Article
Biochemistry & Molecular Biology
Joanna Wawszczyk, Katarzyna Jesse, Malgorzata Kapral
Summary: This study aimed to evaluate the influence of pterostilbene on the proliferation and apoptosis of melanoma cells. The results revealed that pterostilbene reduced the proliferation of melanoma cells and induced apoptosis in a portion of them, while having no effect on another type of melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wei Liu, Yacong Ji, Feng Wang, Chongyang Li, Shaomin Shi, Ruochen Liu, Qian Li, Leiyang Guo, Yaling Liu, Hongjuan Cui
Summary: This study demonstrates that morusin, a flavonoid compound isolated from Morus Alba, has anti-melanoma activity by inhibiting proliferation, inducing cell cycle arrest, promoting apoptosis, and inhibiting migration and invasion of melanoma cells. In addition, it inhibits tumor growth in vivo with limited side effects on mice. These findings expand the potential clinical use of morusin for melanoma treatment.
Article
Nanoscience & Nanotechnology
Xiaoguang You, Haiying Ren, Lijun Wen
Summary: This study demonstrates that miR-34c-5p can suppress the progression of lung adenocarcinoma by targeting the NUF2 gene. NUF2 overexpression is associated with poor prognosis, while underexpression of miR-34c-5p contributes to unfavorable outcomes.
JOURNAL OF NANOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Shunta Nagashima, Junichi Maruyama, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Makiko Nawa, Ken-Ichi Nakahama, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruhiko Sugimura, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata
Summary: CSE1L promotes the nuclear accumulation of TAZ and enhances malignancy in cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhi Liu, Aleksandar Krstic, Ashish Neve, Cristina Casalou, Nora Rauch, Kieran Wynne, Hilary Cassidy, Amanda McCann, Emma Kavanagh, Brendan McCann, Alfonso Blanco, Jens Rauch, Walter Kolch
Summary: KSR1 plays a critical role in mutant BRAF transformation, and its loss results in impaired cell proliferation and migration, cell cycle abnormalities, cellular senescence, and apoptosis. The study reveals that KSR1 directs ERK to phosphorylate substrates essential for cell survival, and its loss activates p38 MAPK pathway leading to cell cycle aberrations and senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kun Cao, Ruonan Wang, Lianhai Li, Yuting Liao, Xiao Hu, Ruixue Li, Xiuwen Liu, Xing-dong Xiong, Yanjie Wang, Xinguang Liu
Summary: Homologous recombination (HR) is a major pathway for repairing DNA double-strand breaks (DSBs), and dysfunction of DDX11 impairs HR and increases sensitivity to PARP inhibitors in HCC cells. The DDX11 Q238H mutation disrupts the interaction between RAD51 and BRCA2, leading to HR deficiency.
Article
Oncology
Annette M. Mathew, Zuliang Deng, Christian J. Nelson, Trenton G. Mayberry, Qian Bai, Marco Lequio, Emerson Fajardo, Huaping Xiao, Mark R. Wakefield, Yujiang Fang
Summary: Although artichoke has shown powerful anti-cancer effects on various types of cancer, including breast cancer, colon cancer, liver cancer, and leukemia, its effect on melanoma is not well known. This study aimed to investigate the direct impact of artichoke extract (AE) on the growth of melanoma. The results showed that AE significantly reduced the number of melanoma colonies and decreased the optical density of cancer cells. Furthermore, AE treatment led to increased apoptosis and changes in molecular mechanisms related to cell proliferation and survival. The findings suggest that artichoke inhibits the growth of melanoma by suppressing proliferation and promoting apoptosis, potentially offering a promising treatment for this lethal malignancy.
Article
Oncology
Yang Sun, Sanmao Su, Mengjun Li, Ang Deng
Summary: This study aimed to identify the molecular targets of osteoarthritis (OA) therapy, focusing on the expression and biological functions of miR-182-5p and its target genes FGF9 in OA. The results showed that miR-182-5p was upregulated in OA chondrocytes and regulated chondrocyte proliferation, apoptosis, and inflammation by targeting FGF9. miR-182-5p may be a potential gene for the treatment of OA.
ANALYTICAL CELLULAR PATHOLOGY
(2023)
Article
Oncology
Alessandro Tubita, Zoe Lombardi, Ignazia Tusa, Azzurra Lazzeretti, Giovanna Sgrignani, Dimitri Papini, Alessio Menconi, Sinforosa Gagliardi, Matteo Lulli, Persio Dello Sbarba, Azucena Esparis-Ogando, Atanasio Pandiella, Barbara Stecca, Elisabetta Rovida
Summary: This study demonstrates that targeting ERK5 induces p21-mediated cellular senescence in melanoma, revealing a potential prosenescence effect of ERK5 inhibitors for melanoma treatment.
Article
Environmental Sciences
Yongren Li, Baolu Zhang, Shuang Liang, Yongjun Guo
Summary: The study found that inhibiting the first polar body formation in fertilized Zhikong scallop eggs using cytochalasin B can significantly affect the chromosome segregation patterns, which are determined by the number of centrosomes in meiosis II.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Dominika Stencel, Anna Skorek, Klaudia Banach, Dorota Wrzesniok
Summary: Melanoma is the most dangerous form of skin cancer due to its high mortality, aggressiveness, and low effectiveness of therapy. Previous studies have shown the therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to evaluate the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic and amelanotic melanoma cell lines. The results demonstrated that tigecycline efficiently inhibited the proliferation of both types of melanoma cells, accompanied by dysregulation of the cell cycle, depolarization of the mitochondrial membrane, and alterations in various molecular levels. However, the drug induced apoptosis only in melanotic melanoma cells, while amelanotic cells exhibited resistance and showed increased autophagy marker levels.
Article
Biology
Jonay Garcia-Luis, Helene Bordelet, Agnes Thierry, Romain Koszul, Luis Aragon
Summary: This study reveals that degradation of cohesin during anaphase onset leads to aberrant chromatid segregation in yeast cells. Hi-C analysis of segregating chromatids shows that depletion of cohesin results in loss of intrachromatid organization. Surprisingly, cleavage of cohesin through specific methods does not significantly disrupt chromatid organization during anaphase, explaining successful bulk segregation.
Article
Engineering, Biomedical
Xiaohui Sun, Pengfei Yang
Summary: The study found that BRD4 expression was upregulated in psoriatic skin lesions and its inhibition could alleviate skin damage by suppressing inflammation and promoting keratinocyte apoptosis. Inhibition of BRD4 could suppress proliferation and inflammation of psoriatic keratinocytes, while promoting apoptosis.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Pharmacology & Pharmacy
Hongwu Meng, Lingfeng Jiang, Pengcheng Jia, Ruowen Niu, Fangtian Bu, Yan Zhu, Xueyin Pan, Juanjuan Li, Jinyu Liu, Yilong Zhang, Cheng Huang, Xiongwen Lv, Jun Li
Summary: This study identified a novel circRNA ASPH (circASPH) that mediates hepatic fibrosis (HF) by targeting the miR-139-5p/Notch1 axis. The expression profile of circASPH in hepatocyte exosomes of mice with HF was found to be upregulated. Downregulation of circASPH expression inhibited hepatic stellate cell (HSC) activation and proliferation, induced apoptosis, and attenuated mouse liver fibrogenic injury. Thus, circASPH may serve as a potential biomarker for HF diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)