Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 31, Issue 2, Pages 194-204Publisher
ELSEVIER
DOI: 10.1016/j.mam.2010.02.004
Keywords
Melanoma; Therapy; Molecular
Funding
- American Cancer Society
- National Institutes of Health
- Massachusetts General Hospital
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Metastatic melanoma is a highly lethal cancer that has historically been refractory to all tested pharmacological agents. An understanding of the mechanisms responsible for its oncogenesis is critical for developing successful therapies. An enormous amount of data generated over the last few decades have revealed important biological insights into melanoma initiation, progression and maintenance, which bring new directions and approaches to treatment of this devastating skin cancer. (C) 2010 Elsevier Ltd. All rights reserved.
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