Journal
MOLECULAR BIOLOGY REPORTS
Volume 36, Issue 7, Pages 1943-1950Publisher
SPRINGER
DOI: 10.1007/s11033-008-9403-4
Keywords
Anthropology; Ethnic groups; HLA polymorphism; Iran
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Funding
- Shiraz University of Medical Sciences
- Iranian Molecular Medicine Network
- Shiraz Institute of Cancer Research
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Highly polymorphic human leukocyte antigen (HLA) genes are considered as useful markers by molecular anthropologists to determine genetic relationship among populations. This review summarizes the results of molecular analyses of HLA class II gene polymorphism in 816 DNA samples from 11 Iranian ethnic groups. The genetic relationship of Iranians to Asians and Europeans has also been reported here. The results of this study revealed a close genetic relationship among Iranian subpopulations which were well separated from other Asian and European populations, however, a genetic similarity was observed among Iranians, Macedonians, Greeks, and Italians.
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