Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression

The actin-binding and bundling protein, EPLIN, is required for cytokinesis

(2011) Vanessa Oakes et al.   CELL CYCLE

Calcineurin activity is required for the completion of cytokinesis

(2010) Megan Chircop et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ThePthaladyns: GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening

(2010) Luke R. Odell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis

(2010) Timothy A. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer Cells

(2010) S. Joshi et al.   MOLECULAR CANCER THERAPEUTICS

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

(2010) O. Jameel Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Short and long-term tumor cell responses to Aurora kinase inhibitors

(2009) Megan R. Dreier et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of Dynamin Mediated Endocytosis by theDynoles—Synthesis and Functional Activity of a Family of Indoles

(2009) Timothy A. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

(2009) M. E. Bekier et al.   MOLECULAR CANCER THERAPEUTICS

The Bcl-2 Homology Domain 3 Mimetic ABT-737 Targets the Apoptotic Machinery in Acute Lymphoblastic Leukemia Resulting in Synergistic in Vitro and in Vivo Interactions with Established Drugs

(2009) L. M. High et al.   MOLECULAR PHARMACOLOGY

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

(2008) K. Kojima et al.   BLOOD

MCF-7 breast carcinoma cells do not express caspase-3

(2008) Reiner U. Jänicke   BREAST CANCER RESEARCH AND TREATMENT

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

(2008) K A Sedelies et al.   CELL DEATH AND DIFFERENTIATION

Isoform and Splice-Variant Specific Functions of Dynamin-2 Revealed by Analysis of Conditional Knock-Out Cells

(2008) Ya-Wen Liu et al.   MOLECULAR BIOLOGY OF THE CELL

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

(2008) Jerry E. Chipuk et al.   TRENDS IN CELL BIOLOGY