Article
Plant Sciences
Qi Chen, Kai Xu, Yan Xu, Dehua Ji, Changsheng Chen, Chaotian Xie, Wenlei Wang
Summary: This study analyzed the function of Na+/K+-ATPase in the response of Neoporphyra haitanensis to salt stress and found that it played a crucial role in maintaining the K+/Na+ homeostasis in the algae. The inhibitor ouabain caused Na+ accumulation and K+ leakage in the cells, disrupting the K+/Na+ balance and leading to decreased photosynthesis and oxidative damage in the algae.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wen-Qiang Lai, Hou-Fu Xia, Gao-Hong Chen, Xiao-Le Wang, Jie-Gang Yang, Lian-Zhi Wu, Yi-Fang Zhao, Yu-Lin Jia, Gang Chen
Summary: This study aims to clarify the detailed changes of small extracellular vesicles (sEVs) in venous malformations (VMs). The size of sEVs derived from both VM lesion tissues and cell model was significantly increased. Downregulated VPS4B in endothelial cells, resulted from abnormally activated AKT signaling, contributed to the increased size of sEVs in VMs.
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Junping Feng, Wenyu Ma, Zongbin Ma, Zhongying Ren, Yang Zhou, Junjie Zhao, Wei Li, Wei Liu
Summary: GhNHX3D, a vacuolar sodium/proton antiporter from upland cotton, can enhance salt tolerance by adjusting the cellular balance of Na+ and K+ ions. Its function was confirmed through transient expression and VIGS experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Miyer Patino-Ruiz, Constanta Ganea, Octavian Calinescu
Summary: Na+/H+ exchangers play a crucial role in maintaining Na+ and pH homeostasis in all organisms, with human Na+/H+ exchangers being of high medical interest. While structures have been solved for several CPA and Mrp members, IT members remain unstudied. Understanding of shared working principles among Na+/H+ exchangers from different families has been facilitated by recent studies on CPA exchangers and diverse functional information.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Katsuharu Tsuchida, Hitomi Hirose, Sachiyo Ozawa, Haruka Ishida, Tomomi Iwatani, Uraka Matsumoto
Summary: Monensin shortened action potential duration and reduced plateau phase amplitude in ventricular myocytes primarily by decreasing L-type calcium current, activating reverse mode of Na-Ca exchange current, and increasing Na-K pump current, and secondarily by decreasing sodium current. Inward rectifying K current and delayed outward K current were minimally affected by monensin-induced changes. Elevation of intracellular Na can have multiple influences on electrophysiological phenomena in cardiac myocytes.
Article
Physiology
Sian-Tai Liu, Jiun-Lin Horng, Li-Yih Lin
Summary: This study investigates the subcellular localization and function of NHE2 in ionocytes of seawater fishes, showing its crucial role in acid-base regulation and salt secretion.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou, Xiaolong Tang
Summary: IGF-1R promotes the proliferation, migration, and anti-apoptosis of HCC cells through the PI3K / Akt and RAS / Raf / ERK signaling pathways, leading to sorafenib resistance. Knockdown of IGF-1R reduces proliferation and migration, and enhances sorafenib-induced apoptosis in HCC cells. In vivo experiments demonstrate that IGF-1R knockdown inhibits the growth of SK-Hep1 xenografts, indicating a role of IGF-1R in regulating HCC survival and cell growth. Intervention in IGF-1R expression may enhance the inhibitory effect of sorafenib on HCC.
Article
Gastroenterology & Hepatology
Wen-Zhi Qu, Luan Wang, Juan-Juan Chen, Yang Wang
Summary: This study aims to detect the expression of RKIP, P-ERK, and P-MEK proteins in GIST and analyze their relationship with clinicopathological characteristics and prognosis. A new prognosis evaluation model using RKIP and P-ERK is established and its efficacy is evaluated.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Son H. Pham, Sofia I. Vuorinen, K. M. Taufiqul Arif, Lyn R. Griffiths, Rachel K. Okolicsanyi, Larisa M. Haupt
Summary: Despite the use of anti-HER2 therapy, HER2-positive breast cancers remain a challenge in treatment interventions. This study investigated the role of HSPGs in HER2-positive human breast cancer cell lines and found that the HSPG syndecan-4 (SDC4) core protein significantly regulates cell proliferation. In addition, changes in CK19/AKT signaling were identified as mediators of HER2-positive breast cancer cell proliferation. This study highlights the potential of targeting the HSPGs/CK19-AKT axis to inhibit the proliferation of HER2-positive breast cancer cells.
Article
Biotechnology & Applied Microbiology
Aasma Parveen, Sunny Ahmar, Muhammad Kamran, Zaffar Malik, Ahmad Ali, Muhammad Riaz, Ghulam Hassan Abbasi, Mumtaz Khan, Anabat Bin Sohail, Muhammad Rizwan, Sobia Afzal, Shafaqat Ali
Summary: The study demonstrated that root-zone application of ABA improved salt tolerance in wheat seedlings by reducing salt-induced damage, promoting growth and development, and regulating antioxidant responses.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Plant Sciences
M. Nasir Khan, Soumya Mukherjee, Asma A. Al-Huqail, Riyadh A. Basahi, Hayssam M. Ali, Bander M. A. Al-Munqedhi, Manzer H. Siddiqui, Hazem M. Kalaji
Summary: The study reveals that under NaCl stress, application of 5 mM K+ in conjunction with endogenous H2S positively regulates the Na+/H+ antiport system, facilitating K+ influx and Na+ efflux, resulting in the maintenance of a higher K+/Na+ ratio.
Article
Pathology
Yoshiyasu Fukusumi, Hidenori Yasuda, Ying Zhang, Hiroshi Kawachi
Summary: This study investigated the role of ephrin-B1 and its associated molecules in the slit diaphragm of kidney glomerular podocytes. It was found that the interactions between ephrin-B1, NHERF2, and other molecules formed a critical signaling axis in podocytes, with phosphorylation and dephosphorylation playing key regulatory roles.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Jeeho Kim, Young Jin Jeon, Sung-Chul Lim, Joohyun Ryu, Jung-Hee Lee, In-Youb Chang, Ho Jin You
Summary: Ephexin1 is highly expressed in patient tissues of colorectal cancer (CRC) and lung cancer (LC), and plays a critical role in promoting tumorigenesis through the Ras-mediated signaling pathway. Phosphorylated Ephexin1 at Ser16 and Ser18 (pSer16/18) may serve as an effective therapeutic target for CRC and LC as it interacts with oncogenic K-Ras to promote downstream MAPK signaling.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yinhong Zhu, Xiaoran Zhang, Shujuan Xie, Weijia Bao, Jingrou Chen, Qili Wu, Xiaorong Lai, Longshan Liu, Shiqiu Xiong, Yanwen Peng
Summary: This study reveals the crucial role of mitochondrial oxidative phosphorylation (OXPHOS) in regulating interleukin (IL)-10 expression in regulatory B cells (Bregs). Inhibition of OXPHOS reduces IL-10 expression in B cells and impairs the therapeutic effects of Bregs in colitis. The study also demonstrates a strong correlation between mitochondrial OXPHOS and Breg phenotype/function and suggests OXPHOS as a potential therapeutic target for autoimmune diseases.
Article
Biochemistry & Molecular Biology
Yanmei Yang, Bin Wang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Cell Biology
Yanmei Yang, Hong Lei, Ya-wei Qiang, Bin Wang
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Biochemistry & Molecular Biology
Tonio Pera, Deepak A. Deshpande, Michael Ippolito, Bin Wang, Adelina Gavrila, James V. Michael, Ajay P. Nayak, Eric Tompkins, Eleni Farrell, Wesley K. Kroeze, Bryan L. Roth, Reynold A. Panettieri, Jeffrey L. Benovic, Steven S. An, Nickolai O. Dulin, Raymond B. Penn
Article
Chemistry, Medicinal
Bin Wang, Min-Zhu Chen
ARCHIVES OF PHARMACAL RESEARCH
(2014)
Article
Endocrinology & Metabolism
Bin Wang, Yanmei Yang, Li Liu, Harry C. Blair, Peter A. Friedman
Article
Biochemistry & Molecular Biology
Juan A. Ardura, Bin Wang, Simon C. Watkins, Jean-Pierre Vilardaga, Peter A. Friedman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Bin Wang, Chris K. Means, Yanmei Yang, Tatyana Mamonova, Alessandro Bisello, Daniel L. Altschuler, John D. Scott, Peter A. Friedman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Gyun Jee Song, Kristen L. Leslie, Stacey Barrick, Tatyana Mamonova, Jeremy M. Fitzpatrick, Kenneth W. Drombosky, Noah Peyser, Bin Wang, Maria Pellegrini, Philip M. Bauer, Peter A. Friedman, Dale F. Mierke, Alessandro Bisello
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Endocrinology & Metabolism
Veronica Alonso, Juan A. Ardura, Bin Wang, W. Bruce Sneddon, Peter A. Friedman
JOURNAL OF BONE AND MINERAL RESEARCH
(2011)
Review
Endocrinology & Metabolism
Yanmei Yang, Bin Wang
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yanmei Yang, Hong Lei, Bin Wang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Tonio Pera, Eric Tompkins, Michael Katz, Bin Wang, Deepak A. Deshpande, Edward J. Weinman, Raymond B. Penn
Article
Biochemistry & Molecular Biology
Amit Gaur, Jessica Lipponen, Yanmei Yang, Roger S. Armen, Bin Wang
Summary: This study investigates the impact of oxidation on the biological function of human parathyroid hormone (PTH). The results show that oxidation of methionine residues in PTH leads to a significant reduction in biological activity. Furthermore, the conversion from a hydrophobic residue to a hydrophilic residue disrupts the hydrophobic interaction between PTH and its receptor, resulting in the loss of biological function.
Article
Multidisciplinary Sciences
Bryce Z. Stewart, Tatyana Mamonova, W. Bruce Sneddon, Airah Javorsky, Yanmei Yang, Bin Wang, Thomas D. Nolin, Patrick O. Humbert, Peter A. Friedman, Marc Kvansakul
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Yanmei Yang, Wei-Ju Tseng, Bin Wang
Summary: ABL is a PTH-related peptide (1-34) analog used for the treatment of osteoporosis. It has a potent anabolic effect and causes less hypercalcemia. However, the mechanism by which ABL maintains blood calcium stability is unclear.