Review
Medicine, General & Internal
Xikai Wang, Qinghe Meng, Yuanyuan Wang, Yanlu Gao
Summary: High expression of MMP14 is associated with shorter overall survival and worse clinicopathological features in patients with gastric cancer. MMP14 could serve as a prognostic factor and potential therapeutic target for gastric cancer. Data from TCGA and GEO further support the association of MMP14 expression with poor prognosis in gastric cancer.
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Yuefeng Chen, Xinnan Pan, Baoming Tian, Yajun Hu
Summary: Polysaccharides have various biological activities, including tumor suppression by regulating the polarization of tumor-associated macrophages. In this study, the correlation between CD24 expression and colorectal cancer (CRC) was investigated. The results showed that CD24 expression was significantly correlated with advanced nuclear grade, lymph node metastasis, Duke's stage, and age of CRC patients.
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Jie He, Wei Luo, Yuanyuan Huang, Lingmeng Song, Yang Mei
Summary: This study aimed to evaluate the promise of sarcopenia as a prognostic indicator in individuals with colorectal cancer. Through systematic search and analysis of the literature, it was found that sarcopenia is associated with survival rates and disease-free survival rates in colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Paola Del Prete, Francesco Perri, Stefania Scala, Michele Caraglia, Guglielmo Nasti
Summary: High expression of CXCR4 is clearly associated with increased risk of death and progression in colorectal cancer. However, methodologic heterogeneity in CXCR4 assessment hinders direct translation into clinical practice, indicating the need for a consensus to streamline detection and scoring of CXCR4 expression in colorectal cancer.
Review
Oncology
Minghao Cai, Zhongyan Gao, Junyi Liao, Yuanping Jiang, Yong He
Summary: The study found that regardless of differences in frailty screening and treatment approaches, outcomes for frailty patients were less favorable in all studies. Compared with the non-frail group, the frail group had higher mortality, more serious complications, more postoperative blood transfusions and delirium, and more support outside the home.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Physical
Lavanya Anumula, Sindhu Ramesh, Venkata Suneel Kumar Kolaparthi, Richard Kirubakaran, Mohmed Isaqali Karobari, Suraj Arora, Ahmed A. Saleh, Omir Aldowah, Pietro Messina, Giuseppe Alessandro Scardina
Summary: The present study aimed to systematically review the effects of natural cross-linkers on immediate and long-term tensile bond strength and concluded that Proanthocyanidin is the most efficient natural cross-linker to date, preserving bond strength even after ageing.
Article
Multidisciplinary Sciences
Mi-Kyoung Seo, Hyundeok Kang, Sangwoo Kim
Summary: This study developed a novel method to predict microsatellite instability (MSI) in colorectal cancer (CRC) using transcriptomic profile and tumor microenvironment (TME). The method showed robustness and predictive power in predicting MSI status and has additional advantages compared to existing classifiers and other cancer types.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yingying Zhang, Siying He, Lisha Yu, Chao Shi, Yanyue Zhang, Shiyue Tang
Summary: This meta-analysis aimed to evaluate the prognostic value of HLA-G in colorectal cancer (CRC) patients based on published literature and The Cancer Genome Atlas (TCGA) datasets. The results showed that HLA-G expression was significantly associated with poor overall survival in CRC patients. However, the prognostic significance was inconsistent with the TCGA data. Further research is needed to clarify the prognostic role of HLA-G in CRC.
Article
Medicine, General & Internal
Jie Zhang, Lei Xu, Jingjun Zhang, Ying Liu, Xiang Li, Tao Ren, Hairong Liu
Summary: Through comprehensive bioinformatics analysis, we investigated MMP9 expression in different cancers, correlations between MMP9 expression and cancer prognosis and gene mutations, and relationships between MMP9 expression and immune cell infiltration. The results showed that MMP9 was highly expressed in most malignant cancers and significantly associated with the clinical prognosis of patients with different types of cancer. Furthermore, MMP9 expression correlated significantly with infiltrating cells and the expression levels of immune checkpoint genes. This pan-cancer analysis provides comprehensive information on the potential value of MMP9 as a theranostic biomarker.
Review
Medicine, General & Internal
Huaiyan Jiang, Yang Gao, Zhen Chen, Hongxia Xu
Summary: This study provides updated evidence for the evaluation of the relationship between MMP-2 polymorphism and cataract risk, offering high-quality and evidence-based medical evidence for the correlation between MMP-2 polymorphisms and cataract risks.
Article
Oncology
Pauliina Reijonen, Reetta Peltonen, Taina Tervahartiala, Timo Sorsa, Helena Isoniemi
Summary: This study found that high levels of MMP-8 were associated with worse 10-year overall survival in colorectal cancer patients with liver metastases, while high postoperative levels of MPO were associated with better 5-year disease-free survival. CEA, CA19-9, and CRP were also found to be prognostic markers in this population.
Article
Oncology
Reetta Peltonen, Jaana Hagstrom, Taina Tervahartiala, Timo Sorsa, Caj Haglund, Helena Isoniemi
Summary: This study found that high expression of MMP-9 in colorectal tumor tissue was associated with better disease-free survival (DFS), while high preoperative MPO in serum was associated with improved DFS and overall survival (OS) in patients undergoing liver resection for colorectal cancer. The prognostic significance varied according to gender, age, and the synchronicity of liver metastases. Low preoperative MPO in serum might identify patients at high risk of recurrence and death after resection of colorectal liver metastases.
Article
Multidisciplinary Sciences
Andriana Purnama, Kiki Lukman, Reno Rudiman, Dwi Prasetyo, Yoni Fuadah, Prapanca Nugraha, Valeska Siulinda Candrawinata
Summary: COX-2 is overexpressed in colorectal tumour tissue and is associated with lymph node invasion and liver metastasis in colorectal cancer patients. Further studies are needed to determine the prognostic significance of COX-2 expression in metastasis status for colorectal cancer patients.
Article
Medicine, Research & Experimental
Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu
Summary: The study found that Fusobacterium nucleatum (F. nucleatum) can promote migration and metastasis of colorectal cancer (CRC) cells by upregulating Matrix metalloproteinase 7 (MMP7), and F. nucleatum and MMP7 may serve as potential therapeutic targets for suppressing CRC progression and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
