Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pediatrics
Ramesh Radhika, Milind S. Tullu, Sunil Karande, Umair Ahmed Bargir
Summary: Major Histocompatibility Complex (MHC) Class II deficiency is a rare autosomal recessive primary immunodeficiency caused by mutations in regulatory genes of MHC Class II proteins. This case report describes a 9-month-old girl presenting with repeated pneumonia, lymphocytopenia, and absence of HLA-DR expression on B cells, which led to the diagnosis of MHC Class II deficiency. Genetic analysis identified a homozygous mutation in the RFX-5 gene. Despite the patient's unfortunate outcome, the importance of prenatal diagnosis was emphasized to the parents.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.
Article
Multidisciplinary Sciences
Lam-Kiu Fong, Matthew J. Chalkley, Sophia K. Tan, Michael Grabe, William F. DeGrado
Summary: Multicomponent immune receptors are essential complexes formed by interactions between distinct ligand-recognition and signaling subunits held together by acidic and basic residues of their transmembrane helices. Molecular dynamics simulations revealed a structurally stable carboxyl-carboxylate clamp motif and locally stable yet globally dynamic helical structures in these receptors. This dynamic structure accommodates sequence and structural variations, creating combinatorial functional diversity and supporting a signaling mechanism based on multisubunit clustering.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Marion Rambault, Florence B. Gilbert, Philippe Roussel, Alexia Tessier, Pierre Germon, Nathalie Winter, Aude Remot
Summary: Bovine mastitis, caused by bacterial infection, not only leads to economic losses and health problems in animals, but also affects their welfare. Neutrophils play a crucial role in eliminating pathogens and are responsible for the increase in somatic cell count during mastitis. Recent research reveals that a subset of neutrophils expressing major histocompatibility complex class II have regulatory capacities in cattle, providing new insights into the immune response during mastitis.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Genetics & Heredity
Jerzy K. Kulski, Shingo Suzuki, Takashi Shiina
Summary: This study identifies and characterizes polymorphic human leukocyte antigen (HLA)-class II genes, MTCO3P1 pseudogene alleles, and indels of transposable elements linked to specific HLA-class II alleles. The research also reveals unique crossover sites between SNP-poor and SNP-rich genomic segments, with significant haplotype shuffling near putative recombination hotspots.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Richel J. C. Bilderbeek, Maksim V. Baranov, Geert van den Bogaart, Frans Bianchi
Summary: This study reveals the over-presentation of membrane protein fragments in cytolytic and helper T cell responses. It also demonstrates the evolutionary conservation and lower frequency of mutations in transmembrane helices, suggesting that T cells are more tuned to respond to membrane proteins to avoid evasion by pathogens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tsukasa Oda, Ruri Nakamura, Tetsuhiro Kasamatsu, Nanami Gotoh, Keiko Okuda, Takayuki Saitoh, Hiroshi Handa, Hirokazu Murakami, Takayuki Yamashita
Summary: Chemotherapeutic agents induce increased MHC II activity in cells that present antigens intrinsically through the ATM-NF-kappa B-IRF1-CIITA pathway. Additionally, these agents also induce T-cell regulatory molecules, enhancing antigen presentation activity of APCs.
CANCER GENE THERAPY
(2022)
Article
Environmental Sciences
Jinmu Kim, Seung Jae Lee, Euna Jo, Eunkyung Choi, Minjoo Cho, Soyun Choi, Jeong-Hoon Kim, Hyun Park
Summary: This study presents a high-quality genome assembly of the Patagonian moray cod, revealing the lack of MHC class II genes but the expansion of toll-like receptors (TLRs). This provides valuable insights into the potential rationale for MHC class II deficiency in Gadiformes fish species.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Timothy D. Lash, Deyaa AbuSalim, Gregory M. Ferrence
Summary: The successful synthesis of telluracarbaporphyrins and oxacarbatripyrrin derivatives was achieved, and it was found that the tellurium-nitrogen interactions could affect the molecular conformation and stability. Structural characterization and crystallographic analysis revealed the structures and properties of these novel molecules.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Katsumi Matsuzaki
Summary: This review summarizes the major research carried out in the author's laboratory on how lipids and their inhomogeneous distributions regulate the structures and functions of antimicrobial peptides and Alzheimer's amyloid beta-protein. Also, how to detect transmembrane helix-helix and membrane protein-protein interactions and how they are modulated by lipids are discussed.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Ankur Saikia, Andries Hadeler, Pranathi Prasad, Martin Zacharias, Sebastian Springer
Summary: This study investigates the importance of peptide exchange in immunodominance and uncovers the mechanism of peptide exchange under low pH conditions. The results demonstrate that low pH triggers peptide exchange and provide insights into the individual steps of the exchange reaction.
Article
Immunology
Oyekunle J. Oladosu, Ishaku L. Haruna, Sibusiso A. Hadebe, Huitong Zhou, Jon G. H. Hickford
Summary: This study investigated the variability of the immune response-related gene BoLA-DQA1 in cattle from Nigeria and New Zealand. Ten alleles were identified using a PCR-SSCP approach, with two novel alleles reported for the first time through DNA sequencing. Overall, 12.60% of nucleotide positions analyzed were found to be variable.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Biology
Orsolya Vincze, Claire Loiseau, Mathieu Giraudeau
Summary: High MHC class I diversity is associated with significantly lower richness of haemosporidian parasites in birds, indicating more efficient protection against intracellular pathogens. However, these associations were only detected when MHC diversity was assessed using cloning, suggesting the need for further clarification on the use of different genotyping methods for MHC loci quantification.
Article
Multidisciplinary Sciences
Katherine R. Martin, Katherine L. Mansfield, Anna E. Savage
Summary: Characterizing MHC genes' polymorphism is crucial for understanding vertebrates' immune response to disease. This study explores the immunogenetic variation in sea turtles afflicted by fibropapillomatosis, a global infectious tumour disease. Extensive variation and trans-species polymorphism were recovered in MHC class I genes among green and loggerhead sea turtles. Supertyping analysis identified three functional MHC supertypes corresponding to well-supported clades in the phylogeny. Positive selection at seven amino acid sites in the class I exon was observed. One allele weakly associated with a specific tumour texture was found, suggesting a potential link between MHC diversity and disease outcome. This study highlights the importance of evaluating genetic predictors of disease, including MHC and other functional markers, in sea turtles.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anthony Nash, Rebecca Notman, Ann M. Dixon
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2015)
Article
Multidisciplinary Sciences
Emily Breeze, Natasha Dzimitrowicz, Verena Kriechbaumer, Rhiannon Brooks, Stanley W. Botchway, Jacob P. Brady, Chris Hawes, Ann M. Dixon, Jason R. Schnell, Mark D. Fricker, Lorenzo Frigerio
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemical Research Methods
Dhadchayini Jeyaharan, Philip Aston, Angela Garcia-Perez, James Schouten, Paul Davis, Ann M. Dixon
PROTEIN EXPRESSION AND PURIFICATION
(2016)
Article
Biochemistry & Molecular Biology
Dhadchayini Jeyaharan, Carla Brackstone, James Schouten, Paul Davis, Ann M. Dixon
Article
Biochemical Research Methods
Michael Chow, Meropi Sklepari, Lorenzo Frigerio, Ann M. Dixon
PROTEIN EXPRESSION AND PURIFICATION
(2018)
Article
Immunology
Ann M. Dixon, Syamal Roy
Article
Biochemistry & Molecular Biology
Muhammad Hasan, Dharmesh Patel, Natalie Ellis, Steven P. Brown, Jozef R. Lewandowski, Ann M. Dixon
JOURNAL OF MEMBRANE BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Rhiannon L. Brooks, Ann M. Dixon
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Multidisciplinary Sciences
Christine Lockey, Richard J. Edwards, David Roper, Ann M. Dixon
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Rhiannon L. Brooks, Chandni S. Mistry, Ann M. Dixon
Summary: The study found that the reticulons closely related to RTNLB13 in Arabidopsis thaliana contain curvature-sensing amphipathic helices (APH) with sequence conservation, playing an important role in ER membrane curvature. In contrast, a more distantly related branch of reticulons developed a linker between the transmembrane domain and APH, which may enhance functional flexibility.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Eleanor S. Jayawant, Jack Hutchinson, Dorota Gasparikova, Christine Lockey, Lidon Prunonosa Lara, Ciaran Guy, Rhiannon L. Brooks, Ann M. Dixon
Summary: Antibiotic resistance poses a significant threat to human health, but antimicrobial peptides show great potential for clinical use. Lynronne-1, identified in the rumen microbiome, has broad-spectrum activity against pathogens and has been studied for its structure and design of new peptides with improved activity.
Article
Biochemistry & Molecular Biology
Christine Lockey, Hannah Young, Jessica Brown, Ann M. Dixon
Summary: The transmembrane domains of human BCR are sites of strong protein-protein interactions that may play a crucial role in BCR functionality.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Christopher M. Miles, Pin-Chia Hsu, Ann M. Dixon, Syma Khalid, Gabriele C. Sosso
Summary: This paper investigates the role of cellular membranes in facilitating ice nucleation during cryopreservation and elucidates the factors affecting their ability to act as ice nucleating agents, through molecular dynamics simulations.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Eleanor S. Jayawant, Jonathan D. Beadle, Ina Wilkening, Piotr Raubo, Michael Shipman, Rebecca Notman, Ann M. Dixon
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Multidisciplinary
Stefan Roesner, George J. Saunders, Ina Wilkening, Eleanor Jayawant, Joanna V. Geden, Paul Kerby, Ann M. Dixon, Rebecca Notman, Michael Shipman