Article
Environmental Sciences
Ke-Cheng Zhu, Hua-Yang Guo, Liang Guo, Bao-Suo Liu, Nan Zhang, Shi-Gui Jiang, Dian-Chang Zhang
Summary: This study investigated the sequence features, expression levels, and regulatory mechanism of TNF alpha in golden pompano. The results showed that NF-kappa B positively regulates the transcription of TNF alpha by interacting with the promoter region of ToTNF alpha.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Evolutionary Biology
Michelle M. Leger, Nuria Ros-Rocher, Sebastian R. Najle, Inaki Ruiz-Trillo
Summary: The Rel/NF-kappa B transcription factor family plays diverse roles in immunity, development, and differentiation in animals. New research suggests that these proteins originated earlier than previously thought, in the last common ancestor of animals and fungi. The proteins in the sister group to fungi also contain elements necessary for subcellular regulation of Rel/NF-kappa B, similar to those found in animals.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Tuoyang Li, Junyi Zhou, Yingming Jiang, Yandong Zhao, Jintuan Huang, Weiyao Li, Zhenze Huang, Zijian Chen, Xiaocheng Tang, Hao Chen, Zuli Yang
Summary: This study investigated the role of ADAMTS16 in gastric cancer and found that it promotes cell migration, invasion, and proliferation by targeting IFI27 through the NF-kappa B pathway. ADAMTS16 may serve as a potential biomarker for the progression and survival of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Medicine, Research & Experimental
Lihua Zhao, Lei Jin, Bin Yang
Summary: The study found that diosmetin suppressed Staphylococcus aureus-induced mastitis by attenuating inflammation and ferroptosis.
Article
Biochemistry & Molecular Biology
Liang Tian, Guangfan Liu, Ziqi Kang, Peishi Yan
Summary: The aim of this study was to evaluate the role of MARK4 in regulating oxidative stress and mitochondrial dysfunction in pig placental trophoblasts. The results showed that enhanced MARK4 contributed to increased oxidative stress and impaired mitochondrial function. Antioxidant treatment with vitamin E and activation of the AMPK signaling pathway were found to alleviate the negative effects of enhanced MARK4. The IKK alpha/NF-kappa B signal pathway was also implicated in MARK4 activated oxidative stress and mitochondrial dysfunction.
Article
Biology
Nicholas Sim, Yinghui Li
Summary: p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression. Chronic inflammation promotes glioma progression by activating NF-kappa B signalling, which promotes cancer cell invasion and angiogenesis. Non-canonical NF-kappa B activation directly regulates p52 at the ETS1 promoter, leading to its overexpression and impacting the genomic landscape of ETS1 in a glioma-specific manner.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Theresa Wolfram, Leonie M. Weidenbach, Johanna Adolf, Maria Schwarz, Patrick Schaedel, Andre Gollowitzer, Oliver Werz, Andreas Koeberle, Anna P. Kipp, Solveigh C. Koeberle
Summary: The study shows that selenium can regulate the redox signaling in macrophages, affecting the expression of selenoproteins and the production of lipid mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matthew Martin, Rasika Mundade, Antja-Voy Hartley, Guanglong Jiang, Jiamin Jin, Steven Sun, Ahmad Safa, George Sandusky, Yunlong Liu, Tao Lu
Summary: ARMC4 is identified as a novel negative regulator of NF-kappa B, and may serve as a potential therapeutic target in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Linwei Yang, Zi-Ang Wang, Ran Geng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: In this study, a protein called KLHDC2 was identified and investigated for its immune function in Pacific white shrimp. KLHDC2 was found to enhance the immune defense against Vibrio parahaemolyticus but inhibit that against white spot syndrome virus. It regulates the expression of immune effector genes and has a complex regulatory relationship with NF-kappa B family members.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Gen Chen, Ning An, Weijian Ye, Shuai Huang, Yunjie Chen, Zhicheng Hu, Enzhao Shen, Junjie Zhu, Wenjie Gong, Gaozan Tong, Yu Zhu, Lexuan Fang, Chunyuan Cai, Xiaokun Li, Kwonseop Kim, Litai Jin, Jian Xiao, Weitao Cong
Summary: The study demonstrates that bFGF plays a key regulatory role between S-nitrosylation homeostasis and inflammation, alleviating endothelial dysfunction and angiogenic defects in diabetes. Under conditions of hyperglycemia and hyperlipidemia, bFGF was found to suppress inflammation via the S-nitrosylation pathway.
Article
Biochemistry & Molecular Biology
Won-Il Choi, Jae-Hyun Yoon, Seo-Hyun Choi, Bu-Nam Jeon, Hail Kim, Man-Wook Hur
Summary: The study revealed that Zbtb7c protein represses the expression of the SIRT1 gene by interacting with the p53 protein. Overexpression of Zbtb7c affects the expression of genes involved in lipid metabolism, potentially providing a molecular target for the treatment of diabetes, obesity, and longevity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)