Article
Multidisciplinary Sciences
Kevin Guedj, Mathieu Uzzan, Damien Soudan, Catherine Trichet, Antonino Nicoletti, Emmanuel Weiss, Hana Manceau, Alexandre Nuzzo, Olivier Corcos, Xavier Treton, Katell Peoc'h
Summary: In this study, low levels of intestinal fatty acid-binding protein (I-FABP) were observed in COVID-19 patients, regardless of the presence of gastrointestinal symptoms, compared to patients with non-COVID-19 pulmonary diseases and abdominal pain. I-FABP levels were not associated with disease severity or symptom duration, but correlated with polymorphonuclear cell counts. Further research on a larger patient cohort is needed to investigate the molecular mechanisms and clinical implications of these findings, including the effects of malabsorption and abnormal lipid metabolism.
Article
Chemistry, Medicinal
Andre Fischer, Gabriela Frehner, Markus A. Lill, Martin Smiesko
Summary: Thyroid hormone receptors (TRs) are crucial for human development, growth, and metabolism, and antagonists of TRs can effectively treat hyperthyroidism. Computational methods such as MD simulations provide valuable insights into ligand-induced conformational changes in nuclear receptors, which can be important for the development of novel therapeutics.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Review
Cell Biology
Jing Xu, Yan Huang, Jimeng Zhao, Luyi Wu, Qin Qi, Yanan Liu, Guona Li, Jing Li, Huirong Liu, Huangan Wu
Summary: Cofilin is a protein that plays a crucial role in cancer metastasis by regulating cytoskeletal reorganization and other processes. Clinical studies have explored the relationship between cofilin, tumor cells apoptosis, and cofilin-related miRNAs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Erin A. Catton, Daniel A. Bonsor, Carolina Herrera, Margaretha Stalhammar-Carlemalm, Mykola Lyndin, Claire E. Turner, Jo Soden, Jos A. G. van Strijp, Bernhard B. Singer, Nina M. van Sorge, Gunnar Lindahl, Alex J. McCarthy
Summary: Infection with Streptococcus pyogenes after childbirth can have life-threatening consequences. Here, Catton et al. show that the epidemiologically associated bacterial R28 protein targets the human CEACAM1 receptor to facilitate the pathogenesis of bacterial sepsis.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Matthew L. Kraushar, Ferdinand Krupp, Dermot Harnett, Paul Turko, Mateusz C. Ambrozkiewicz, Thiemo Sprink, Koshi Imami, Manuel Guennigmann, Ulrike Zinnall, Carlos H. Vieira-Vieira, Theres Schaub, Agnieszka Muenster-Wandowski, Joerg Buerger, Ekaterina Borisova, Hiroshi Yamamoto, Mladen-Roko Rasin, Uwe Ohler, Dieter Beule, Thorsten Mielke, Victor Tarabykin, Markus Landthaler, Guenter Kramer, Imre Vida, Matthias Selbach, Christian M. T. Spahn
Summary: This study explores the architecture of ribosomes in the developing nervous system and identifies Ebp1 as a crucial factor in protein synthesis, playing a key role in cell morphology and the synthesis of membrane-targeted cell adhesion molecules. Ebp1 regulates ribosome occupancy of specific codons during different stages of protein synthesis in the neocortex, highlighting its importance in neuronal development.
Editorial Material
Biochemistry & Molecular Biology
Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael Bloomfield, Michael Browning, Anthony J. Cleare, Phillip Corlett, J. F. William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver D. Howes, Mario F. Juruena, Raymond W. Lam, Stephen M. Lawrie, Hamish McAllister-Williams, Steven Marwaha, David Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selvaraj, Paul Stokes, Rachel Upthegrove, Nefize Yalin, Lakshmi Yatham, Allan H. Young, Roland Zahn, Philip J. Cowen
Summary: A recent umbrella review found no consistent evidence linking serotonin to the pathophysiology of depression. However, we argue that this conclusion is overstated due to methodological weaknesses, selective reporting of data, oversimplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two most relevant research areas, to support our argument.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Sarah E. Alexander, Gavin Abbott, Brad Aisbett, Glenn D. Wadley, Jill A. Hnatiuk, Severine Lamon
Summary: In pre-menopausal females, total testosterone was not significantly associated with lean mass index (LMI) or handgrip strength, while free androgen index (FAI) showed a quadratic association with LMI. Handgrip strength was not associated with FAI or total testosterone in pre-menopausal females without pharmacological alterations in testosterone concentrations.
SCIENTIFIC REPORTS
(2021)
Article
Anatomy & Morphology
S. Petryszyn, L. Saidi, D. Gagnon, A. Parent, M. Parent
Summary: The study investigated the changes in morphology and distribution of striatal interneurons expressing calretinin in a mouse model of Parkinson's disease. It found that medium-sized calretinin-positive interneurons are specifically targeted by dopamine denervation, while small and intensely immunoreactive calretinin-positive cells remain unaffected. These results suggest that the expression of calretinin may play a protective role against altered corticostriatal transmission in Parkinson's disease.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Ryan J. Boyd, Tien L. Olson, James D. Zook, Derek Stein, Manuel Aceves, Wan-Hsin Lin, Felicia M. Craciunescu, Debra T. Hansen, Panos Z. Anastasiadis, Abhishek Singharoy, Petra Fromme
Summary: This study investigated the protein expression and purification of human Syx and revealed its folded state and binding ability to RhoA. Additionally, computational simulations were used to explore the interactions between GEF activity and the PH domain, providing insights into the allosteric modulation of Dbl homology GEF proteins.
Article
Biology
Marcin Roganowicz, Dominik Bar, Cristiana Bersaglieri, Rossana Aprigliano, Raffaella Santoro
Summary: BAZ2A represses not only rRNA genes but also genes frequently silenced in metastatic prostate cancer through its RNA-binding TAM domain, which interacts with TOP2A and KDM1A. RNA-based interactions between BAZ2A and TOP2A/KDM1A play a critical role in gene regulation in prostate cancer and may have implications for risk stratification and treatment.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Byeong-Seong Kim, Hyo Rim Ko, Inwoo Hwang, Sung-Woo Cho, Jee-Yin Ahn
Summary: EibB3-binding protein 1 (EBP1) suppresses histone methyltransferase activity of Suv39H1 by promoting its degradation through the ubiquitin-proteasome system (UPS), leading to proper heterochromatin assembly during neural development.
Article
Infectious Diseases
Julia M. Wortman, Emiel Leegwater, Danielle Van Lammeren-Venema, Cees Van Nieuwkoop, Annemieke Sobels, Erik B. Wilms
Summary: This study found a potential interaction between flucloxacillin and posaconazole, resulting in decreased posaconazole serum concentrations. Careful monitoring of posaconazole levels is recommended when concomitant use of flucloxacillin cannot be avoided.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Nutrition & Dietetics
Hanyuan Xu, Xiaorui Lyu, Xiaonan Guo, Hongbo Yang, Lian Duan, Huijuan Zhu, Hui Pan, Fengying Gong, Linjie Wang
Summary: The main component in lotus leaf called Nuciferine (Nuci) has been found to prevent obesity induced by high fat diet. It reduces lipid accumulation in liver/hepatocytes and adipocytes/eWAT by regulating AMPK-mediated FAS/HSL pathway. Nuci supplementation also improves glycolipid metabolism, enhances energy expenditure and attenuates hepatic steatosis.
Article
Biochemistry & Molecular Biology
Tanyeri Barak, Emma Ristori, A. Gulhan Ercan-Sencicek, Danielle F. Miyagishima, Carol Nelson-Williams, Weilai Dong, Sheng Chih Jin, Andrew Prendergast, William Armero, Octavian Henegariu, E. Zeynep Erson-Omay, Akdes Serin Harmanal, Mikhael Guy, Batur Gultekin, Deniz Kilic, Devendra K. Rai, Nukte Goc, Stephanie Marie Aguilera, Burcu Gulez, Selin Altinok, Kent Ozcan, Yanki Yarman, Suleyman Coskun, Emily Sempou, Engin Deniz, Jared Hintzen, Andrew Cox, Elena Fomchenko, Su Woong Jung, Ali Kemal Ozturk, Angeliki Louvi, Kaya Bilguvar, E. Sander Connolly, Mustafa K. Khokha, Kristopher T. Kahle, Katsuhito Yasuno, Richard P. Lifton, Ketu Mishra-Gorur, Stefania Nicoli, Murat Gunel
Summary: Genomic analyses in individuals with index and familial intracranial aneurysms revealed pathogenic variants in the PPIL4 gene, which regulates cerebral angiogenesis and cerebrovascular integrity through the Wnt signaling pathway. Mutations in the PPIL4 gene were found to be associated with the pathogenesis of IA by impacting brain-specific angiogenesis and maintenance of cerebrovascular integrity.
Article
Medicine, Research & Experimental
Cui-ping Guo, Wen-sheng Li, Yi Liu, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Jian-zhi Wang, Rong Liu, Hong-lian Li, Xiao-chuan Wang, Xiang Gao
Summary: This study found that the phosphorylation level of CREB decreased in the hippocampus of rats with MK801-induced schizophrenia. The inhibition of ERK1/2 further reduced the phosphorylation of CREB and induced synaptic dysfunction and cognitive impairment. Therefore, activating the ERK1/2-CREB pathway may be therapeutic for treating cognitive deficits in schizophrenia.
CURRENT MEDICAL SCIENCE
(2023)
Article
Urology & Nephrology
Tuyet Hong T. Tran, Jonathan Melamed, Fang-Ming Deng
Summary: Gastric cancer is a rare long-term complication following gastrocystoplasty, predominantly in males who present with hematuria and develop cancer at a younger age, more than 10 years post-surgery. While annual surveillance for malignancy may not be effective due to its rarity, symptomatic patients, particularly those 10 years after the surgery, require detailed evaluation.
Letter
Medical Laboratory Technology
Abdallah Flaifel, Melissa Guzzetta, Michael Occidental, Bobby B. Najari, Jonathan Melamed, Kristen M. Thomas, Fang-Ming Deng
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Brittany A. Borden, Yasmine Baca, Joanne Xiu, Fabio Tavora, Ira Winer, Benjamin A. Weinberg, Ari M. Vanderwalde, Sourat Darabi, W. Michael Korn, Andrew P. Mazar, Francis J. Giles, Lorin Crawford, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Summary: The study analyzed GSK-3β alterations in tumors, finding that most mutations occurred in the kinase domain, with uterine endometrioid carcinoma having the highest mutation rate. Moreover, tumors with GSK-3β mutations displayed a microenvironment with increased B cell infiltration and were associated with increased PD-L1 expression in certain tissues.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pathology
Hemlata Shirsat, Fang Zhou, Jason C. Chang, Natasha Rekhtman, Anjali Saqi, Kimon Argyropoulos, Lea Azour, Anthony Simms, Jonathan Melamed, Yin P. Hung, Anja C. Roden, Mari Mino-Kenudson, Andre L. Moreira, Navneet Narula
Summary: In a retrospective review of frozen sections from 18 cases of BAs/CMPTs, only 3 were correctly diagnosed during intraoperative consultation, with the majority being misdiagnosed as adenocarcinomas or other proliferative disorders. Recognition of the presence of a mixture of cell types, a basal cell layer, and the absence of necrosis, significant atypia, and mitoses may help prevent misdiagnosis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Pathology
Mahmut Akgul, Sean R. Williamson, Dilek Ertoy, Pedram Argani, Sounak Gupta, Anna Calio, Victor Reuter, Satish Tickoo, Hikmat A. Al-Ahmadie, George J. Netto, Ondrej Hes, Michelle S. Hirsch, Brett Delahunt, Rohit Mehra, Stephanie Skala, Adeboye O. Osunkoya, Lara Harik, Priya Rao, Ankur R. Sangoi, Maya Nourieh, Debra L. Zynger, Steven Cristopher Smith, Tipu Nazeer, Berrak Gumuskaya, Ibrahim Kulac, Francesca Khani, Maria S. Tretiakova, Funda Vakar-Lopez, Guliz Barkan, Vincent Molinie, Virginie Verkarre, Qiu Rao, Lorand Kis, Angel Panizo, Ted Farzaneh, Martin J. Magers, Joseph Sanfrancesco, Carmen Perrino, Dibson Gondim, Ronald Araneta, Jeffrey S. So, Jae Y. Ro, Matthew Wasco, Omar Hameed, Antonio Lopez-Beltran, Hemamali Samaratunga, Sara E. Wobker, Jonathan Melamed, Liang Cheng, Muhammad T. Idrees
Summary: TFE3-rearranged renal cell carcinoma (TFE3-RCC) presents with heterogenous morphologic and IHC features, with pathologists primarily focusing on cytologic characteristics and TFE3 IHC expression in the diagnostic work-up. Variability and preferences exist among participants in the use of additional IHC assays, positive cut-off for TFE3 FISH, and the need for further molecular studies in confirming TFE3-RCC diagnosis.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Letter
Medical Laboratory Technology
Abdallah Flaifel, Jonathan Melamed, Fang-Ming Deng
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Pathology
Fang-Ming Deng, Bogdan Isaila, Derek Jones, Qinghu Ren, Park Kyung, Deepthi Hoskoppal, Hongying Huang, Leili Mirsadraei, Yuhe Xia, Jonathan Melamed
Summary: The study found that global Grade Group (GG) shows better consistency with RP-targeted lesion GG compared to highest or largest GG in MRI-targeted biopsies, especially in cases where biopsy grades differ, suggesting the use of global GG for reporting MRI lesion-targeted biopsies.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Correction
Rheumatology
Benjamin Plotz, Rochelle Castillo, Jonathan Melamed, Gerard Nuovo, Cynthia Magro, Pamela Rosenthal, H. Michael Belmont
Article
Medical Laboratory Technology
Lucy Wang, Melissa Yee-Chang, Wei Sun, Jonathan Melamed, Aylin Simsir, Yan Shi
Summary: This case report presents a challenging cytologic diagnosis of soft tissue MEC, with subsequent core biopsy and immunohistochemical staining confirming the diagnosis.
DIAGNOSTIC CYTOPATHOLOGY
(2022)
Article
Pathology
Lei Zhang, Xiaoyan Liu, Rong Xia, Fei Chen, Xin Wang, Jia Bao, Yongzhao Shao, Xian Lu, Yan Wang, Jili Wang, May Thu Tun, Jonathan Melamed, Hebert Lepor, Fang-Ming Deng, Dongwen Wang, Guoping Ren
Summary: The clinicopathological features of PCa differ between the USA and Chinese populations, including patient age, preoperative PSA levels, Gleason scores, and Grade Groups. These differences may be influenced by treatment strategies.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Letter
Oncology
F. Tavora, J. C. de Sousa
Letter
Respiratory System
Iusta Caminha, Fabio Tavora, Juliana Sousa, Francisco Martins Neto, Luciano Pamplona de Goes Cavalcanti
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Medicine, Research & Experimental
Hans Pinckaers, Jolique van Ipenburg, Jonathan Melamed, Angelo De Marzo, Elizabeth A. Platz, Bram van Ginneken, Jeroen van der Laak, Geert Litjens
Summary: This study found that using deep learning to analyze tissue morphology in metastatic prostate cancer patients can predict biochemical recurrence. Through interpretability methods, tissue patterns can be explained in ways that pathologists can understand.
COMMUNICATIONS MEDICINE
(2022)
Meeting Abstract
Medicine, Research & Experimental
Derek Jones, Leili Mirsadraei, Kimon Argyropoulos, Jonathan Melamed, Fangming Deng, Kyung Park, Qinghu Ren
LABORATORY INVESTIGATION
(2021)
Meeting Abstract
Medicine, Research & Experimental
Leah Geiser Roberts, Jonathan Melamed
LABORATORY INVESTIGATION
(2021)