Article
Oncology
Rui Shi, Zirong Liu
Summary: RPL15 plays crucial roles in the progression and metastasis of hepatocellular carcinoma (HCC), serving as a promising candidate for targeted therapies.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jihyun Lee, Jongdoo Kim, Eun Mi Kim, Ukjin Kim, A-Ram Kang, Jong Kuk Park, Hong-Duck Um
Summary: In this study, it was found that p21 acts as a negative regulator of p53 stability, reducing the cellular levels of p53 protein and promoting its degradation. Additionally, p21 promotes the interaction between p53 and Wip1, and forms a trimeric complex with Wip1. The p21/p53 complex is more efficient in facilitating the binding of p53 to Wip1 and Mdm2, suggesting that p21 may be a potential target to restore p53 activity in cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Abir Zebian, Maya El-Dor, Abdullah Shaito, Frederic Mazurier, Hamid Reza Rezvani, Kazem Zibara
Summary: XPC plays a crucial role in DNA damage recognition and repair, as well as DNA damage response and cell fate decisions. Its interactions with other proteins can influence cell apoptosis, senescence, or tumorigenesis. Understanding the status of XPC is important for successful cancer treatment and patient survival.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Review
Cell Biology
Che-Pei Kung, Jason D. Weber
Summary: The relationship between P53, MDM2, and ARF plays a crucial role in tumor suppression mechanisms, but our understanding of this relationship needs to be updated in order to develop more effective cancer treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Wuyi Wang, Jinlai Wei, Hairong Zhang, Xiangru Zheng, He Zhou, Yajun Luo, Jianguo Yang, Qican Deng, Siqi Huang, Zhongxue Fu
Summary: PRDX2, a member of the peroxiredoxin family, has been found to be upregulated in colorectal cancer and promotes cancer cell proliferation. The oncogenic property of PRDX2 is attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jongdoo Kim, Jihyun Lee, Ukjin Kim, Jong-Kuk Park, Hong-Duck Um
Summary: The study demonstrated that Slug promotes the degradation of p53 and p21 by inducing the expression of Mdm2, indicating a complex regulatory mechanism involving these proteins in cancer cells.
Article
Biochemistry & Molecular Biology
Hua Yang, Yanyan Liu, Jingyi Yang, Qing Zhang, Haoran Wang, Yu Chen, Keshu Zhou
Summary: This study revealed the biological roles of deubiquitinase USP25 in the tumorigenesis of DLBCL. USP25 was found to be frequently upregulated in DLBCL and associated with poor prognosis. Inhibition of USP25 suppressed DLBCL growth and migration, while increasing apoptosis. Mechanistically, USP25 stabilized MDM2 and subsequently decreased p53 expression, promoting DLBCL progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Pingzhao Zhang, Kun Gao, Liang Zhang, Huiru Sun, Xiaying Zhao, Yajuan Liu, Zeheng Lv, Qing Shi, Yingji Chen, Dongyue Jiao, Yao Li, Wei Gu, Chenji Wang
Summary: This study demonstrates the important role of CRL2-KLHDC3 E3 ubiquitin ligase complex in regulating the stability of p14(ARF) protein, with KLHDC3 promoting ubiquitin-proteasomal degradation of p14(ARF) to suppress ferroptosis and support tumor growth. The findings suggest that overexpression of KLHDC3 likely contributes to cancer progression by suppressing the p14(ARF)-NRF2-SLC7A11 regulatory pathway.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Young-Seuk Bae, Sang Hyun Kim, Seung-Soon Im, Ji Hae Seo, Kyoung-Jin Min, Taeg Kyu Kwon
Summary: Inhibition of cathepsin K enhances oxaliplatin-induced apoptosis by increasing OTUB1 phosphorylation, promoting p53 stabilization, and upregulating Bax expression, leading to decreased tumor size. There is a strong correlation between phosphorylation of OTUB1(Ser16) and p53/Bax expression in human renal clear cell carcinoma tissues.
Article
Biochemistry & Molecular Biology
Timothy J. Humpton, Holly Hall, Christos Kiourtis, Colin Nixon, William Clark, Ann Hedley, Robin Shaw, Thomas G. Bird, Karen Blyth, Karen H. Vousden
Summary: p53 is a crucial transcription factor that plays a role as a tumor suppressor and regulates cell elimination, survival, and repair in response to stress. Studies have shown that p53 is involved in liver repair from CCl4-induced damage and limits the development of HCC, partly through the activation of detoxification cytochrome P450 CYP2A5/CYP2A6.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Naga Padma Lakshmi Ch, Ananthi Sivagnanam, Sebastian Raja, Sundarasamy Mahalingam
Summary: RASSF10 inhibits Cdk1/cyclin-B complex formation to induce mitotic arrest and inhibit cell proliferation, while promoting nuclear accumulation of GADD45a. Nucleophosmin (NPM) is a novel functional target of RASSF10, critical for RASSF10-mediated G2/M phase arrest. Knockdown of NPM or GADD45a impairs RASSF10-mediated cell cycle regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Oncology
Chunwei W. Lai, Cindy Xie, Jean-Pierre Raufman, Guofeng Xie
Summary: This review examines the regulatory mechanisms involved in p53 signaling pathway and their evasion by p53 mutants in colorectal cancer. It also discusses potential therapeutic strategies for targeting p53 mutant-bearing tumors.
Article
Medicine, Research & Experimental
Liang Chen, Wencheng Li, Zhiqin Li, Yarong Song, Jun Zhao, Zhaohui Chen, Gallina Kazobinka, Lulu Li, Yifei Xing, Teng Hou
Summary: The study identified circNUDT21 as an oncogenic circular RNA that promotes bladder cancer progression through the miR-16-1-3p/MDM2/p53 axis. This suggests circNUDT21 as a potential therapeutic target for bladder cancer. CircNUDT21 regulates the proliferative and invasive abilities of bladder cancer cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Maryam Rasouli, Sara Khakshournia, Omid Vakili, Sanaz Dastghaib, Atefeh Seghatoleslam, Sayed Mohammad Shafiee
Summary: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. UBE2Q1, a newly identified ubiquitin-conjugating enzyme, is significantly expressed in colorectal tumors. The study suggests that UBE2Q1 may contribute to CRC progression by modulating the levels of p53 protein. Experimental results show that transfection of UBE2Q1 leads to a significant decrease in p53 protein levels in SW480 cells, while the change in p53 protein levels is not significant in LS180 cells. This indicates that UBE2Q1 may promote CRC progression by interacting with and degrading p53 protein.
Review
Cell Biology
Hua-Chuan Zheng, Hang Xue, Cong-Yu Zhang
Summary: The REG4 gene plays a role in infection and inflammation by promoting macrophage polarization and killing inflammatory Escherichia coli. It is closely linked to tumorigenesis and is overexpressed in various cancers, contributing to aggressive behaviors and poor prognosis. REG4 can aggravate cellular phenotypes involved in tumorigenesis, migration, invasion, and resistance to chemotherapy and radiation. It also promotes the formation of colon stem cells by inhibiting Notch and activating Wnt. REG4 could serve as a biomarker and therapeutic target for cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Fen Zhou, Dengliang Huang, Yong Li, Guanghui Hu, Hai Rao, Quqin Lu, Shiwen Luo, Yao Wang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2017)
Article
Multidisciplinary Sciences
Haili Cheng, Xin Bao, Xin Gan, Shiwen Luo, Hai Rao
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Guohui Hu, Lizette Rios, Zhengwei Yan, Angela M. Jasper, Dezzarae Luera, Shiwen Luo, Hai Rao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Karthigayan Shanmugasundaram, Peng Shao, Han Chen, Bismarck Campos, Stanton F. McHardy, Tuoping Luo, Hai Rao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Zhengwei Yan, Karthigayan Shanmugasundaram, Dongwen Ma, Jiayu Luo, Shiwen Luo, Hai Rao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs
Article
Cell Biology
Zhengwei Yan, Minzhang Cheng, Guohui Hu, Yao Wang, Shaopeng Zeng, Aidi Huang, Linlin Xu, Yuan Liu, Chao Shi, Libin Deng, Quqin Lu, Hai Rao, Hua Lu, Ye-Guang Chen, Shiwen Luo
Summary: The study identified SuFu Negating Protein 1 (SNEP1) as a novel target in the Hedgehog (Hh) signaling pathway, promoting colorectal cancer cell proliferation and tumor growth, as well as reducing sensitivity to anti-Hh inhibitors. SNEP1 destabilizes SuFu to regulate Hh signaling, playing a critical role in tumor growth and anti-Hh resistance.
CELL DEATH & DISEASE
(2021)
Review
Genetics & Heredity
Jialing Liu, Jingru Lian, Yafei Chen, Xin Zhao, ChangZheng Du, Yang Xu, Hailiang Hu, Hai Rao, Xin Hong
Summary: Late-stage cancer metastasis is incurable in the clinic and is the leading cause of death in patients. Circulating tumor cells (CTCs), considered to be metastatic precursors shed from primary tumors, present challenges in isolation and characterization. Despite these difficulties, recent advancements in CTC isolation and culture techniques show promise for potential use as non-invasive biomarkers in predicting therapeutic response.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Jun Che, Xin Hong, Hai Rao
Summary: Lesions in DNA that escape repair can block DNA replication, which is handled during the S/G2 phases by damage tolerance mechanisms such as TLS and TS. The ubiquitylation of PCNA plays a critical role in determining the choice between TLS and TS pathways, with competition between the two pathways being influenced by the type of DNA lesion.
Article
Oncology
Jianchao Zhang, Xiaokai Fan, Lijuan Liao, Yan Zhu, Xiaochun Wan, Hai Rao, Liang Chen
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Hai Rao, Jun Che, Changhui Yin, Yunfan Zhou, Yifang Ma, Ruilin Tian
Summary: While the process of publishing a scientific paper has become simpler, it is increasingly difficult to publish in high profile journals. There is a divide emerging between scientist-run journals and professionally-run high profile journals. The current standards of high profile journals may hinder the scientific discovery process.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Green & Sustainable Science & Technology
Haonan Cui, Haili Cheng, Tianyong Huang, Feihua Yang, Haoxiang Lan, Jvlun Li
Summary: This study investigated the properties of a ternary cementitious composite containing blast furnace's slag, gold tailings, and red mud using activators NaOH, KOH, and Na2SiO3. The findings demonstrated that the use of Na2SiO3 as an activator resulted in the best macroscopic mechanical properties. Toxicity tests also showed that the ternary composite was environmentally friendly.
Article
Oncology
Jia Shao, Linlin Xu, Limin Chen, Quqin Lu, Xinsheng Xie, Wei Shi, Huanting Xiong, Chao Shi, Xuan Huang, Jinhong Mei, Hai Rao, Hua Lu, Nonghua Lu, Shiwen Luo
Article
Cell Biology
Hong Peng, Jiao Yang, Guangyi Li, Qing You, Wen Han, Tianrang Li, Daming Gao, Xiaoduo Xie, Byung-Hoon Lee, Juan Du, Jian Hou, Tao Zhang, Hai Rao, Ying Huang, Qinrun Li, Rong Zeng, Lijian Hui, Hongyan Wang, Qin Xia, Xuemin Zhang, Yongning He, Masaaki Komatsu, Ivan Dikic, Daniel Finley, Ronggui Hu