The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

(2012) Erik S. Welf et al.   JOURNAL OF CELL BIOLOGY

FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

(2012) K. Kunida et al.   JOURNAL OF CELL SCIENCE

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

(2009) M. C. Weiger et al.   JOURNAL OF CELL SCIENCE

Robust Neuronal Symmetry Breaking by Ras-Triggered Local Positive Feedback

(2008) Marc Fivaz et al.   CURRENT BIOLOGY

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

(2008) Yoichiro Kamimura et al.   CURRENT BIOLOGY

On the spontaneous emergence of cell polarity

(2008) Steven J. Altschuler et al.   NATURE

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One