Article
Plant Sciences
Yue Lu, Qing Bu, Mingli Chuan, Xiaoyun Cui, Yu Zhao, Dao-Xiu Zhou
Summary: Chromatin modifications play a crucial role in shaping the epigenome and regulating gene expression during plant development and adaptation to environmental changes. The activities of chromatin modification enzymes are influenced by cellular metabolites, such as S-adenosyl-methionine, acetyl-CoA, alpha-ketoglutarate, and NAD(+). On the other hand, changes in the plant epigenome and activity of epigenetic regulators can impact cellular metabolism through regulation of metabolic enzymes. This review highlights recent advances in understanding the metabolic control of plant chromatin regulators and epigenomes, which contribute to plant adaptation to environmental stresses.
Article
Endocrinology & Metabolism
Amanda L. Morin, Phyo W. Win, Angela Z. Lin, Christina A. Castellani
Summary: Bidirectional crosstalk between the nuclear and mitochondrial genomes is crucial for cell functioning. Mitochondrial DNA copy number and heteroplasmy can influence mitochondrial function, nuclear genome, and contribute to overall health and disease. Mitochondria act as environmental biosensors, conveying essential information about cell state to the nuclear genome. Cellular communication between mitochondrial variation and nuclear epigenome can occur through modifications of metabolites and intermediates, affecting epigenetic modifications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Deimante Zukauskaite, Aida Vitkeviciene, Akvile Zlibinaite, Raminta Bausyte, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The aim of this study was to analyze the changes in epigenetic modulators, histone modifications, and DNA methylation during induced human endometrial stromal cells (ESC) in vitro decidualization. The results revealed that HDAC2 and subunits of PRC2 were down-regulated while the global level of H4hyperAc and H3K27me3 increased during ESC decidualization. Specific gene promoters' histone acetylation level also increased during the induced ESC decidualization, indicating the importance of epigenetic regulation in endometrial decidualization.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yusuke Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai
Summary: The study developed a chemical catalyst that can achieve histone acetylation in living cells without genetic manipulation, offering a new tool for studying epigenetic regulation. This chemical method competes with and suppresses normal chromatin function markers, providing insights into epigenetic mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Lu Xiong, Wenguan Zhou, Paloma Mas
Summary: The circadian clock and light signaling pathways are closely interconnected, and chromatin remodeling plays a crucial role in regulating transcription timing and light-dependent responses.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Oncology
Rohini Sharma, Mark P. Lythgoe, Bhavandeep Slaich, Nishil Patel
Summary: This review summarizes the existing knowledge on epigenetic changes in neuroendocrine neoplasms, emphasizing their potential contributions to pathogenesis and oncogenesis. It focuses on well-differentiated neuroendocrine tumors, which are the majority of NENs, highlighting both similarities and differences within GEP-NETs subtypes and their comparison to other types of cancers. Additionally, it explores how epigenetic understanding can be utilized in developing novel treatment approaches and discusses strategies to optimize research and development in GEP-NENs.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Poddar
Summary: Epigenetics has opened a new dimension in exploring unanswered questions in genetics, particularly in neurodegenerative diseases like Alzheimer's and cancers. The alterations in DNA methylation levels, histone acetylation, and methylation play a significant role in conditions such as Alzheimer's disease. Studying the interplay between the mTOR regulatory pathway and epigenetic machinery may lead to early diagnosis and novel therapeutic strategies for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Genetics & Heredity
Merrick S. Fallah, Dora Szarics, Clara M. Robson, James H. Eubanks
Summary: Epigenetic processes play a critical role in regulating gene expression patterns in neurodevelopment, including the dynamic network of post-translational histone modifications. Mutations in histone-modifying enzymes can disrupt this system and lead to developmental consequences. This review examines neurodevelopmental conditions associated with histone methylation and acetylation, discussing clinical phenotypes, genetic bases, and model systems for studying pathological mechanisms.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Oncology
Irfete S. Fetahu, Sabine Taschner-Mandl
Summary: Neuroblastoma is a common solid tumor in infants, with genetic and epigenetic alterations playing a key role in its pathogenesis. Aberrant DNA methylation, disrupted histone modification patterns, and abnormal expression of non-coding RNAs are major epigenetic changes associated with NB.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Bibiana Torok, Csilla Lea Fazekas, Adrienn Szabo, Dora Zelena
Summary: Vasopressin, acting through V2, V1a, and V1b receptors, regulates kidney water resorption, blood pressure, stress-axis, social behavior, and memory. Its implication in depression and schizophrenia may involve epigenetic changes such as DNA methylation, histone modification, and micro RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Song, Julia A. VanBuskirk, Shannath L. Merbs
Summary: This study reveals an important role of epigenetic regulation in controlling opsin expression, and demonstrates this through experiments using epigenetic modifiers in cell cultures and mouse retinal explants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Obstetrics & Gynecology
Shenghui Huang, Fengyi Xiao, Sun-Wei Guo, Tingting Zhang
Summary: The compound Tetramethylpyrazine (TMP) has shown promise in slowing down the progression of endometriosis by inhibiting epithelial-mesenchymal transition, fibroblast-to-myofibroblast transdifferentiation, and fibrogenesis. In vitro experiments and a mouse model have demonstrated that TMP can significantly reduce lesion weight, fibrosis, and improve hyperalgesia associated with endometriosis.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study investigated the role of glycolysis in endometrial repair and heavy menstrual bleeding (HMB). Through mouse experiments and analysis of human endometrial samples, it was found that glycolysis plays an important role in endometrial repair, and its suppression delays the repair process and increases menstrual blood loss. Additionally, glycolysis suppression affects the proliferative and migratory capability of endometrial cells.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, General & Internal
Sun-Wei Guo
Summary: Adenomyosis is a common gynecological disease with unclear causes and mechanisms. Bleeding and tissue repair play a crucial role in its progression, with platelets leading the tissue repair process. This repeated tissue injury and repair can lead to fibrosis and various complications, such as heavy menstrual bleeding and an enlarged uterus. This review focuses on the role of platelets in the pathogenesis, progression, and complications of adenomyosis, and discusses the therapeutic implications. The concept of repeated tissue injury and repair provides a framework to better understand the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sun-Wei Guo, Giuseppe Benagiano, Marc Bazot
Summary: Adenomyosis is a complicated gynecological disease that is poorly understood. The diagnosis used to rely solely on histology after hysterectomy, but now imaging techniques like transvaginal ultrasound and MRI are increasingly used. However, the lack of a consensus on a classification system makes it difficult to relate imaging findings with disease severity or histopathological features, which hampers patient and clinician communication and comparative studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Sun-Wei Guo
Summary: Currently, hormonal drugs are the main treatment for endometriosis or adenomyosis, but their lack of innovation and failure to target specific areas is concerning. The failure to understand the natural history of the ectopic endometrium has led to many unsuccessful nonhormonal drug research projects. This review aims to explore new concepts in the progression of ectopic endometrium and provide insights for better therapeutic options.
FERTILITY AND STERILITY
(2023)
Editorial Material
Obstetrics & Gynecology
Michel Canis, Sun-Wei Guo
Summary: Endometriosis-associated pain can be managed through either surgery or hormonal therapy, with the final decision dependent on efficacy, complications, recurrence risk, and patient preferences. However, choosing the right treatment involves weighing irrational fears against scientific evidence. Pros and cons of both treatment options should be thoroughly discussed with patients, considering the known irrationality of human beings.
HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: Practically unknown outside of China, the endometrial determinism theory proposes a causal and phylogenetic relationship between endometrial aberrations and endometriosis. However, all available evidence of endometrial defect is post hoc and may be secondary to induced endometriosis. While endometriosis is likely a consequence of retrograde menstruation, the case for molecular aberrations as a sole or necessary determinant remains unproven. Root treatment is currently a far-fetched ambition.
Review
Biochemistry & Molecular Biology
Marwan Habiba, Giuseppe Benagiano, Sun-Wei Guo
Summary: Due to the complex nature of endometriosis and adenomyosis, the understanding of their pathogenesis remains unclear. A tissue injury and repair theory suggests that both diseases originate from the same abnormalities within the uterus, but this theory has faced criticism for its lack of confirmatory evidence and epidemiological support. The theory also fails to explain why only a small percentage of women develop these conditions. Further research and evidence are necessary to validate this theory.
Review
Biochemistry & Molecular Biology
Giuseppe Benagiano, Salvatore Mancuso, Sun-Wei Guo, Gian Carlo Di Renzo
Summary: This article highlights the significant number of early embryo losses during the pre-implantation period and the importance of the maternal-embryonic dialogue in the formation of placenta and completion of pregnancy. Several factors and molecules have been identified to play a role in this process, including Chorionic Gonadotrophin, Early Pregnancy Factor, Pre-Implantation Factor, and Embryo-Derived Platelet-activating Factor. The implantation process is guided by signals from various types of cells in the decidualized endometrium, and immune cells also play a role. The distinction between the first two weeks after fertilization and the rest of gestation is proposed, with the former period being named gestation and the latter period being named pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xishi Liu, Ding Ding, Minhong Shen, Dingmin Yan, Sun-Wei Guo
Summary: This study investigated the association between anogenital distance (AGD) and adenomyosis, endometriosis, and uterine leiomyomas (UL). The results showed that women with ovarian endometrioma (OE) and adenomyosis had significantly shorter AGD from the posterior fourchette to the center of the anus (AGDAF), but not from the anterior clitoral surface or the tip of the clitoris. The findings suggest that reduced prenatal exposure to androgens may increase the risk of developing endometriosis and adenomyosis, but other factors may also contribute to the pathogenesis of these conditions.
Article
Obstetrics & Gynecology
Tasuku Harada, Fuminori Taniguchi, Sun-Wei Guo, Young Min Choi, Kutay Omer Biberoglu, Shaw-Jenq Sean Tsai, Saeed Alborzi, Moamar Al-Jefout, Amphan Chalermchokcharoenkit, Angela G. Sison-Aguilar, Yoke-Fai Fong, Hemantha Senanayake, Alexander Popov, Andon Hestiantoro, Yuval Kaufman
Summary: This is the first guideline for adenomyosis from the Asian Society of Endometriosis and Adenomyosis.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: This study aimed to screen Zn2+-dependent histone deacetylase 1-11 (HDAC) in endometriotic cells and evaluate their expression in ovarian endometrioma (OE) and deep endometriosis (DE) lesions. The therapeutic potential of HDAC8 inhibition was also assessed in mice.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: The study evaluated the staining changes of Class I HDACs and Hdac6 in serially harvested lesion samples in mice with induced endometriosis. The results showed a progressive increase in staining of Hdac1, Hdac8, and Hdac6 during the course of lesional progression, while Hdac2 staining gradually decreased and Hdac3 staining was consistently reduced. Hdac8 activation accelerated the progression and fibrogenesis of endometriotic lesions, while inhibition of Hdac8 or Hdac6 hindered lesional progression and fibrogenesis, especially Hdac8 inhibition. Further investigation of epigenetic aberrations of endometriosis and HDACs is warranted.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study explores the role of histone deacetylase 3 (HDAC3) in adenomyosis-associated heavy menstrual bleeding (HMB). The researchers found that reduced expression of HDAC3 is associated with HMB in women with adenomyosis. Higher stiffness and fibrosis in the adenomyotic lesions and neighboring endometrial-myometrial interface were observed in women with excessive bleeding compared to those with moderate/heavy bleeding. Inhibition of HDAC3 resulted in disrupted NF-KB signaling, inflammation, and increased bleeding in mice with induced adenomyosis. Overall, this study highlights the importance of HDAC3 in the pathogenesis of adenomyosis-associated HMB.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Reproductive Biology
Andrea Romano, Sun-Wei Guo, Jan Brosens, Asgerally Fazlebas, Caroline E. Gargett, Stefan Giselbrecht, Martin Gotte, Linda Griffith, Hugh S. Taylor, Robert N. Taylor, Hugo Vankelecom, Charles Chapron, Xiao-Hong Chang, Khaleque N. Khan, Paola Vigano
Summary: This article presents the protocol for a Delphi process to develop a consensus on in vitro methodologies using endometrial cells. By selecting critical methodologies, topics, and items, and conducting surveys and ratings, unbiased guidance for research methods is promoted to increase confidence in the reliability of in vitro models.
REPRODUCTION AND FERTILITY
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
