Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Microbiology
Lu Han, Xu Shu, Jian Wang
Summary: This review summarizes the oxidative stress response triggered by Helicobacter pylori (HP) in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Medicine, Research & Experimental
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Summary: Stomach cancer is a leading cause of cancer death, primarily caused by Helicobacter pylori infection, which induces inflammation and DNA damage. 2-hydroxybenzylamine (2-HOBA), derived from buckwheat seeds, is effective in reducing gastritis, gastric dysplasia, and carcinogenesis caused by H. pylori infection in mice and gastric epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pragyesh Dixit, Swathi Shivaram Suratkal, Shrikant Babanrao Kokate, Debashish Chakraborty, Indrajit Poirah, Supriya Samal, Niranjan Rout, Shivaram P. Singh, Arup Sarkar, Asima Bhattacharyya
Summary: This study elucidates a novel mechanism of oxidative stress regulation by phosphorylated Siah2 in H. pylori-infected gastric epithelial cancer cells. Phosphorylation of Siah2 enhances the generation of reactive oxygen species (ROS) induced by H. pylori and leads to the degradation of the antioxidant protein GRP78. Surprisingly, cells expressing Siah2 with a phospho-null mutation have lower levels of cellular GRP78 but release more GRP78 and accumulate higher levels of ROS.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Microbiology
Ling Zhang, Ming Zhao, Xiangsheng Fu
Summary: Helicobacter pylori (H. pylori) infection is a common cause of gastric disease, but the increase in antibiotic resistance has made it challenging to eradicate. The stomach has a unique microecology that can have positive, negative, or neutral effects on microbial fitness and function. This article reviews the imbalance of gastric microecology and its relationship with H. pylori, as well as potential methods for modulating gastric microecology to facilitate H. pylori eradication, such as probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Infection with H. pylori triggers a robust cellular response in the host, potentially leading to gastric cancer. The regulation of cellular processes through ubiquitinylation mechanisms influences various pathologies including cancer, yet the exact impact of H. pylori on this process remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
