Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 44, Issue 3, Pages 233-245Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2010.03.010
Keywords
Odorant receptor; Olfactory sensory neuron; Olfactory epithelium; Axonal projection; Neuropilin-2; Olfactory bulb; Olfactory map
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Japan Science and Technology Corporation
- Novartis Foundation
- Terumo Foundation, Japan
- Kao Foundation for Arts and Sciences, Japan
- Uehara Memorial Foundation, Japan
- Naito Foundation, Japan
- Sumitomo-, Life Science- and Mochida Memorial-Foundations, Japan
- Grants-in-Aid for Scientific Research [22700341] Funding Source: KAKEN
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Recent evidence shows that olfactory sensory neurons expressing a given odorant receptor (OR) are not necessarily confined to one of four zones, rather arranged in an overlapping manner in the olfactory epithelium (OE). In this study, in situ hybridization of OE sections with the OR probes indicated that the OR genes, the mRNAs of which were detected in an array of glomeruli on olfactory bulb (OB) along the anterodorsal/posteroventral (AD/PV) axis, are expressed in subareal zones within the most ventral zone, zone 4, along the dorsomedial/ventrolateral (DM/VL) axis. We also found that Neuropilin-2 (Nrp2) is expressed in a DM-low to VL-high gradient within zone 4 of OE. Furthermore, in Nrp2 mutant mice, we observed multiple glomeruli for zone 4 ORs in OB. These results suggest that the graded expression of Nrp2 in OE is required for the proper targeting of ventral glomeruli along the AD/PV axis in OB. (C) 2010 Elsevier Inc. All rights reserved.
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