Article
Integrative & Complementary Medicine
Xiao Li, Wei Liu, Chong Geng, Tingting Li, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: This study demonstrated that Ginsenoside Rg3 could effectively inhibit colon cancer cell invasion and metastasis by suppressing the Notch-Hes1-EMT signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Katsutoshi Kuriyama, Yuzo Kodama, Masahiro Shiokawa, Yoshihiro Nishikawa, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Tomoaki Matsumori, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno
Summary: Notch/Hes1 signaling is essential for the postnatal maturation of exocrine tissue in pancreatic progenitor cells, partially through the formation of centroacinar cells.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pathology
Hakan Soylu, Mustafa Kirca, Sema Avci, Bulent Ozpolat, Ismail Ustunel
Summary: The study found that both abiraterone and docetaxel treatments affect the expression of Notch signaling pathway proteins in prostate cancer cells, especially causing a significant upregulation in Hes1 expression. Therefore, the co-application of Notch signaling inhibitors with docetaxel and abiraterone chemotherapy may prevent the worsening of patient prognosis.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Angelos Papaspyropoulos, Andriani Angelopoulou, Ioanna Mourkioti, Aikaterini Polyzou, Daniela Pankova, Konstantinos Toskas, Simone Lanfredini, Anastasia A. Pantazaki, Nefeli Lagopati, Athanassios Kotsinas, Konstantinos Evangelou, Efstathios Chronopoulos, Eric O'Neill, Vassilis Gorgoulis
Summary: The interaction between RASSF1A and HES1 affects tumor differentiation and response to drug treatment, which is crucial for clinical therapy.
Article
Cell Biology
Shubham Dwivedi, Maricris Bautista, Sanskriti Shrestha, Hussain Elhasasna, Tanaya Chaphekar, Frederick S. Vizeacoumar, Anand Krishnan
Summary: Peripheral nerves may promote the progression of neuroendocrine prostate cancer, and high concentrations of the sympathetic neurotransmitter norepinephrine can induce neuroendocrine differentiation in prostate cancer cells, which can be effectively inhibited by medication.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Wei Wang, Ruiying Sun, Lizhong Zeng, Yang Chen, Na Zhang, Shiguang Cao, Shanshan Deng, Xia Meng, Shuanying Yang
Summary: The study revealed that GALNT2 is highly expressed in LUAD and is associated with poor prognosis. GALNT2 promotes cancer cell proliferation and migration by activating the Notch/Hes1-PTEN-PI3K/Akt signaling axis, suggesting a potential new therapeutic target for LUAD.
Article
Oncology
Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R. Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Haojie Huang
Summary: The study identifies a previously unrecognized tumor suppressive role of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Additionally, the findings suggest that aberrant elevation of AR protein could serve as a prognostic biomarker and therapeutic target for MAP3K7-deficient prostate cancer.
Review
Cell Biology
Frederick Allen, Ivan Maillard
Summary: The Notch signaling pathway has been investigated as a therapeutic target for cancers and immune/inflammatory disorders, orchestrating cell fate decisions and regulating immune responses through cell-to-cell contacts. It has shown potential in inhibiting tumor growth and preventing/reversing inflammatory disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ahmed Alafnan, Nasrin E. E. Khalifa, Talib Hussain, Mhdia Elhadi Osman
Summary: This study explores the anticancer effects of Cucurbitacin-B (Cur-B), a triterpenoid compound found in the Cucurbitaceae family, on androgen-dependent prostate cancer LNCaP cells. The results show that Cur-B inhibits cell viability, induces apoptosis and cell cycle arrest, and reduces the expression of the Notch signaling cascade in LNCaP cells. Cur-B has the potential to be a promising therapeutic agent for androgen-dependent prostate cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Aktan Alpsoy, Sagar M. Utturkar, Benjamin C. Carter, Alisha Dhiman, Sandra E. Torregrosa-Allen, Melanie P. Currie, Bennett D. Elzey, Emily C. Dykhuizen
Summary: The SWI/SNF chromatin-remodeling complexes, particularly the GBAF subcomplex, play a critical role in prostate cancer by interacting with AR and CTCF, modulating AR-dependent gene expression, and exhibiting overlapping genome localization and transcriptional targets with BET proteins. Targeting the BRD9 subunit of GBAF complex may provide a promising alternative for treating AR-positive prostate cancers, including those resistant to androgen deprivation therapies, by coordinating SWI/SNF-BET cooperation.
Article
Cell Biology
Jin Xu, Weixue Xu, Xuan Yang, Zhen Liu, Qinyun Sun
Summary: This study revealed that overexpression of lncRNA HCG11 in pancreatic carcinoma samples promoted cancer growth and aggressiveness, while inhibiting apoptosis. Knockdown of HCG11 suppressed the progression of pancreatic carcinoma cells. Bioinformatics analysis showed that HCG11 upregulated MDM2 expression by competitively targeting miR-579-3p. These findings suggest that HCG11 plays a significant role in the progression of pancreatic carcinoma.
Article
Oncology
Xiaojing Zhang, Huiqin Bian, Wei Wei, Qian Wang, Jinnan Chen, Ruoxuan Hei, Chen Chen, Xuan Wu, Haochun Yuan, Junxia Gu, Yaojuan Lu, Cheguo Cai, Qiping Zheng
Summary: DLX5 plays essential roles in bone development and oncogenesis. This study investigated its effect on osteosarcoma progression, revealing that DLX5 promotes OS cell growth and progression, potentially through activation of the NOTCH signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Immunology
Ngoc-Niem Bui, Chen-Yi Li, Ling-Yu Wang, Yu-An Chen, Wei-Hsiang Kao, Li-Fang Chou, Jer-Tsong Hsieh, Ho Lin, Chih-Ho Lai
Summary: Prostate cancer is a common malignancy in men, and its mortality has been increasing globally. This study investigated the effect of C. scindens, a member of the gut microbiota, on the progression of prostate cancer. The results showed that metabolites derived from C. scindens promoted the proliferation and migration of prostate cancer cells, accompanied by the activation of the androgen receptor (AR). These findings suggest that C. scindens may contribute to prostate cancer progression via the activation of AR signaling.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Gastroenterology & Hepatology
Saiko Marui, Yoshihiro Nishikawa, Masahiro Shiokawa, Masataka Yokode, Shimpei Matsumoto, Yuya Muramoto, Sakiko Ota, Takeharu Nakamura, Hiroyuki Yoshida, Hirokazu Okada, Takeshi Kuwada, Tomoaki Matsumori, Katsutoshi Kuriyama, Akihisa Fukuda, Dieter Saur, Takashi Aoi, Norimitsu Uza, Yuzo Kodama, Tsutomu Chiba, Hiroshi Seno
Summary: The roles of HES1 in the adult pancreas and pancreatic cancer are context-dependent. HES1 is not required for maintaining the adult pancreas under normal conditions, but is important for regeneration during recovery from pancreatitis. Furthermore, HES1 promotes early lesion formation while inhibiting the progression of late lesions in pancreatic cancer.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Clinical Neurology
Jessica Camacho, Alberto Rabano, Paula Marazuela, Anna Bonaterra-Pastra, Garazi Serna, Teresa Moline, Santiago Ramon y Cajal, Elena Martinez-Saez, Mar Hernandez-Guillamon
Summary: Genome-wide association studies have identified several genes as genetic susceptibility loci for Alzheimer's disease, with CD2AP being one of them. CD2AP was found to be present in brain endothelial cells and neuronal inclusions in AD cases, showing association with tau pathology. The distribution of CD2AP in neurons was correlated with Braak neurofibrillary stage, suggesting a link between CD2AP expression and tau-related diseases.
Article
Biochemistry & Molecular Biology
Carolina Belmar-Lopez, Georges Vassaux, Ana Medel-Martinez, Jerome Burnet, Miguel Quintanilla, Santiago Ramon Y. Cajal, Javier Hernandez-Losa, Antonio de la Vieja, Pilar Martin-Duque
Summary: This study investigates the safety and application of intravenous-injected mesenchymal stem cells (MSCs) in animals with different inflammatory pathologies. The results show that MSCs can migrate to different organs and have the ability to deliver adenoviruses to tumors. Mechanisms such as transdifferentiation, fusion, and paracrine processes after MSCs homing were also studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Clinical Neurology
Jesus Juega, Carlos Palacio, Carlos Pinana, Maite Rodriguez, Matias Deck, Teresa Moline, Jessica Camacho, Pedro Cardona, Helena Quesada, Maria Hernandez-Perez, Laura Dorado, Manuel Requena, Garcia-Tornel Alvaro, Noelia Rodriguez-villatoro, Marta Olive, Sandra Boned, Marian Muchada, Prudencio Lozano, Li Jiahui, Marta Rubiera, Alejandro Tomasello, David Hernandez, Marta De Dios, Santiago Ramon y Cajal, Marc Ribo, Jose A. Sabin, Carlos A. Molina, Jorge Pagola
Article
Clinical Neurology
Jesus Juega, Carlos Palacio-Garcia, Maite Rodriguez, Matias Deck, David Rodriguez-Luna, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, Marta Rubiera, Sandra Boned, Marian Muchada, Marc Ribo, Carlos Pinana, David Hernandez, Pilar Coscojuela, Humberto Diaz, Estela Sanjuan, Maria Hernandez-Perez, Laura Dorado, Helena Quesada, Pere Cardona, Carolina De-la-Torre, Alejandro Tomasello, Laura Gallur, Maria Sanchez, Sara Gonzalez-Rubio, Jessica Camacho, Santiago Ramon-Y-Cajal, Jose Alvarez-Sabin, Carlos A. Molina, Jorge Pagola
Summary: The study aimed to identify markers of high-risk cardioembolic etiology in patients with cryptogenic strokes by analyzing intracranial clots using flow cytometry. Monocytes and monocyte-to-lymphocyte ratio (MLr) were found to independently predict the diagnosis of high-risk cardioembolic etiology in cryptogenic strokes. In clot analysis, MLr >= 1.6 was a strong predictor of cardioembolic etiology in a multivariate model adjusted for age.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biology
Gerard Cantero-Recasens, Josune Alonso-Maranon, Teresa Lobo-Jarne, Marta Garrido, Mar Iglesias, Lluis Espinosa, Vivek Malhotra, Kelly G. Ten Hagen
Summary: Colorectal cancer cells build a barrier to chemotherapy by increasing mucins' secretion, and low levels of KChIP3 are associated with relapse risk and drug resistance in CRC patients. Inhibiting mucin secretion significantly enhances sensitivity to chemotherapy.
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Celia Gonzalez-Gil, Mireia Morgades, Thaysa Lopes, Francisco Fuster-Tormo, Jesus Garcia-Chica, Ran Zhao, Pau Montesinos, Anna Torrent, Marina Diaz-Beya, Rosa Coll, Lourdes Hermosin, Santiago Mercadal, Jose Gonzalez-Campos, Lurdes Zamora, Teresa Artola, Ferran Vall-Llovera, Mar Tormo, Cristina Gil-Cortes, Pere Barba, Andres Novo, Jordi Ribera, Teresa Bernal, Paula Lopez de Ugarriza, Maria-Paz Queipo, Pilar Martinez-Sanchez, Alicia Gimenez, Teresa Gonzalez-Martinez, Antonia Cladera, Jose Cervera, Rosa Fernandez-Martin, Maria Angeles Ardaiz, Maria Jesus Vidal, Angela Baena, Nuria Lopez-Bigas, Anna Bigas, Jaroslaw Maciejewski, Alberto Orfao, Josep Maria Ribera, Eulalia Genesca
Summary: Genetic information plays a crucial role in understanding the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), but its clinical value remains limited. Few genetic markers are associated with T-ALL patient outcomes, regardless of measurable residual disease (MRD) status. Integrated genomic and clinical data revealed a mutational profile in T-ALL patients, with DNMT3A/N/KRAS/MSH2/U2AF1 gene mutations identifying refractory/resistant patients. The presence of DNMT3A mutations in non-leukemic cells suggests mutational-driven clonal hematopoiesis. The adverse genetic profile, combined with MRD on day +35, allows risk stratification and predicts overall survival (OS) in adult T-ALL.
Article
Medicine, Research & Experimental
Violeta Garcia-Hernandez, David Arambilet, Yolanda Guillen, Teresa Lobo-Jarne, Maria Maqueda, Christos Gekas, Jessica Gonzalez, Arnau Iglesias, Nerea Vega-Garcia, Ines Sentis, Juan L. Trincado, Ian Marquez-Lopez, Holger Heyn, Mireia Camos, Lluis Espinosa, Anna Bigas
Summary: We investigated the role of beta-catenin/CTNNB1 in T-cell Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. We identified a specific gene signature regulated by beta-catenin, TCF/LEF factors, and ZBTB33/Kaiso in T-ALL cell lines, which was highly represented in refractory T-ALL patients. We demonstrated the importance of beta-catenin in RNA and protein synthesis in T-ALL and proposed combination treatments involving beta-catenin inhibitors to enhance chemotherapy response and prevent disease relapse in T-ALL patients.
EMBO MOLECULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Julia German-Cortes, Mireia Vilar-Hernandez, Diana Rafael, Ibane Abasolo, Fernanda Andrade
Summary: Nanotechnology has made significant contributions to cancer treatment by improving the effectiveness and specificity of chemotherapy through the use of nanoparticles, particularly solid lipid nanoparticles (SLNs). SLNs offer higher stability, active targeting, sustained and controlled release, and multifunctional therapy, making them an ideal drug delivery system.
Review
Pharmacology & Pharmacy
Fernanda Andrade, Julia German-Cortes, Sara Montero, Pilar Carcavilla, Diego Baranda-Martinez-Abascal, Marc Molto-Abad, Joaquin Seras-Franzoso, Zamira Vanessa Diaz-Riascos, Diana Rafael, Ibane Abasolo
Summary: Kirsten rat sarcoma (KRAS) is a small GTPase that regulates cell survival, proliferation, and differentiation. Mutations in KRAS are found in various human cancers, with the highest rates in pancreatic, colorectal, and lung cancers. These mutations are associated with poor prognosis, low survival rate, and resistance to chemotherapy. Nanomedicine offers a promising solution to improve the specificity and effectiveness of anti-KRAS therapy through the development of nanoparticles for targeted drug delivery. This article aims to summarize the recent advances in using nanotechnology for new therapeutic strategies against KRAS-mutated cancers.
Article
Chemistry, Medicinal
Maria Nuria Peralta-Moreno, Vanessa Anton-Munoz, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, Jose Manuel Granadino-Roldan, Claudia Machicado, Jaime Rubio-Martinez
Summary: Since the outbreak of the COVID-19 pandemic, there have been over 750 million reported cases of COVID-19 caused by SARS-CoV-2. In order to find effective treatments, intensive research has been conducted on therapeutic agents derived from pharmaceutical repositioning or natural products. This study focuses on identifying inhibitors for the SARS-CoV-2 M-pro main protease dimer using virtual screening of natural compounds derived from Peruvian flora. The compound Hyperoside displayed inhibitory activity against M-pro in vitro, with a K-i value lower than 20 μM, possibly through allosteric modulation.
Article
Chemistry, Multidisciplinary
Ana Garcia, Juan Antonio Camara, Ana Maria Boullosa, Muriel F. Gusta, Laura Mondragon, Simo Schwartz Jr, Eudald Casals, Ibane Abasolo, Neus G. Bastus, Victor Puntes
Summary: Injection of albumin-stabilised 5 nm CeO(2)NPs into mice enhances X-ray contrast significantly, with prolonged residence time in target organs.
Article
Pharmacology & Pharmacy
Mar Gil, Lareen Khouri, Imma Raurell, Diana Rafael, Fernanda Andrade, Ibane Abasolo, Simo Schwartz, Maria Martinez-Gomez, Maria Teresa Salcedo, Juan Manuel Pericas, Diana Hide, Mingxing Wei, Norman Metanis, Joan Genesca, Maria Martell
Summary: In this study, functionalized polymeric micelles (FPMs) loaded with simvastatin were developed as a drug delivery system to target liver sinusoidal endothelial cells (LSECs) and preserve liver function in chronic liver disease (CLD). The functionalized micelles showed greater in vivo internalization in LSECs compared to non-functionalized micelles. Treatment with FPM-Sim reduced toxicity and moderately lowered portal pressure in bile duct ligation (BDL) rats. In a less severe model of TAA-induced cirrhosis, treatment with FPM-CD32b-Sim significantly decreased portal pressure, reduced liver fibrosis, and stimulated nitric oxide synthesis.
Meeting Abstract
Medicine, Research & Experimental
Lourdes Salazar Huayna, Alexandra Navarro Jimenez, Jessica Camacho, Alfons Nadal, Joan Carles Ferreres, Javier Hernandez-Losa, Marta Sese, Teresa Moline, Lourdes Naranjo, Louis Moscoso, Santiago Ramon Y. Cajal, Marta Garrido-Pontnou
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Pathology
Lourdes Salazar Huayna, Alexandra Navarro Jimenez, Jessica Camacho, Alfons Nadal, Joan Carles Ferreres, Javier Hernandez-Losa, Marta Sese, Teresa Moline, Lourdes Naranjo, Louis Moscoso, Santiago Ramon Y Cajal, Marta Garrido-Pontnou