Journal
MOLECULAR BIOLOGY REPORTS
Volume 38, Issue 6, Pages 3821-3828Publisher
SPRINGER
DOI: 10.1007/s11033-010-0497-0
Keywords
Statins; Angiogenesis; Myocardial infarction; Atherosclerosis
Categories
Funding
- Natural Science Foundation of China [30873350]
- City Health Administration Project of Shanghai [2009006]
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Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study ischemic myocardium and atherosclerosis together to mimic clinical scenario. We demonstrated that simvastatin has the effect of pro-angiogenesis and further improve cardiac function in ischemic myocardium, as well as the effect of anti-angiogenesis to improve atherosclerosis in aorta vessels.
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