Article
Biochemistry & Molecular Biology
Yuanyuan Zhang, Weidong Fei, Huiwen Zhang, Yi Zhou, Li Tian, Jing Hao, Yuhan Yuan, Wenlong Li, Yunjun Liu
Summary: The iridium (III) complex [Ir(bzq)(2)(PYIP)](PF6) showed significant cytotoxic activity on BEL-7402 cells, with the liposomes inducing apoptosis through intrinsic mitochondrial pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Liuqian Xu, Suning Che, Huiqing Chen, Qian Liu, Juanjuan Shi, Jianhua Jin, Yongzhong Hou
Summary: As a master transcription factor, c-Myc promotes tumor immune escape. The role of PPARγ in c-Myc-mediated tumor immune escape is unclear. This study found that the PPARγ agonist pioglitazone reduced c-Myc protein expression by inducing its ubiquitination and degradation. Additionally, pioglitazone inhibited the expression of immune checkpoint proteins PD-L1 and CD47, thus inhibiting tumor immune escape mediated by c-Myc.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jing Chen, Haimei Liu, Yichuan Chen, Huiyan Hu, Chunxia Huang, Yi Wang, Lijuan Liang, Yunjun Liu
Summary: In this article, two new iridium(III) complexes were synthesized and their anti-cancer activity was investigated. The results showed that these complexes induced apoptosis in BEL-7402 cells through ROS-mediated mitochondrial dysfunction and inhibition of the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xiang Wang, Sen Zhang, Keyan Han, Lisheng Wang, Xu Liu
Summary: This study investigates the antiproliferative and apoptosis-inducing effects of matrine derivatives, particularly ZS17, on hepatocellular carcinoma cells. ZS17 showed strong antiproliferative activity and induced apoptosis and ROS production in vitro. Mechanistic studies revealed that ZS17 activates the ROS-JNK-P53 pathway and inhibits tumor cell migration and growth in vivo. These findings suggest that ZS17 could be a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ana Martin-Sanchez, Alba Garcia-Baos, Adriana Castro-Zavala, Laia Alegre-Zurano, Olga Valverde
Summary: This study showed that early-life stress impacted the sensitivity to cannabinoids by altering the CB1 signaling pathway and emotional memory formation, leading to behavioral and molecular changes.
Article
Chemistry, Medicinal
Qing Huang, Chunlan Pu, Lun Tan, Shirui Wang, Hongjia Zhang, Su Yu, Rui Deng, Dan Luo, Xinyu Ma, Rui Li
Summary: c-Myc protein, aberrantly expressed in colorectal cancer, can be effectively inhibited by a compound called B13. B13 not only suppresses the proliferation and migration of CRC cells, but also interferes with the expression of apoptosis pathway-related proteins. Additionally, B13 shows strong inhibition of tumor growth in animal models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dongchen An, Steve Peigneur, Jan Tytgat
Summary: The coupling of cannabinoid receptors, CB1 and CB2, to G protein-coupled inward rectifier potassium channels, GIRK1 and GIRK2, modulates neuronal excitability in the human brain. WIN55,212-2, a non-selective agonist of CB1 and CB2, activates CB1 and CB2 at low concentrations and blocks GIRK1/2 at high concentrations.
Article
Biochemistry & Molecular Biology
Jorge Antonio Silva-Gomez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Hipolito Otoniel Miranda-Roblero, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: The study evaluated the effects of PFD on early stages of liver cancer development, showing that PFD can prevent tissue damage, reduce fibrosis and inflammation, and promote apoptosis in the experimental model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Ji Eon Park, Ji Hoon Jung, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Woon Yi Park, Bum Sang Shim, Seong-Gyu Ko, Sung-Hoon Kim
Summary: The study revealed that Sanggenon G (SanG) can inhibit the viability of non-small lung cancer cells through multiple pathways, including inhibition of cyclins and apoptosis-related proteins. Additionally, SanG can induce apoptosis by activating caspase-3 and RPL5, showing potential for combination with other drugs.
PHYTOTHERAPY RESEARCH
(2021)
Article
Oncology
Yong Hao, Shuwei Bai, Jing Peng, Ronghua Hong, Jie Ding, Zezhi Li, Yangtai Guan
Summary: The study suggests that TRIM27 mediates ubiquitination of PPAR gamma, leading to increased expression of cleaved Caspase-3 and IL-1 beta, promoting Glu-induced apoptosis and IL-1 beta release in HT22 cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hye-Young Seo, So-Hee Lee, Ji Yeon Park, Eugene Han, Sol Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Summary: This study demonstrates the potential of lobeglitazone in inhibiting liver inflammation and fibrosis by reducing NLRP3 inflammasome activation and production of proinflammatory cytokines.
Article
Oncology
Ping Yu, Rui Wu, Zunchun Zhou, Xin Zhang, Ruoshu Wang, Xueting Wang, Sen Lin, Jihong Wang, Li Lv
Summary: The study demonstrated that rAj-Tspin induced apoptosis in BEL-7402 cells through a mitochondria-dependent pathway, disrupted EMT to reduce cell migration and invasion, and potentially inhibited cell proliferation and metastasis through the ITGB1-FAK-AKT pathway.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Toxicology
Zacharias Pandelides, Neelakanteswar Aluru, Cammi Thornton, Haley E. Watts, Kristine L. Willett
Summary: The study using zebrafish model revealed differential gene expression in response to THC and CBD exposure, with Cnr receptors and PPAR gamma playing crucial roles in developmental toxicities of cannabinoids, with Cnr1 being the most critical.
TOXICOLOGICAL SCIENCES
(2021)
Article
Biology
Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki-Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve, Thomas Rudel, Sophie Helaine
Summary: IFN-γ downregulates c-Myc to activate L-tryptophan metabolism, leading to persistent Chlamydia trachomatis infection. Additionally, tryptophan concentration controls c-Myc levels via the PI3K-GSK3β axis, and results in the rewiring of the host cell tricarboxylic acid cycle.
Article
Biochemistry & Molecular Biology
Yoshiro Hirasaki, Atsushi Okabe, Masaki Fukuyo, Bahityar Rahmutulla, Yasunobu Mano, Motoaki Seki, Takayuki Hoshii, Takao Namiki, Atsushi Kaneda
Summary: This study found that cinobufagin can induce apoptosis in human acute myeloid leukaemia cells and has inhibitory effects on c-Myc. Transcriptomic analysis and gene set enrichment analysis further revealed its mechanisms of action.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Genetics & Heredity
Yue-Hui Hong, Mao-Cheng Deng, Xiao-Ming Xu, Chou-Fei Wu, Xi Xiao, Qing Zhu, Xian-Xian Sun, Qian-Zhi Zhou, Juan Peng, Jian-Ping Yuan, Jiang-Hai Wang
Article
Biotechnology & Applied Microbiology
M. -C. Deng, J. Li, Y. -H. Hong, X. -M. Xu, W. -X. Chen, J. -P. Yuan, J. Peng, M. Yi, J. -H. Wang
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Fisheries
Fu-Rui Liang, Yue-Hui Hong, Cong-Cong Ye, Hailin Deng, Jian-Ping Yuan, Yun-Fang Hao, Jiang-Hai Wang
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Lian-Xian Guo, Xiao-Ming Xu, Yue-Hui Hong, Yan Li, Jiang-Hai Wang
Article
Microbiology
Yue-Hui Hong, Cong-Cong Ye, Qian-Zhi Zhou, Xiao-Ying Wu, Jian-Ping Yuan, Juan Peng, Hailin Deng, Jiang-Hai Wang
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Ai-Juan Feng, Xi Xiao, Cong-Cong Ye, Xiao-Ming Xu, Qing Zhu, Jian-Ping Yuan, Yue-Hui Hong, Jiang-Hai Wang
Article
Biochemistry & Molecular Biology
Fu-Rui Liang, Hui-Shi He, Chu-Wen Zhang, Xiao-Ming Xu, Zhao-Ping Zeng, Jian-Ping Yuan, Yue-Hui Hong, Jiang-Hai Wang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Multidisciplinary Sciences
Lian-Xian Guo, Yue-Hui Hong, Qian-Zhi Zhou, Qing Zhu, Xiao-Ming Xu, Jiang-Hai Wang
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Yingjie Xia, Yuanfei Deng, Yuting Zhou, Dan Li, Xuemeng Sun, Lei Gu, Zipeng Chen, Qing Zhao
CELL BIOCHEMISTRY AND FUNCTION
(2020)
Article
Microbiology
Yue-Hui Hong, Zhan-Hua Mai, Cheng-Ji Li, Qiu-Yi Zheng, Lian-Xian Guo
Summary: This study analyzed the microbial diversities of fertilized Thitarodes eggs from different Chinese cordyceps occurrence sites using gene sequencing techniques. The results showed significant differences in bacterial communities among the eggs, while fungal differences were not as significant. Wolbachia, Spiroplasma, and Purpureocillium were inferred to be closely related to Chinese cordyceps occurrence.
CURRENT MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuting Zhou, Zhongping Liang, Yingjie Xia, Shuai Li, Jiali Liang, Zhixiang Hu, Chengbin Tang, Qing Zhao, Qing Gong, Yongchang Ouyang
Summary: This study identifies RBMS3 as a crucial regulator of PD-L1 in triple-negative breast cancer. RBMS3 binds to CD274 mRNA, stabilizing PD-L1 levels and promoting cell migration. Combining RBMS3 inhibition with auranofin enhances anti-tumor T-cell immunity and improves the efficacy of cancer immunotherapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Limnology
Xu Xiaoming, Hong Yuehui, Zhou Qianzhi, Liu Jinzhong, Yuan Lirong, Wang Jianghai
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2018)
Article
Limnology
Zhu Qing, Lin Jia, Hong Yuehui, Yuan Lirong, Liu Jinzhong, Xu Xiaoming, Wang Jianghai
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2018)
Article
Limnology
Lin Jia, Zhu Qing, Hong Yuehui, Yuan Lirong, Liu Jinzhong, Xu Xiaoming, Wang Jianghai
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2018)