvatinib and AZD4547 alter the TIME to a hot immune state by downregulating lipid metabolism-related genes. These findings support the use of combination immunotherapies for HCC treatment.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
Xiaomeng Zhang, Yazhou Wang, Jianfeng Ji, Dongjuan Si, Xueting Bao, Zhuangzhuang Yu, Yueyue Zhu, Liwen Zhao, Wei Li, Jian Liu
Summary: Fibroblast growth factor receptor 4 (FGFR4) has been identified as a potential target for hepatocellular carcinoma (HCC). A novel family of potent FGFR4 inhibitors, represented by compound A34, was designed and synthesized. A34 exhibited improved FGFR4 inhibitory capability and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines, indicating its potential as a novel anticancer agent for HCC.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Leilei Wang, Yuxiong Su, Wing Shan Choi
Summary: The study showed that melatonin suppresses invasion and migration of OSCC cells by blocking the FGF19/FGFR4 pathway, suggesting a potential alternative for OSCCs prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rosa M. M. Pascale, Diego F. F. Calvisi, Francesco Feo, Maria M. M. Simile
Summary: Liver lesions of F344 and BN rats, which represent a model for studying genetic predisposition to HCC and therapy response, cluster with human HCCB and HCCP, respectively. The proteolysis of DUSP1 and the activation of ERK, CKS1, and SKP2 play important roles in HCC progression. GNMT regulates SAM-methyl-transferase reactions and binds to gene promoters involved in HCC. MYBL2 upregulation promotes liver malignancy. Comparative genetics studies reveal clustering patterns of DNs and HCCs in rats and humans.
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Dentistry, Oral Surgery & Medicine
Zi-yue Gu, Rong Zhou, Duo Hong, Yong Han, Li-zhen Wang, Jiang Li, Zhi-yuan Zhang, Chao-ji Shi
Summary: This study reveals that the high expression of FGFR1 and FGFR4 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma.
Article
Oncology
Yaser Gamallat, Mitra Afsharpad, Soufiane El Hallani, Christopher A. Maher, Nimira Alimohamed, Eric Hyndman, Tarek A. Bismar
Summary: The large, nested variant of urothelial carcinoma is a specific subtype that requires attention due to its bland histology and potential for being missed in routine biopsies. This study identifies FGFR-3 as the most common mutation in this variant, along with other potential mutations that could be targeted with novel therapies. Additional molecular screening could identify therapeutic targets to improve the clinical outcome for these patients.
Review
Oncology
Wei Meng, Tao Chen
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive and lethal malignancy with a rising incidence, requiring novel treatment strategies.
Article
Medicine, General & Internal
Hyunjin Kim, Sujin Park, So Young Kang, Soomin Ahn, Kyoung-Mee Kim
Summary: The study found that FGFR2 amplification is associated with peritoneal seeding in gastric carcinoma patients and is significantly correlated with high TMB and female patients. Patients with FGFR2 amplification may be potential candidates for targeted therapy.
Review
Oncology
Milind Javle, Gentry King, Kristen Spencer, Mitesh J. Borad
Summary: This review summarizes the preclinical and clinical development of futibatinib, an irreversible FGFR1-4 inhibitor, which has shown promising activity against advanced, refractory cancers with FGFR aberrations. Future directions include exploring mechanisms of resistance and combination therapy approaches.
Article
Genetics & Heredity
Chunyu Liu, Ying Shen, Shuyan Tang, Jiaxiong Wang, Yiling Zhou, Shixiong Tian, Huan Wu, Jiangshan Cong, Xiaojin He, Li Jin, Yunxia Cao, Yihong Yang, Feng Zhang
Summary: In this study, we investigated a group of Han Chinese men with asthenoteratozoospermia, a common type of male infertility. Through whole-exome sequencing, we identified AKAP3 as a novel gene associated with multiple morphological abnormalities of the sperm flagella (MMAF). Two different deleterious variants of AKAP3 were found in unrelated MMAF-affected men, and subsequent experiments confirmed the impact of these variants on AKAP3 expression in spermatozoa. Interestingly, the clinical outcomes after intracytoplasmic sperm injection (ICSI) were different between these two cases, suggesting that AKAP3 dosage may influence the prognosis of ICSI treatment.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Rheumatology
Fangyi Wu, Xuling Han, Jing Liu, Zhenghua Zhang, Kexiang Yan, Beilan Wang, Lin Yang, Hejian Zou, Chengde Yang, Wei Huang, Li Jin, Jiucun Wang, Feng Qian, Zhenmin Niu
Summary: This study explores the association between variants in non MHC proteasome gene and AS, and finds that the rs12717 SNP in PSMB1 gene is significantly associated with AS. The study also discovers that PSMB1 regulates the RANK/RANKL signaling pathway and affects bone formation by inhibiting osteoclast differentiation.
Letter
Biochemistry & Molecular Biology
Shixiong Tian, Ziqi Wang, Liting Liu, Yiling Zhou, Yue Lv, Dongdong Tang, Jiaxiong Wang, Jing Jiang, Huan Wu, Shuyan Tang, Guanxiong Wang, Hao Geng, Fangbiao Tao, Hongbin Liu, Xiaojin He, Feng Zhang, Jinsong Li, Li Jin, Tao Huang, Chunyu Liu, Yunxia Cao
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Dermatology
Qianqian Peng, Yu Liu, Anke Huels, Canfeng Zhang, Yao Yu, Wenqing Qiu, Xiyang Cai, Yuepu Zhao, Tamara Schikowski, Katja Merches, Yun Liu, Yajun Yang, Jiucun Wang, Yong Zhao, Li Jin, Liang Zhang, Jean Krutmann, Sijia Wang
Summary: Solar lentigines (SLs) are a common sign of aging skin caused by chronic exposure to sunlight and environmental stressors. Recent studies have suggested a possible genetic component, but the findings are inconsistent. Through a multi-trait analysis, researchers discovered that genetic variants in the telomerase reverse transcriptase gene are significantly associated with non-facial SLs in East Asian and Caucasian populations. These variants are also related to facial SLs but not other skin aging or pigmentation traits, highlighting a previously unrecognized role of telomerase reverse transcriptase in lentigines formation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Genetics & Heredity
Shixiong Tian, Chaofeng Tu, Xiaojin He, Lanlan Meng, Jiaxiong Wang, Shuyan Tang, Yang Gao, Chunyu Liu, Huan Wu, Yiling Zhou, Mingrong Lv, Ge Lin, Li Jin, Yunxia Cao, Dongdong Tang, Feng Zhang, Yue-Qiu Tan
Summary: This study identified biallelic deleterious mutations of CFAP54 in three unrelated men with severe MMAF or NOA. These mutations were associated with abnormal sperm morphology, reduced sperm concentration and motility. Immunofluorescence assays showed reduced staining of four flagellar assembly-associated proteins in the spermatozoa of CFAP54-deficient men.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Plant Sciences
Xiao-Min Yang, Hai-Liang Meng, Jian-Lin Zhang, Yao Yu, Edward Allen, Zi-Yang Xia, Kong-Yang Zhu, Pan-Xin Du, Xiao-Ying Ren, Jian-Xue Xiong, Xiao-Yu Lu, Yi Ding, Sheng Han, Wei-Peng Liu, Li Jin, Chuan-Chao Wang, Shao-Qing Wen
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Hanni Ke, Shuyan Tang, Ting Guo, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu, Jiucun Wang, Feng Zhang, Yingying Qin, Li Jin, Zi-Jiang Chen
Summary: Whole-exome sequencing in a cohort of 1,030 patients with POI identified new likely pathogenic variants and revealed different genetic architectures between primary and secondary amenorrhea. This study expands our understanding of the genetic landscape underlying POI and provides insights that have the potential to improve diagnostic genetic screenings.
Article
Oncology
Huangbo Yuan, Tao Qing, Sibo Zhu, Xiaorong Yang, Weicheng Wu, Kelin Xu, Hui Chen, Yanfeng Jiang, Chengkai Zhu, Ziyu Yuan, Tiejun Zhang, Li Jin, Chen Suo, Ming Lu, Xingdong Chen, Weimin Ye
Summary: Defects in DNA damage repair pathways can lead to genomic instability and oncogenesis. DDR alterations in esophageal squamous cell carcinoma (ESCC) affect mutational processes and tumor immune microenvironment.
Article
Environmental Sciences
Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Ziyu Yuan, Qiyun Wu, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye
Summary: This study investigated the association between 12 trace elements and gastroesophageal cancers (GOC) using hair and fingernail samples collected from GOC cases and controls in Taixing, China. The results showed that higher levels of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with increased GOC, while higher levels of Mg, Mn, Sr, and As were inversely associated with GOC. Interaction effects between hair level of Cr and smoking or alcohol drinking were also observed.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yang Gao, Xiaofei Yang, Hao Chen, Xinjiang Tan, Zhaoqing Yang, Lian Deng, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Hao Sun, Xiaohan Zhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Binyin Shi, Li Jin, Zhibin Hu, Yan Lu, Jiayou Chu, Kai Ye, Shuhua Xu
Summary: The data from the Chinese Pangenome Consortium's first phase reveals a substantial increase in the discovery of novel and missing sequences when individuals from underrepresented minority ethnic groups are included. The missing reference sequences contain archaic-derived alleles and genes related to keratinization, response to ultraviolet radiation, DNA repair, immunological responses, and lifespan, suggesting great potential for understanding human evolution and filling in missing heritability in complex diseases.
Article
Neurosciences
Jincheng Li, Sibo Zhu, Yingzhe Wang, Min Fan, Jiacheng Dai, Chengkai Zhu, Kelin Xu, Mei Cui, Chen Suo, Li Jin, Yanfeng Jiang, Xingdong Chen
Summary: By comparing the gut microbiota in a community-based cohort, it was found that bacteria capable of producing SCFAs were positively associated with better cognitive performance. In addition, specific bacterial strains were more abundant in individuals with MCI or CN groups and were correlated with cognitive performance.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Applied
Junyu Luo, Qili Qian, Wenxin Zheng, Ieva Gripkauskaite, Sijie Wu, Min Zhang, Jinxi Li, Bingfei Fu, Ranjit Bhogal, Peter Murray, Matthew Rowson, Bin Li, Xiangyang Xue, Xuelan Gu, Yajun Yang, Li Jin, David Andrew Gunn, Sijia Wang
Summary: This study investigated the extent to which scalp hair parameters change with age in Chinese men and women. The number of hairs per follicular unit was found to have a negative correlation with age in both men and women. Men had a greater number of hairs and follicular units than women on average, but experienced a greater decrease in the number of hairs per follicular unit with age, particularly in multi-hair follicular units. Hair loss was not random across follicular units, and a higher number of hairs per follicular unit increased the risk of hair loss. The results suggest that the presence of multi-hair follicular units on the scalp contributes to the greater susceptibility of scalp hair to hair loss compared to other body sites.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Editorial Material
Multidisciplinary Sciences
Yi Li, Meng Hao, Zixin Hu, Yanyun Ma, Kun Wang, Xiaoyu Liu, Xianhong Yin, Menghan Zhang, Yi Wang, Meng Liang, Yuan Guo, Lei Bao, Shixuan Zhang, Shiguan Le, Chenyuan Wu, Dayan Sun, Yang Wei, Fei Wu, Rui Zhang, Lingxian Zhu, Hui Zhang, Shuai Jiang, Xingdong Chen, Xiaofeng Wang, Yao Zhang, Longli Kang, Wenyuan Duan, Bin Qiao, Jiucun Wang, Li Jin
NATIONAL SCIENCE REVIEW
(2023)
Article
Medicine, Research & Experimental
Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, Qun Li, Lan Yu, Lin Li, Yao Xu, Ling Wu, Xiaoyan Mao, Jing Fu, Bin Li, Zheng Yan, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Lin Zhao, Weijie Wang, Zhou Zhou, Jie Dong, Qiaoli Li, Li Jin, Lin He, Xiaoxi Sun, Ge Lin, Yanping Kuang, Lei Wang, Qing Sang
Summary: By analyzing whole-exome sequencing data of 606 women with PREMBA, researchers have identified a candidate gene KPNA7, which may contribute to the development of PREMBA. The study further revealed that KPNA7 mutations reduce protein levels, impair its binding capacity to substrate RSL1D1, and affect nuclear transport activity. Furthermore, the study found that mouse KPNA2 plays a critical role in embryonic development and its deficiency leads to embryo arrest, similar to human PREMBA cases. These findings provide a mechanistic understanding of PREMBA and a diagnostic marker for PREMBA patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Genetics & Heredity
Jialin Li, Qingxia Huang, Yingzhe Wang, Mei Cui, Kelin Xu, Chen Suo, Zhenqiu Liu, Yanpeng An, Li Jin, Huiru Tang, Xingdong Chen, Yanfeng Jiang
Summary: Cardiovascular health is linked to a lower risk of cognitive decline, and this association may be mediated by metabolic perturbations. The study found that better cardiovascular health was associated with a lower risk of concentration and orientation decline. Certain blood components, such as apolipoprotein-A1 and high-density lipoprotein cholesterol, were also associated with a lower risk of memory and orientation decline. Mediation analysis suggested that cholesterol ester and total lipids in medium-size HDL may partially mediate the negative association between health status and the risk of orientation decline. These findings highlight the potential of using lipoproteins as targets for early stage dementia screening and intervention.
