Integrated computational model of cell cycle and checkpoint reveals different essential roles of Aurora-A and Plk1 in mitotic entry

An iterative identification procedure for dynamic modeling of biochemical networks

(2010) Eva Balsa-Canto et al.   BMC Systems Biology

Computational systems biology of the cell cycle

(2009) A. Csikasz-Nagy   BRIEFINGS IN BIOINFORMATICS

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Systems biology: parameter estimation for biochemical models

(2009) Maksat Ashyraliyev et al.   FEBS Journal

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

(2009) John R. Pollard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dynamical effects of epigenetic silencing of 14-3-3σ expression

(2009) Julio Vera et al.   Molecular BioSystems

Logical modelling of cell cycle control in eukaryotes: a comparative study

(2009) Adrien Fauré et al.   Molecular BioSystems

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

(2009) Chun-Chao Wang et al.   Molecular Systems Biology

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis

(2009) B. Schoeberl et al.   Science Signaling

Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors

(2008) Hui-Yuan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization in computational systems biology

(2008) Julio R Banga   BMC Systems Biology

Pharmacophore Modelling and Virtual Screening for Identification of New Aurora-A Kinase Inhibitors

(2008) Xiao-Qiang Deng et al.   Chemical Biology & Drug Design

Polo-like kinase 1 reaches beyond mitosis—cytokinesis, DNA damage response, and development

(2008) Tohru Takaki et al.   CURRENT OPINION IN CELL BIOLOGY

Polo and Aurora kinases—lessons derived from chemical biology

(2008) Stephen Taylor et al.   CURRENT OPINION IN CELL BIOLOGY

Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

(2008) Akiko Seki et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

(2008) Helfrid Hochegger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops

(2008) T. Y.-C. Tsai et al.   SCIENCE

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE

On scrambled Halton sequences

(2007) Christoph Schlier   APPLIED NUMERICAL MATHEMATICS