Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Rheumatology
Hui-Min Li, Yi Liu, Ren-Jie Zhang, Jing-Yu Ding, Cai-Liang Shen
Summary: Our meta-analysis indicates that VDR BsmI and TaqI polymorphisms are associated with OA susceptibility in the spine and the FokI polymorphism is associated with knee OA susceptibility. However, the ApaI polymorphism is not a significant genetic risk factor for OA. Ethnic stratification also showed no significant association between VDR gene polymorphisms and OA in Caucasians or Asians.
Review
Nutrition & Dietetics
Elena Formisano, Elisa Proietti, Consuelo Borgarelli, Livia Pisciotta
Summary: Psoriasis is a chronic immune-dysregulated inflammatory disease and low vitamin D levels are associated with it. This study reviewed the relationship between vitamin D, bone metabolism parameters, and psoriasis, as well as evaluated the effectiveness of oral vitamin D supplementation. The results showed that psoriasis patients had lower levels of 25(OH)D and parathormone compared to controls. However, vitamin D supplementation did not seem to improve clinical manifestations in psoriasis patients.
Review
Medicine, General & Internal
Maoquan Yang, Wansheng Ji, Ning Xu, Chuanju Zong, Jinhua Gu, Xiaojing Guo, Li Zhang
Summary: In this meta-analysis, VDR gene polymorphisms including Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI were found to be significantly associated with colorectal cancer (CRC) risk. Specifically, the BsmI variant was associated with a lower risk of CRC in Caucasian population, the FokI polymorphism was associated with colon cancer risk, and the Cdx-2 polymorphism was associated with decreased CRC risk among Africans.
Article
Multidisciplinary Sciences
Fei Ju, Ruonan Zhu
Summary: This meta-analysis found that lower vitamin D levels are associated with allergic rhinitis, and vitamin D supplementation might be beneficial in addition to standard treatment. Furthermore, the VDR gene variant rs2228570 was also found to be associated with the development of rhinitis, requiring further research for confirmation.
Review
Medicine, General & Internal
Qian Li, Wen Li, Menglu Chen, Yihui Chai, Liancheng Guan, Yunzhi Chen
Summary: This study, through a meta-analysis of relevant research, found that VDR Fok I gene polymorphism is closely associated with susceptibility to sepsis, and patients with sepsis have lower levels of 25-hydroxyvitamin D. VDR Fok I gene mutations may change the risk of sepsis.
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Review
Medicine, General & Internal
Xiaofeng Li, Xianghai Gan, Junzuo Gong, Tianyi Mou, Hua Zhou, Mengqin Li
Summary: This meta-analysis aims to summarize the association between BsmI, ApaI, TaqI, and FokI polymorphisms and the risk of acute pancreatitis, with results to be submitted to a peer-reviewed journal for publication.
Review
Nutrition & Dietetics
Tanya Shree, Pratibha Banerjee, Sabyasachi Senapati
Summary: This study found that vitamin D metabolism and genetic polymorphisms of VDR are associated with the development of CD. Healthy controls have significantly higher levels of 25(OH)D serum than CD patients, and the T-allele of Fok1 is a predisposing allele for CD. The results of this study suggest that reduced serum levels of 25(OH)D and the Fok1 T-allele of VDR play a critical role in immunomodulation and maintaining barrier integrity, which are majorly implicated in CD.
FRONTIERS IN NUTRITION
(2023)
Article
Dermatology
Young Ho Lee, Gwan Gyu Song
Summary: This study found a correlation between VDR ApaI and BsmI polymorphisms and vitiligo susceptibility in the Asian population, while no association was observed for TaqI and FokI polymorphisms in European, Asian, Arab, and Latin American populations.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Adam Maciejewski, Katarzyna Lacka
Summary: Vitamin D plays a crucial role in immunity and differentiation/proliferation processes, and it is potentially associated with thyroid cancer. This study systematically reviewed publications on the association between vitamin D-related gene variants and thyroid cancer. Results were inconclusive, and further validation is required.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Samira Tabaei, Morteza Motallebnezhad, Seyedeh Samaneh Tabaee
Summary: This study analyzed the association between VDR gene polymorphisms and CAD risk, finding that FokI and ApaI SNPs were associated with an increased risk of CAD in both Asian and European populations.
BIOCHEMICAL GENETICS
(2021)
Article
Pediatrics
Yong Zhou, Sheng Li
Summary: This systematic review investigated the potential relationship between vitamin D receptor (VDR) gene polymorphisms and childhood asthma. The study found that FokI and TaqI polymorphisms were significantly associated with childhood asthma susceptibility, while ApaI and BsmI polymorphisms were not.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Sepideh Zununi Vahed, Elham Ahmadian, Peyman Foroughi, Soroush Mostafavi, Henning Madry, Mohammadreza Ardalan, Magali Cucchiarini
Summary: The study revealed a significant association between VDR and VDBP gene polymorphisms with renal allograft rejection and viral infection, showing differences in G allele frequencies among different groups.
Review
Dentistry, Oral Surgery & Medicine
Fulan Du, Zhen Liu, Song Qing
Summary: This study found significant associations between VDR gene polymorphisms of BsmI, FokI, and ApaI and the risk of severe periodontitis in the Chinese population, while TaqI polymorphism showed no significant association.
ARCHIVES OF ORAL BIOLOGY
(2022)
