Article
Oncology
Biao Xing, Xiao-Feng Qiao, Yan-Hua Qiu, Xin Li
Summary: The study demonstrated that TMPO-AS1 is upregulated in NPC and downregulation of TMPO-AS1 inhibits the aggressiveness of NPC cells. Further investigation revealed that TMPO-AS1 acts as a sponge for miR-320a, leading to increased expression of SOX4 in NPC cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Jing Tan, Bin Liu, Lei Zhou, Jun Gao, Xin-Kun Wang, Yuan Liu, Jin-Rong Wang
Summary: The study showed that TUG1 is upregulated in bladder cancer and promotes malignant behaviors of BC cells by acting as a sponge for miR-320a, providing a potential therapeutic target for BC.
CELLULAR SIGNALLING
(2022)
Article
Ophthalmology
Xiaodan Zhu, Yan Wang, Lei Cheng, Hongyu Kuang
Summary: This study reveals that the lncNEAT1/miR-320a/HIF-1a ceRNA network promotes HG-induced ARPE-19 cell invasion and migration through the activation of the ANGPTL4/p-STAT3 pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Oncology
Xinli Dong, Yanhua Wang, Hua Zhuang, Gang An
Summary: This study investigated the therapeutic effect of Hydroxygenkwanin (HGK) on osteosarcoma and its specific molecular mechanism. The findings suggest that HGK inhibits proliferation, migration, and invasion of MG-63 and U2OS cells through the miR-320a/SOX9 axis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cell Biology
Dong Lv, Taimin Shen, Juncheng Yao, Qi Yang, Ying Xiang, Zhiwei Ma
Summary: The study revealed that the overexpression of HECTD2 and HIF-1 alpha was associated with poorer overall survival in RCC patients, and their overexpression increased RCC cell proliferation and migration while reducing apoptosis. Conversely, knocking down HECTD2 or HIF-1 alpha impeded the malignant phenotypes of RCC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fan Zhang, Hong Wu
Summary: MiR-599 is significantly downregulated in bladder cancer and its overexpression can inhibit the malignancy of BC cells, with TOP2A identified as a downstream target contributing to enhanced tumorigenesis in BC cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Liang Chen, Wencheng Li, Zhiqin Li, Yarong Song, Jun Zhao, Zhaohui Chen, Gallina Kazobinka, Lulu Li, Yifei Xing, Teng Hou
Summary: The study identified circNUDT21 as an oncogenic circular RNA that promotes bladder cancer progression through the miR-16-1-3p/MDM2/p53 axis. This suggests circNUDT21 as a potential therapeutic target for bladder cancer. CircNUDT21 regulates the proliferative and invasive abilities of bladder cancer cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, Research & Experimental
Hengzhi Du, Zhongwei Yin, Yanru Zhao, Huaping Li, Beibei Dai, Jiahui Fan, Mengying He, Xiang Nie, Cong-Yi Wang, Dao Wen Wang, Chen Chen
Summary: Studies have shown that miR-320a is increased in pancreatic beta cells in diabetes and can lead to dysfunction by promoting ROS levels, inhibiting proliferation, and inducing apoptosis. The target gene of miR-320a, MafF, plays a role in the dysfunction of pancreatic beta cells. These findings suggest that miR-320a may be a potential therapeutic target for diabetes.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Wenbiao Ren, Jiao Hu, Huihuang Li, Jinbo Chen, Jian Ding, Xiongbing Zu, Benyi Fan
Summary: miR-616-5p is upregulated in bladder cancer and promotes invasion and migration; NR2C2 is a downstream target of miR-616-5p; High expression of NR2C2 correlates with better prognosis in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
SeongHo Jo, Guanlan Xu, Gu Jing, Junqin Chen, Anath Shalev
Summary: The study suggests that miR-320a may regulate glucagon expression by directly targeting it in humans and rodents, and that the downregulation of miR-320a by high glucose can lead to increased glucagon expression. Additionally, miR-320a is significantly decreased in human islets of type 2 diabetes subjects, accompanied by increased glucagon expression.
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Jiong Zhang, Xiaojun Deng
Summary: MiR-599 can target YAP1 to inhibit proliferation and invasion and promote apoptosis in J82 cells. The high expression of miR-599 is correlated with low expression of YAP1 in J82 cells.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Richard Molnar, Laszlo Szabo, Andras Tomesz, Arpad Deutsch, Richard Darago, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Ferenc Budan, Istvan Kiss
Summary: This study investigated the effects of olive oil and TFAs on the expression patterns of miRs and mTOR in mouse liver, spleen, and kidney. Olive oil showed protective, antioxidant, and anti-inflammatory effects, while TFAs exhibited damaging, inflammatory, and carcinogenic properties. The results suggest the presence of negative feedback regulatory mechanisms between these dietary components.
Article
Biochemistry & Molecular Biology
Fuyuan Xie, Longgen Li, Yuting Luo, Rensheng Chen, Jinhong Mei
Summary: This study identified LINC00488 as an oncogenic gene in thyroid cancer, which promoted proliferation, migration, and invasion while inhibiting apoptosis of cancer cells. LINC00488 was found to regulate the miR-376a-3p/PON2 axis, suggesting a potential novel biomarker or target for thyroid cancer treatment.
BIOSCIENCE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Jian Li, Jing Qi, Yishu Tang, Huaizheng Liu, Kefu Zhou, Zheren Dai, Lehong Yuan, Chuanzheng Sun
Summary: In this study, a nanodrug system, GA-RM/GZ/PL, was used to overexpress circRNA_0001805 specifically in hepatocytes to treat NAFLD. The overexpressed circRNA_0001805 attenuated NAFLD development by suppressing lipid metabolism disorder and inflammation, targeting miR-106a-5p/miR-320a and collaboratively regulating ABCA1/CPT1. The nanocarrier GA-RM/GZ/PL targeted hepatocytes and released glycyrrhizic acid to reduce lipid accumulation in the liver, providing a synergistic effect against NAFLD-induced lipid metabolism disorder.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)