Review
Biochemistry & Molecular Biology
Menno ter Huurne, Hendrik G. Stunnenberg
Summary: During early embryonic development, the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated and interconnected processes. Transcription factors and signaling pathways play a crucial role in maintaining pluripotency and cell cycle progression, while canonical cell cycle regulators impact molecular networks controlling pluripotency and lineage specification.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Patrick Diaba-Nuhoho
Summary: This article reviews the role and potential mechanisms of PHF5A in tumorigenesis, and discusses its importance and prospects in the treatment of different cancer types.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Jan M. Suski, Nalin Ratnayeke, Marcin Braun, Tian Zhang, Vladislav Strmiska, Wojciech Michowski, Geylani Can, Antoine Simoneau, Konrad Snioch, Mikolaj Cup, Caitlin M. Sullivan, Xiaoji Wu, Joanna Nowacka, Timothy B. Branigan, Lindsey R. Pack, James A. DeCaprio, Yan Geng, Lee Zou, Steven P. Gygi, Johannes C. Walter, Tobias Meyer, Piotr Sicinski
Summary: CDC7 is dispensable for cell division, while CDK1 is active during G1/S transition and performs functionally redundant roles with CDC7.
Article
Hematology
Wenchao Wu, Geoffrey M. Nelson, Raphael Koch, Katherine A. Donovan, Radoslaw P. Nowak, Tayla B. Heavican-Foral, Ajit J. Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E. Stevenson, Marcus Kenneth Jones, Samuel Y. Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L. Donaldson, Patrick R. Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S. Fischer, Karen Adelman, David M. Weinstock
Summary: This study identifies two factors that determine resistance to immunomodulatory (IMiD) agents in T-cell lymphomas (TCLs). Limited CRBN expression reduces IMiD activity, but this can be overcome by a newer-generation degrader, CC-92480. Furthermore, the transcription factor ZFP91 plays a role in resistance to IMiDs, and targeting it shows promising results. These findings provide insights for developing novel therapies.
Article
Multidisciplinary Sciences
Pooya Naseri-Nosar, Maciej T. Nogalski, Thomas Shenk
Summary: Following human cytomegalovirus (HCMV) infection, the aryl hydrocarbon receptor (AhR) is activated and alters the levels of numerous RNAs, including those related to cell cycle progression. AhR knockdown alleviates the G1/S cell cycle block in HCMV-infected fibroblasts, providing mechanistic insight into the virus-host cell interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Xixi Zhou, Rachel M. Speer, Lindsay Volk, Laurie G. Hudson, Ke Jian Liu
Summary: Arsenic exposure at environmentally relevant levels can enhance the carcinogenic effect of other agents, such as UV radiation, by inhibiting DNA repair. This review highlights the recent advances in understanding the mechanisms of arsenic carcinogenesis, including DNA damage induction and ROS generation, particularly focusing on how arsenic inhibits DNA repair through interactions with sensitive zinc finger DNA repair proteins.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura A. Murray-Nerger, Joshua L. Justice, Pranav Rekapalli, Josiah E. Hutton, Ileana M. Cristea
Summary: Acetylation of lamin B1 at K134 is a molecular switch that controls nuclear periphery stability, cell cycle progression, and DNA repair. This modification prevents lamin disruption during HSV-1 infection, delays DNA damage resolution, and sustains activation of the G1/S checkpoint. Acetylation of LMNB1 negatively regulates canonical nonhomologous end joining and impacts DNA repair pathway choice.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jordan D. Pritts, Sarah L. J. Michel
Summary: Metal ions are commonly found as protein co-factors in biology. The distribution and utilization of metals in biology has evolved over time. Zinc finger proteins are a common class of metal co-factored proteins, but there have been cases where proteins annotated as zinc finger proteins actually contain Fe-S clusters. Researchers can differentiate the metal co-factors using bioinformatics and specific methods.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Oncology
Su-Yeon Lee, Sanghwa Kim, Yeonhwa Song, Namjeong Kim, Joohwan No, Kang Mo Kim, Haeng Ran Seo
Summary: Hepatocellular carcinoma (HCC) is a common malignant cancer with high mortality. This study identified sorbitol dehydrogenase (SORD) as a potential therapeutic target for HCC treatment. High SORD expression was associated with better overall survival in liver cancer patients. Further investigation revealed that SORD inhibits tumor growth and stemness by regulating lactate dehydrogenase A (LDHA) expression and mitochondrial dynamics. Targeting SORD expression may be a promising therapeutic strategy for liver cancer.
Article
Biochemistry & Molecular Biology
Diego Lastra, Maribel Escoll, Antonio Cuadrado
Summary: This study explores the involvement of transcription factor NRF2 in the cell division cycle and finds that NRF2 levels are highest during S phase entry and lowest during mitosis. NRF2 depletion leads to G1 and M arrest and affects key cell cycle regulators.
Review
Plant Sciences
Jibril Lubega, Saima Umbreen, Gary J. Loake
Summary: S-nitrosylation is a key regulatory post-translational modification controlling the plant immune response by regulating the activities of proteins such as GSNO and GSNOR1, thereby affecting processes like antioxidant defense and selective autophagy.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Mi Kyung Park, Ho Lee, Chang Hoon Lee
Summary: This review article provides an overview of the diverse functions of PTM in protein regulation and the pivotal role of ZEB family transcription factors in tumour progression and metastasis. The article also discusses the PTM of ZEBs and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sehbanul Islam, Parul Dutta, Kriti Chopra, Srikanth Rapole, Radha Chauhan, Manas Kumar Santra
Summary: The expression levels of F-box protein beta-TrCP1 oscillate during cell cycle progression and are regulated by another F-box protein FBXW8. FBXW8 directs the proteasomal degradation of beta-TrCP1 in a MAPK pathway-dependent manner, which is crucial for cell cycle transition and DNA damage-free progression of the cell cycle.
Article
Biochemistry & Molecular Biology
Chie-Hong Wang, Hsuan-Cheng Wu, Chen-Wei Hsu, Yun-Wei Chang, Chiung-Yuan Ko, Tsung- Hsu, Jian-Ying Chuang, Tsui-Hwa Tseng, Shao-Ming Wang
Summary: The expression of MZF1 is elevated in GBM and is associated with a worse prognosis. CTD exhibits strong anti-proliferative effects on GBM cells by suppressing MZF1 expression. This study suggests that CTD may be a promising therapeutic agent for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Dermatology
Ai Yoshioka, Susumu Fujiwara, Hiroki Kawano, Hajime Nakano, Shigeru Taketani, Toshimitsu Matsui, Yoshio Katayama, Chikako Nishigori
ACTA DERMATO-VENEREOLOGICA
(2018)
Article
Hematology
Hiroshi Higuchi, Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ryutaro Kotaki, Jun Ogata, Masatoshi Kakizaki, Koji Fujita, Jun Lu, Kazuaki Yokoyama, Kazuki Okuyama, Ai Sato, Masako Takamatsu, Natsumi Kurosaki, Syakira Mohamad Alba, Azran Azhim, Ryouichi Horie, Toshiki Watanabe, Toshio Kitamura, Kiyoshi Ando, Takao Kashiwagi, Toshimitsu Matsui, Akinao Okamoto, Hiroshi Handa, Masahiko Kuroda, Naoya Nakamura, Ai Kotani
Article
Oncology
Senn Wakahashi, Fumi Kawakami, Kanako Wakahashi, Kentaro Minagawa, Keitaro Matsuo, Yoshio Katayama, Hideto Yamada, Toshimitsu Matsui, Tamotsu Sudo
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Hematology
Yayoi Matsumura-Kimoto, Junya Kuroda, Hitomi Kaneko, Yuri Kamitsuji, Shin-ichi Fuchida, Aya Nakaya, Hirohiko Shibayama, Nobuhiko Uoshima, Isao Yokota, Hitoji Uchiyama, Hideo Yagi, Satoru Kosugi, Toshimitsu Matsui, Jun Ishikawa, Mitsuhiro Matsuda, Kensuke Ohta, Masato Iida, Hirokazu Tanaka, Masayuki Kobayashi, Katsuya Wada, Chihiro Shimazaki, Shosaku Nomura, Kazunori Imada, Masayuki Hino, Itaru Matsumura, Yuzuru Kanakura, Akifumi Takaori-Kondo
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2018)
Article
Hematology
Kanako Wakahashi, Kentaro Minagawa, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Akiko Sada, Noboru Asada, Mari Sato, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Yoshio Katayama
Article
Hematology
Aya Nakaya, Hirokazu Tanaka, Hideo Yagi, Kensuke Ohta, Hirohiko Shibayama, Takae Kohara, Junya Kanda, Maki Shindo, Yuji Shimura, Satoru Kosugi, Toru Kida, Hitomi Kaneko, Kazunori Imada, Takahiro Karasuno, Mitsuhiro Matsuda, Masato Iida, Yoko Adachi, Shin-ichi Fuchida, Nobuhiko Uoshima, Hitoji Uchiyama, Ryoichi Takahashi, Toshimitsu Matsui, Katsuya Wada, Miki Kiyota, Chihiro Shimazaki, Masayuki Hino, Junya Kuroda, Yuzuru Kanakura, Akifumi Takaori-Kondo, Shosaku Nomura, Itaru Matsumura
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2020)
Article
Hematology
Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Noboru Asada, Yuko Kawano, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Yukio Nakamura, Seiya Mizuno, Satoru Takahashi, Toshimitsu Matsui, Yoshio Katayama
Summary: FGF-23, produced by erythroblasts, plays a crucial role in G-CSF-induced hematopoietic progenitor cell mobilization by inhibiting chemoattraction, facilitating the release of HPCs from bone marrow into circulation.
Article
Hematology
Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama
Summary: PPAR delta signaling induced by dietary fatty acids negatively regulates mobilization of hematopoietic stem/progenitor cells, partially through Angptl4 production. Treatment with anti-Angptl4 antibody enhances mobilization and bone marrow vascular permeability in mice.
Letter
Hematology
Omer Jamy, Raquel Innis-Shelton, Susan Bal, Ravi Paluri, Donna Salzman, Antonio Di Stasi, Luciano Costa, Ruby Meredith, Lawrence Lamb, Kentaro Minagawa, Shin Mineishi, Ayman Saad
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Hematology
Neal Shah, Kevin Rakszawski, Myles Nickolich, Christopher Ehmann, Baldeep Wirk, Seema Naik, Witold Rybka, Hong Zheng, Joseph Mierski, Brooke Silar, Gina Mackey, Robert Greiner, Valerie Brown, David Claxton, Shin Mineishi, Kentaro Minagawa
Summary: This study evaluated the outcomes of AML relapse after alloSCT and found that H + CT could improve the 1-year overall survival rate of patients, especially for those with a post-alloSCT relapse duration of less than 6 months.
ANNALS OF HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, Toshifumi Takao, Noriki Iwai, Takashi Mino, Osamu Takeuchi, Yoshiro Maru, Sachie Hiratsuka
Summary: Research shows that naked nonvesicular extracellular mRNA can be uptaken by cells and function in the nucleus. A zinc finger protein is able to capture nex-RNA and transport it to the nucleus to enhance the cell's antimetastatic characteristics.
NATURE COMMUNICATIONS
(2021)