Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification

Odefy -- From discrete to continuous models

(2010) Jan Krumsiek et al.   BMC BIOINFORMATICS

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computing Combinatorial Intervention Strategies and Failure Modes in Signaling Networks

(2010) Regina Samaga et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes

(2010) Leonidas G. Alexopoulos et al.   MOLECULAR & CELLULAR PROTEOMICS

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

ProMoT: modular modeling for systems biology

(2009) Sebastian Mirschel et al.   BIOINFORMATICS

Computing paths and cycles in biological interaction graphs

(2009) Steffen Klamt et al.   BMC BIOINFORMATICS

Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

(2009) Dominik M Wittmann et al.   BMC Systems Biology

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-δ gene in hepatocytes

(2009) Saira Ali et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

(2009) Julio Saez-Rodriguez et al.   Molecular Systems Biology

Rictor is a novel target of p70 S6 kinase-1

(2009) C Treins et al.   ONCOGENE

The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data

(2009) Regina Samaga et al.   PLoS Computational Biology

Flexible informatics for linking experimental data to mathematical models via DataRail

(2008) Julio Saez-Rodriguez et al.   BIOINFORMATICS

HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination

(2008) Y WU et al.   CELLULAR SIGNALLING

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

Multistability of signal transduction motifs

(2008) J. Saez-Rodriguez et al.   IET Systems Biology

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane

(2008) R. Eulenfeld et al.   JOURNAL OF CELL SCIENCE

c-Jun Controls Histone Modifications, NF- B Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene

(2008) S. Wolter et al.   MOLECULAR AND CELLULAR BIOLOGY