Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin

How do real tumors become resistant to cisplatin?

(2011) Piet Borst et al.   CELL CYCLE

Radiation-induced DNA repair foci: Spatio-temporal aspects of formation, application for assessment of radiosensitivity and biological dosimetry

(2010) I.Y. Belyaev   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma

(2009) W. Sakai et al.   CANCER RESEARCH

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

DNA-Dependent Protein Kinase (DNA-PK)-Dependent Cisplatin-Induced Loss of Nucleolar Facilitator of Chromatin Transcription (FACT) and Regulation of Cisplatin Sensitivity by DNA-PK and FACT

(2009) J. Dejmek et al.   MOLECULAR CANCER RESEARCH

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic Lethality — A New Direction in Cancer-Drug Development

(2009) J. Dirk Iglehart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ovarian Cancer

(2008) Kathleen R. Cho et al.   Annual Review of Pathology-Mechanisms of Disease

Drug Resistance Caused by Reversion Mutation

(2008) A. Ashworth   CANCER RESEARCH

Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance

(2008) E. M. Swisher et al.   CANCER RESEARCH

Necroptosis: A Specialized Pathway of Programmed Necrosis

(2008) Lorenzo Galluzzi et al.   CELL

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation

(2008) Takuya Abe et al.   CELLULAR SIGNALLING

Platinum compounds 30 years after the introduction of cisplatin: Implications for the treatment of ovarian cancer

(2008) Franco Muggia   GYNECOLOGIC ONCOLOGY

FACT-Mediated Exchange of Histone Variant H2AX Regulated by Phosphorylation of H2AX and ADP-Ribosylation of Spt16

(2008) Kyu Heo et al.   MOLECULAR CELL

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH