Article
Pharmacology & Pharmacy
Peter Kolkhof, Amer Joseph, Ulrich Kintscher
Summary: Over the past 30 years, there has been significant progress in understanding the role of aldosterone and mineralocorticoid receptor in cardiovascular and kidney diseases. Ongoing research is focused on developing safer and more effective nonsteroidal MR antagonists.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Gates B. Colbert, Mohamed E. Elrggal, Anna Gaddy, Hector M. Madariaga, Edgar V. Lerma
Summary: Hypertension is a key factor in the progression of cardiovascular disease in patients with chronic kidney disease, particularly diabetic kidney disease. Controlling hypertension can delay the progression of diabetic kidney disease. Several medications have been proven effective in real-world use, and new drugs are emerging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Daiji Kawanami, Yuichi Takashi, Yoshimi Muta, Naoki Oda, Dai Nagata, Hiroyuki Takahashi, Makito Tanabe
Summary: Diabetic kidney disease is a major cause of end-stage kidney disease worldwide, with the mineralocorticoid receptor playing an important role in its development. Clinical studies have shown the benefits of MR antagonists for DKD, but concerns remain about their selectivity and hyperkalemia risks. New nonsteroidal MRAs, such as finerenone, have been developed with high selectivity and potent anti-inflammatory and anti-fibrotic properties, and a lower risk of hyperkalemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ulrich Kintscher, George L. Bakris, Peter Kolkhof
Summary: This review provides information on the molecular pharmacology and relevant clinical data of a new class of non-steroidal MRAs, discussing their cardiorenal outcomes. These compounds have an improved benefit-risk profile in treating cardiovascular diseases, and finerenone has a novel indication.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study found that female patients with bilateral primary aldosteronism have worse renal outcomes compared to male patients after receiving mineralocorticoid receptor antagonist treatment. Despite similar systolic blood pressure levels between the sexes, women experienced a greater decline in estimated glomerular filtration rate, especially during the late phase of 6 to 60 months post-treatment initiation.
Article
Cardiac & Cardiovascular Systems
Brett W. Sperry, Mazen Hanna, Sanjiv J. Shah, Wael A. Jaber, John A. Spertus
Summary: The study investigated an enriched cohort of HFpEF patients with cardiac amyloidosis phenotype in TOPCAT, finding that these patients had the worst prognosis but benefitted similarly from spironolactone therapy.
JACC-HEART FAILURE
(2021)
Article
Urology & Nephrology
Katja Luettges, Marlies Bode, Jan Niklas Diemer, Juliane Schwanbeck, Eva K. Wirth, Robert Klopfleisch, Kai Kappert, Arne Thiele, Daniel Ritter, Anna Foryst-Ludwig, Peter Kolkhof, Ulrich Otto Wenzel, Ulrich Kintscher
Summary: This study investigated the anti-inflammatory/fibrotic and immunological effects of the nonsteroidal MR antagonist finerenone in a cardiorenal disease model. The results showed that finerenone could alleviate cardiorenal damage, reduce blood pressure, decrease renal inflammatory cell content, and improve cardiac function.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michael Crompton, Laura J. Skinner, Simon C. Satchell, Matthew J. Butler
Summary: The renin angiotensin aldosterone system plays a crucial role in blood pressure regulation. Excessive stimulation of mineralocorticoid receptors by aldosterone can lead to various pathological effects in the heart, kidney, and endothelial cells. In this article, we discussed the association between hyperaldosteronism and fibrosis, cardiac dysfunction, maladaptive hypertrophy, proteinuria, and fibrosis. We also reviewed how aldosterone exposure damages the endothelial glycocalyx and suggested that preventing glycocalyx remodeling may offer a novel strategy for limiting endothelial damage.
Article
Peripheral Vascular Disease
Sho Katsuragawa, Atsushi Goto, Satoru Shinoda, Kosuke Inoue, Kazuki Nakai, Jun Saito, Tetsuo Nishikawa, Yuya Tsurutani
Summary: The study suggests that reversing renin suppression with optimal mineralocorticoid receptor antagonist titration may help mitigate adverse renal outcomes in medically treated primary aldosteronism patients.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor (MR) antagonists, also known as aldosterone blockers, have shown clinical benefits in treating patients with heart failure, including those with reduced ejection fraction and preserved ejection fraction with reduced left ventricular filling. The MR has various physiological and pathophysiological roles in the heart, vasculature, and other tissues, which underpin the use of MR antagonists in cardiovascular disease, particularly heart failure. The development of MR antagonists has progressed from potassium-sparing diuretics to more receptor-selective options, demonstrating the evolution of treatment options for cardiovascular diseases.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor antagonists, also known as aldosterone blockers, have been widely recognized for their clinical benefits in treating heart failure, improving outcomes for both HFrEF and HFpEF patients. As research continues to evolve, new nonsteroidal receptor antagonists like esaxerenone and finerenone have emerged, showcasing the constantly evolving landscape of cardiovascular disease treatment.
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Kristina S. LyngsO, Boye L. Jensen, Pernille B. L. Hansen, Henrik Dimke
Summary: The study found that aldosterone impairs endothelial function in a murine model of experimental diabetes through activation of endothelial cell mineralocorticoid receptors. This may explain the cardiovascular protection by mineralocorticoid receptor antagonists in diabetes.
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Stefan D. Anker, Rajiv Agarwal, Luis M. Ruilope, Peter Rossing, George L. Bakris, Christoph Tasto, Amer Joseph, Peter Kolkhof, Andrea Lage, Bertram Pitt
Summary: Finerenone reduces the incidence of new-onset HF and improves other HF outcomes in patients with chronic kidney disease and type 2 diabetes, regardless of a history of HF.
Article
Medicine, General & Internal
Holger Schneider, Anna-Lina Sarkis, Lisa Sturm, Vera Britz, Andreas Lechner, Anne L. Potzel, Lisa Marie Mueller, Daniel A. Heinrich, Heike Kuenzel, Hanna F. Nowotny, Thomas Marchant Seiter, Sonja Kunz, Martin Bidlingmaier, Martin Reincke, Christian Adolf
Summary: This study aimed to investigate the antihypertensive impact of a moderate dietary salt restriction in patients with primary aldosteronism (PA). The results showed that the dietary salt restriction significantly reduced blood pressure and depressive symptoms in patients. Furthermore, the study found that an adequate dosage of renin-angiotensin-aldosterone-system (RAAS) blockers enhanced the effects of salt restriction on blood pressure and cardiovascular risk.
JOURNAL OF INTERNAL MEDICINE
(2023)
Meeting Abstract
Biophysics
Thassio Mesquita, Gaelle Auguste, Jessica Sabourin, Gema Ruiz-Hurtado, Valerie Rouffiac, Florian Le-Billan, Jerome Fagart, Florence Lefebvre, Say Viengchareun, Eric Morel, Ana Maria Gomez, Marc Lombes, Jean Pierre Benitah
BIOPHYSICAL JOURNAL
(2016)
Article
Endocrinology & Metabolism
Narender Kumar, Jerome Fagart, Philippe Liere, Scott J. Mitchell, Alanah R. Knibb, Isabelle Petit-Topin, Marion Rame, Martine El-Etr, Michael Schumacher, Jeremy J. Lambert, Marie-Edith Rafestin-Oblin, Regine Sitruk-Ware
Article
Genetics & Heredity
Geraldine Vitellius, Jerome Fagart, Brigitte Delemer, Larbi Amazit, Nelly Ramos, Jerome Bouligand, Florian Le Billan, Frederic Castinetti, Anne Guiochon-Mantel, Severine Trabado, Marc Lombes
Article
Endocrinology & Metabolism
Valerie Bernard, Sakina Kherra, Bruno Francou, Jerome Fagart, Say Viengchareun, Jerome Guechot, Asmahane Ladjouze, Anne Guiochon-Mantel, Kenneth S. Korach, Nadine Binart, Marc Lombes, Sophie Christin-Maitre
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Endocrinology & Metabolism
Justine Bouilly, Isabelle Beau, Sara Barraud, Valerie Bernard, Kemal Azibi, Jerome Fagart, Anne Fevre, Anne Laure Todeschini, Reiner A. Veitia, Cherif Beldjord, Brigitte Delemer, Catherine Dode, Jacques Young, Nadine Binart
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Multidisciplinary Sciences
Ingrid Lema, Larbi Amazit, Khadija Lamribet, Jerome Fagart, Anne Blanchard, Marc Lombes, Nadia Cherradi, Say Viengchareun
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Florian Le Billan, Larbi Amazit, Kevin Bleakley, Qiong-Yao Xue, Eric Pussard, Christophe Lhadj, Peter Kolkhof, Say Viengchareun, Jerome Fagart, Marc Lombes
Article
Genetics & Heredity
Clemente Delcour, Larbi Amazit, Liliana C. Patino, Francoise Magnin, Jerome Fagart, Brigitte Delemer, Jacques Young, Paul Laissue, Nadine Binart, Isabelle Beau
GENETICS IN MEDICINE
(2019)
Article
Cell Biology
Simon Bucher, Dounia Le Guillou, Julien Allard, Gregory Pinon, Karima Begriche, Arnaud Tete, Odile Sergent, Dominique Lagadic-Gossmann, Bernard Fromenty
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Nutrition & Dietetics
Simon Bucher, Karima Begriche, Daniel Catheline, Viviane Trak-Smayra, Francois Tiaho, Cedric Coulouarn, Gregory Pinon, Dominique Lagadic-Gossmann, Vincent Rioux, Bernard Fromenty
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
N. Mohammad Ozeir, Jessica Huyet, Marie-Claude Burgevin, Benoit Pinson, Francoise Chesney, Jean-Marc Remy, Abdul Rauf Siddiqi, Roland Lupoli, Grgory Pinon, Christelle Saint-Marc, Jean-Francois Gibert, Renaud Morales, Irene Ceballos-Picot, Robert Barouki, Bertrand Daignan-Fornier, Anne Olivier-Bandini, Franck Auge, Pierre Nioche
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Endocrinology & Metabolism
Simon Travers, Claire Bouvattier, Jerome Fagart, Laetitia Martinerie, Say Viengchareun, Eric Pussard, Marc Lombes
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Florian Le Billan, Julie Perrot, Elena Carceller, Simon Travers, Say Viengchareun, Peter Kolkhof, Marc Lombes, Jerome Fagart
Summary: The study analyzed the effects of two MRAs on the aldosterone-induced transcriptome in a human renal cell line, revealing the regulation of hundreds of genes by aldosterone and the quantitative efficiency of finerenone on certain aldosterone-induced genes. The data provides insights into the mechanisms of MR signaling pathway and potential therapeutic targets for renal dysfunction.
Article
Biochemistry & Molecular Biology
Jessica Huyet, Mohammad Ozeir, Marie-Claude Burgevin, Benoit Pinson, Francoise Chesney, Jean-Marc Remy, Abdul Rauf Siddiqi, Roland Lupoli, Gregory Pinon, Christelle Saint-Marc, Jean-Francois Gibert, Renaud Morales, Irene Ceballos-Picot, Robert Barouki, Bertrand Daignan-Fornier, Anne Olivier-Bandini, Franck Auge, Pierre Nioche
CELL CHEMICAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ingrid Lema, Larbi Amazit, Khadija Lamribet, Jerome Fagart, Anne Blanchard, Marc Lombes, Nadia Cherradi, Say Viengchareun
CELLULAR AND MOLECULAR LIFE SCIENCES
(2017)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)