Article
Multidisciplinary Sciences
Dong Wang, Liqun He, Xiaotian Zhang
Summary: The meta-analysis found a significant association between -308G/A polymorphism of TNF-alpha gene and metabolic syndrome. The A allele was associated with an increased risk of MS in the Asia group, but a decreased risk in the Europe group. Different ethnic groups may play different roles in the association between TNF-alpha gene polymorphism and MS.
SCIENTIFIC REPORTS
(2021)
Review
Environmental Sciences
Xin Gao, Di Yan, Guangying Li, Yu Wei, Huan He, Jinxia Zhai
Summary: This meta-analysis explored the relationship between polychlorinated biphenyls (PCBs) and metabolic syndrome (MetS). The results suggested that PCBs may not be a risk factor for MetS, but their high heterogeneity indicates that they are under-represented. Furthermore, total PCBs were found to be a protective factor against diabetes. Subgroup analysis revealed that different types and congerners of PCBs have varying effects on the risk of MetS and diabetes. Therefore, more high-quality research is needed to further understand the role of different species and congerners of PCBs in MetS and diabetes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Katharina Richard, Kurt H. Piepenbrink, Kari Ann Shirey, Archana Gopalakrishnan, Shreeram Nallar, Daniel J. Prantner, Darren J. Perkins, Wendy Lai, Alexandra Vlk, Vladimir Y. Toshchakov, Chiguang Feng, Rachel Fanaroff, Andrei E. Medvedev, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: This study identified homologous substitutions of two SNPs in murine Tlr4, which are associated with human TLR4, using advanced protein modeling techniques. By creating a knock-in strain expressing these SNPs and studying their effects on TLR4 signaling, the research provided new insights into how these SNPs decrease TLR4 signaling efficiency and offered an experimental approach to validate or refute human data.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Genetics & Heredity
Marcos Jesse Abrahao Silva, Davi Silva Santana, Leticia Gomes de Oliveira, Ellerson Oliveira Loureiro Monteiro, Luana Nepomuceno Gondim Costa Lima
Summary: This review analyzed the association between TLR4 gene polymorphism and susceptibility or protection in different infectious diseases. The meta-analysis found a significant association between TLR4 variant rs4986790 and increased risk of viral infections, but no significant association with bacterial or parasitic infections.
FRONTIERS IN GENETICS
(2022)
Article
Nutrition & Dietetics
Martin Ming Him Wong, Kwan Yi Chan, Kenneth Lo
Summary: This review examines the association between dietary and environmental manganese exposure and the risk of metabolic syndrome (MetS). The findings suggest that the levels of manganese from diet, serum, urine, and whole blood do not have a significant association with MetS. However, some studies indicate a non-linear relationship between urinary and blood manganese levels and MetS, and higher dietary manganese may be associated with a lower MetS risk in certain studies.
Review
Environmental Sciences
Hugo Lamat, Marie-Pierre Sauvant-Rochat, Igor Tauveron, Reza Bagheri, Ukadike C. Ugbolue, Salwan Maqdasi, Valentin Navel, Frederic Dutheil
Summary: The study found that there is a relationship between pesticide exposure and metabolic syndrome. Exposure to pesticides and their contaminants increases the risk of metabolic syndrome, especially for organochlorines. The use of pesticides worldwide may be increasing over time. There is also an inverse relationship between body mass index and male gender.
ENVIRONMENTAL POLLUTION
(2022)
Review
Immunology
Sara Russo, Marcel Kwiatkowski, Natalia Govorukhina, Rainer Bischoff, Barbro N. Melgert
Summary: Type II diabetes and obesity are associated with metabolic inflammation, where macrophages play a significant role in development. Metabolic reprogramming of macrophages may lead to unique activation patterns in diabetes and obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Nahal Habibi, Aya Mousa, Chau Thien Tay, Mahnaz Bahri Khomami, Rhiannon K. Patten, Prabha H. Andraweera, Molla Wassie, Jared Vandersluys, Ali Aflatounian, Tina Bianco-Miotto, Shao J. Zhou, Jessica A. Grieger
Summary: Gestational diabetes is associated with adverse outcomes for both the mother and child. Higher levels of individual lipids and a clustering of metabolic risk factors increase the risk of gestational diabetes. Early pregnancy assessment of glucose or the metabolic syndrome offers an opportunity for prevention and treatment of individual risk factors.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Review
Environmental Sciences
Ping Xu, Aiping Liu, Fengna Li, Alexey A. Tinkov, Longjian Liu, Ji-Chang Zhou
Summary: Research has found a positive association between heavy metal exposure and MetS, with participants exposed to heavy metals having a higher likelihood of developing MetS. Further studies are needed to explore the effects of individual metals and their interactions on the relationship between MetS and heavy metals.
ENVIRONMENTAL POLLUTION
(2021)
Review
Endocrinology & Metabolism
Tingting Che, Cheng Yan, Dingyuan Tian, Xin Zhang, Xuejun Liu, Zhongming Wu
Summary: The study found that both short and long sleep significantly increased the risk of metabolic syndrome, with a U-shaped relationship between sleep duration and metabolic syndrome risk. Both short and long sleep increased the risk of obesity and high blood pressure, while short sleep may also increase the risk of high blood sugar.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Lei Zhong, Jifeng Liu, Shuo Liu, Guang Tan
Summary: This meta-analysis examines the correlation between metabolic syndrome (MetS) and pancreatic cancer. The results show that MetS is strongly associated with an increased risk of developing pancreatic cancer. This association holds true regardless of gender, and hypertension, hyperglycemia, and low HDL-c levels contribute to this relationship. However, obesity and hypertriglyceridemia are not independently related to pancreatic cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Chenyu Zhang, Xiaotong Gao, Yutong Han, Weiping Teng, Zhongyan Shan
Summary: The study found a significant association between TNs and MetS, with higher prevalence in MetS patients compared to controls, independent of sex and age. The pooled TNs prevalence in MetS patients was 45%.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Rebuma Belete, Zerihun Ataro, Ahmedmenewer Abdu, Merga Sheleme
Summary: This study aimed to estimate the prevalence of metabolic syndrome among type 1 diabetes mellitus patients. The pooled prevalence was 23.7%, with variations across geographical regions and genders. Attention should be given to prevention and control strategies to reduce the morbidity and mortality associated with metabolic syndrome in this population.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Nutrition & Dietetics
Shaoyue Jin, Youjin Je
Summary: Dairy consumption is inversely associated with the risk of metabolic syndrome, with higher intake of milk and yogurt associated with lower risk, while no significant association was found for cheese consumption.
Review
Oncology
Jia Fu, Jinqiong Jiang, Kanghan Liu
Summary: Metabolic syndrome (MetS) is associated with poor overall survival (OS) and progression-free survival (PFS) in patients with hepatocellular carcinoma (HCC), especially after radical hepatectomy. A systematic review and meta-analysis revealed that patients with MetS had worse OS and PFS compared to those without MetS.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Natalia I. Faccinetti, Luciano L. Guerra, Alberto Penas Steinhardt, Ruben F. Iacono, Gustavo D. Frechtel, Liliana Trifone, Edgardo Poskus, Aldana Trabucchi, Silvina N. Valdez
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Cell Biology
Fiorella S. Belforte, Alexandra M. Targovnik, Rodolfo M. Gonzalez-Lebrero, Carolina Osorio Larroche, Cintia E. Citterio, Rogelio Gonzalez-Sarmiento, Maria V. Miranda, Hector M. Targovnik, Carina M. Rivolta
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Oncology
Nazarena E. Ferreyra Solari, Fiorella S. Belforte, Lucia Canedo, Guillermo A. Videla-Richardson, Joaquin M. Espinosa, Mario Rossi, Eva Serna, Miguel A. Riudavets, Horacio Martinetto, Gustavo Sevlever, Carolina Perez-Castro
Article
Cell Biology
Fiorella S. Belforte, Cintia E. Citterio, Graciela Testa, Maria Cecilia Olcese, Gabriela Sobrero, Mirta B. Miras, Hector M. Targovnik, Carina M. Rivolta
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Multidisciplinary Sciences
Andrea Elena Iglesias Molli, Alberto Penas Steinhardt, Ariel Pablo Lopez, Claudio Daniel Gonzalez, Jorge Vilarino, Gustavo Daniel Frechtel, Gloria Edith Cerrone
Article
Cardiac & Cardiovascular Systems
M. L. Tellechea, A. Penas Steinhardt, G. Rodriguez, M. J. Taverna, E. Poskus, G. Frechtel
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2013)
Article
Paleontology
Roberto R. Pujana, Leandro C. A. Martinez, Juan L. Garcia Massini, Osvaldo Di Iorio, Alberto Penas Steinhardt
REVISTA BRASILEIRA DE PALEONTOLOGIA
(2014)
Article
Endocrinology & Metabolism
Silvina Yohena, Alberto Penas-Steinhardt, Clara Muller, Natalia Faccinett, Gloria E. Cerrone, Silvia Lovecchio, Edgardo Ridner, Silvina Valdez, Gustavo Frechtel
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2019)
Article
Microbiology
Fiorella Sabrina Belforte, Natalie Fernandez, Francisco Tonin Monzon, Ayelen Daiana Rosso, Sofia Quesada, Maria Cecilia Cimolai, Andrea Millan, Gloria Edith Cerrone, Gustavo Daniel Frechtel, Remy Burcelin, Federico Coluccio Leskow, Alberto Penas-Steinhardt
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Ignacio Dei-Cas, Florencia Giliberto, Leonela Luce, Hernan Dopazo, Alberto Penas-Steinhardt
SCIENTIFIC REPORTS
(2020)
Article
Marine & Freshwater Biology
G. A. de Diego, A. Penas-Steinhardt, J. P. Ferro, M. J. Palacio, N. A. Ossana, B. L. Eissa, F. Belforte
Summary: Freshwater contamination by arsenic is a global problem. This study evaluated the effect of arsenic on the biofilm microbiota structure in Naveira stream, Argentina. High concentrations of arsenic significantly affected the taxonomic composition of the bacterial community.
AQUATIC TOXICOLOGY
(2022)
Article
Microbiology
Ayelen D. Rosso, Pablo Aguilera, Sofia Quesada, Florencia Mascardi, Sebastian N. Mascuka, Maria C. Cimolai, Jimena Cerezo, Renata Spiazzi, Carolina Conlon, Claudia Milano, Gregorio M. Iraola, Alberto Penas-Steinhardt, Fiorella S. Belforte
Summary: Inflammatory bowel disease (IBD) presents a notable diagnostic challenge due to its clinical heterogeneity and treatment responses, especially in underdeveloped countries. This study characterized epigenetic biomarkers and gut microbial profiles in UC and CD patients in the Buenos Aires Metropolitan area for the first time, revealing differences between non-IBD controls and IBD patients.
Article
Pediatrics
Rosa E. Enacan, Maria E. Masnata, Fiorella Belforte, Patricia Papendieck, Maria C. Olcese, Sofia Siffo, Laura Gruneiro-Papendieck, Hector Targovnik, Carina M. Rivolta, Ana E. Chiesa
ARCHIVOS ARGENTINOS DE PEDIATRIA
(2017)