Journal
MOLECULAR BIOLOGY REPORTS
Volume 38, Issue 8, Pages 5261-5279Publisher
SPRINGER
DOI: 10.1007/s11033-011-0676-7
Keywords
Class 1 integron; Methicillin-resistance staphylococci (MRS); Antibiotic resistance; Mobile genetic element; SCCmec
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Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health [R01 AI69568-01A2]
- China Scholarship Council [2008615044]
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As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains one of the most prevalent pathogens that cause nosocomial infections throughout the world and has been recently labeled as a super bug in antibiotic resistance. Thus, surveillance and investigation on antibiotic resistance mechanisms involved in clinical MRS strains may raise urgent necessity and utmost significance. As a novel antibiotic resistance mechanism, class 1 integron has been identified as a primary source of antimicrobial resistance genes in Gram-negative organisms. However, most available studies on integrons had been limited within Gram-negative microbes, little is known for clinical Gram-positive bacteria. Based on series studies of systematic integrons investigation in hundreds of staphylococci strains during 2001-2006, this review concentrated on the latest development of class 1 integron in MRS isolates, including summary of prevalence and occurrence of class 1 integron, analysis of correlation between integron and antibiotic resistance, further demonstration of the role integrons play as antibiotic determinants, as well as origin and evolution of integron-associated gene cassettes during this study period.
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