Journal
MOLECULAR BIOLOGY REPORTS
Volume 40, Issue 11, Pages 6303-6308Publisher
SPRINGER
DOI: 10.1007/s11033-013-2743-8
Keywords
MMP-2; Polymorphism; Ankylosing spondylitis; Rheumatoid arthritis; Molecular epidemiology
Categories
Funding
- National Natural Science Foundation of China [81371927]
- Nanjing Medical University Foundation for Development of Science and Technology [06NMUZ045, 2012NJMU128]
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Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are autoimmune, inflammatory diseases with substantial genetic contributions. Matrix metalloproteinase (MMP)-2, tumor necrosis factor (TNF)-alpha and NLR family pyrin domain-containing 1 (NLRP1) play important roles in the immune response. We studied the MMP-2 rs243865 C/T, TNF-alpha rs1800629 A/G, NLRP1 rs878329 C/G and NLRP1 rs6502867 C/T polymorphisms in a Chinese cohort of 520 patients with RA, 100 with AS and 520 controls. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Using the MMP-2 rs243865 CC homozygote genotype as the reference group, the CT and TT/CT genotypes were associated with significantly reduced risks of AS. However, logistic regression analyses revealed that the MMP-2 rs243865 C/T polymorphism was not associated with risk of RA. TNF-alpha rs1800629 A/G, NLRP1 rs878329 C/G and NLRP1 rs6502867 C/T polymorphisms were not associated with risk of RA or AS. These findings suggest that the MMP-2 rs243865 C/T polymorphism is associated with AS development.
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