Article
Reproductive Biology
A. K. Talukder, M. B. Rabaglino, J. A. Browne, G. Charpigny, P. Lonergan
Summary: This study aimed to investigate the dose- and time-dependent relationship between IFNT and the expression of ISGs in the endometrium, as well as its impact on the maternal recognition of pregnancy in cattle. The results indicated that IFNT acts on the uterus in a dose- and time-dependent manner, and timely exposure to sufficient IFNT is crucial for the establishment of successful pregnancy.
Article
Multidisciplinary Sciences
Monika Baryla, Ewelina Goryszewska-Szczurek, Piotr Kaczynski, Gianfranco Balboni, Agnieszka Waclawik
Summary: This study investigated the role of Prokineticin 1 (PROK1) in the corpus luteum (CL) during pregnancy and found that PROK1 is essential for regulating steroidogenesis, luteal cell apoptosis and viability, and angiogenesis in maintaining luteal function.
SCIENTIFIC REPORTS
(2023)
Article
Reproductive Biology
Makenzie G. Newton, Claire Stenhouse, Katherine M. Halloran, Nirvay Sah, Robyn M. Moses, Wenliang He, Guoyao Wu, Fuller W. Bazer
Summary: The synthesis and secretion of polyamines in the uterus of ewes are regulated by changes in progesterone, estradiol, and their receptors. These hormones and receptors play important roles in the reproductive performance of mammals by affecting the secretion and transport of nutrients in the uterine lumen.
BIOLOGY OF REPRODUCTION
(2023)
Review
Agriculture, Dairy & Animal Science
Cecilia Constantino Rocha, Juliano Coelho Da Silveira, Niamh Forde, Mario Binelli, Guilherme Pugliesi
Summary: This review focuses on the innate immune events modulated by conceptus signaling during early pregnancy in ruminants, with a special emphasis on the role of IFN-tau in regulating the immune system to prevent conceptus rejection.
ANIMAL REPRODUCTION
(2021)
Review
Developmental Biology
Aleona Swegen
Summary: Maternal recognition of pregnancy is crucial for ensuring a supportive environment for pregnancy continuation in horses, but the mechanism remains unknown. This review addresses controversies and challenges in studying MRP in horses, as well as the new research tools that will drive progress in the coming years.
Article
Food Science & Technology
Maria Rosa Ramos Nieto, Marianela Lasagna, Gabriel Cao, Gloria Alvarez, Clarisa Santamaria, Maria Eugenia Rodriguez Girault, Nadia Bourguignon, Noelia Di Giorgio, Clara Ventura, Mariana Mardirosian, Horacio Rodriguez, Victoria Lux-Llantos, Claudia Cocca, Mariel Nunez
Summary: The study found that chronic exposure to low concentrations of CPF affects ovarian steroid synthesis in female rats, leading to changes in the estrous cycle of animals, as well as proliferative changes in the uterus.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Li-Ge Bu, Bo Wang, Ting-Yue Li, Ya Sun, Li-Li Kong, Zhen-Ao Zhao, Shi-Jie Li, Nai-Zheng Ding, Hua Ni
Summary: This study found that FOXO1 plays a key role in conceptus adhesion in goats during early pregnancy, and it modulates the synthesis of prostaglandins by regulating the transcription of PTGS2. IFNT upregulates the levels of FOXO1 and PTGS2. These findings contribute to a better understanding of the function of FOXO1 in the reproductive implantation of small ruminants.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Ewa Mlyczynska, Ewa Zaobidna, Edyta Rytelewska, Kamil Dobrzy, Grzegorz Kopij, Karolina Szymanska, Patrycja Kurowska, Cecylia Dall'Aglio, Nina Smolinska, Tadeusz Kaminski, Agnieszka Rak
Summary: Visfatin/NAMPT is a hormone that connects energy metabolism with female reproduction. This study investigates the expression and localization of visfatin in the corpus luteum (CL) and its regulation by hormones such as LH, insulin, progesterone, prostaglandin E2, and F2 alpha. The study finds that visfatin expression in the porcine CL depends on the hormonal status of the estrous cycle or early pregnancy and is regulated by LH, insulin, progesterone, and prostaglandins through the ERK1/2 pathway.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Reproductive Biology
Heather L. Chaney, Lindsay F. Grose, Gilles Charpigny, Susanta K. Behura, I. Martin Sheldon, James G. Cronin, Patrick Lonergan, Thomas E. Spencer, Daniel J. Mathew
Summary: This study identified biologically relevant IFNT-stimulated genes in specific endometrial cell types. The findings provide critical information on the effects of conceptus IFNT on specific endometrial compartments during early developmental processes in cattle.
BIOLOGY OF REPRODUCTION
(2021)
Article
Reproductive Biology
Marlena Gudelska, Kamil Dobrzyn, Marta Kiezun, Katarzyna Kisielewska, Edyta Rytelewska, Tadeusz Kaminski, Nina Smolinska
Summary: This study aimed to investigate the influence of steroid hormones on the expression of the chemerin system in the uterus of domestic pigs. The results showed that both estradiol and progesterone can modulate the expression of chemerin receptor genes and proteins, as well as the abundance of RARRES2 mRNA transcripts. Additionally, estradiol increased chemerin protein secretion during the maternal recognition of pregnancy and decreased its release during embryo implantation.
Article
Veterinary Sciences
Abdurrahman Takci, Dursun Ali Dinc
Summary: This study investigated the effectiveness of resynchronization during anestrus for the first time in the literature. The results showed that performing two consecutive stimulations can increase pregnancy rate and save time.
VETERINARY SCIENCES
(2023)
Article
Cell Biology
Tao Zhang, Shuai Guo, Han Zhou, Zhimin Wu, Junfeng Liu, Changwei Qiu, Ganzhen Deng
Summary: The activation of YAP is crucial for early pregnancy in bovines, as it promotes cell proliferation and creates an immunosuppressive local environment facilitating conceptus implantation into the uterine epithelium.
CELL PROLIFERATION
(2021)
Article
Agriculture, Dairy & Animal Science
Hisashi Kishi, Wataru Komatsu, Koji Uchiyama, Hidehito Takayama, Tomomi Udagawa, Shuji Ohhira, Gen Kobashi
Summary: VEGF expression in the uterus during the estrous cycle of golden hamsters (Mesocricetus auratus) was investigated. Three different VEGF isoforms (VEGF188, VEGF164, and VEGF120) were identified through reverse transcription polymerase chain reaction. VEGF164 and VEGF120 were predominantly expressed in the uterus during the estrous cycle. In situ hybridization showed that VEGF was expressed in the luminal and glandular epithelium of the endometrium. These findings indicate that VEGF secreted by endometrial epithelial cells plays a role in maintaining blood vessels in the endometrial stroma and preparing for embryo implantation.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Reproductive Biology
Agata Zmijewska, Wioleta Czelejewska, Ewa M. Drzewiecka, Anita Franczak
Summary: The pituitary gland plays a crucial role in female reproduction. However, little is known about the changes in the transcriptome of the porcine pituitary during reproductive status. This study aimed to analyze and compare the transcriptome profile of the pituitary gland in pregnant pigs and pigs during the estrous cycle. The analysis revealed 482 differentially expressed genes, with 68 up-regulated and 414 down-regulated in pregnant pigs. These findings provide insights into the molecular mechanisms involved in maternal recognition of pregnancy in pigs.
Article
Reproductive Biology
Piotr Kaczynski, Stefan Bauersachs, Ewelina Goryszewska, Monika Baryla, Agnieszka Waclawik
Summary: In vivo study revealed that prostaglandin E2 acting simultaneously with estradiol-17 beta induces more changes within porcine endometrial transcriptome resembling pregnancy effects compared with estradiol-17 beta administered alone.
BIOLOGY OF REPRODUCTION
(2021)
Article
Toxicology
Sakhila K. Banu, Jone A. Stanley, Kirthiram K. Sivakumar, Robert J. Taylor, Joe A. Arosh, Robert C. Burghardt
TOXICOLOGICAL SCIENCES
(2017)
Article
Toxicology
Sakhila K. Banu, Jone A. Stanley, Robert J. Taylor, Kirthiram K. Sivakumar, Joe A. Arosh, Lixia Zeng, Subramaniam Pennathur, Vasantha Padmanabhan
TOXICOLOGICAL SCIENCES
(2018)
Article
Medical Laboratory Technology
Marcus R. Orzabal, Emilie R. Lunde-Young, Josue I. Ramirez, Selene Y. F. Howe, Vishal D. Naik, Jehoon Lee, Cristine L. Heaps, David W. Threadgill, Jayanth Ramadoss
TRANSLATIONAL RESEARCH
(2019)
Article
Behavioral Sciences
Raine Lunde-Young, Josue Ramirez, Vishal Naik, Marcus Orzabal, Jehoon Lee, Kranti Konganti, Andrew Hillhouse, David Threadgill, Jayanth Ramadoss
BRAIN AND BEHAVIOR
(2019)
Review
Biochemistry & Molecular Biology
Sridhar Muthusami, Balasubramanian Vidya, Esaki M. Shankar, Jamuna Vadivelu, Ilangovan Ramachandran, Jone A. Stanley, Nagarajan Selvamurugan
CURRENT PROTEIN & PEPTIDE SCIENCE
(2020)
Article
Substance Abuse
Vishal Naik, Raine Lunde-Young, Josue Ramirez, Jehoon Lee, Jayanth Ramadoss
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Substance Abuse
Jehoon Lee, Raine Lunde-Young, Vishal Naik, Josue Ramirez, Marcus Orzabal, Jayanth Ramadoss
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Cell Biology
Joe A. Arosh, JeHoon Lee, Sakhila K. Banu
Summary: Endometriosis is an estrogen-dependent and progesterone-resistant inflammatory disease with a prevalence of 5-10% in reproductive-age women, increasing to 20-30% in women with subfertility. Dual inhibition of AKT and ERK1/2 pathways suppresses the growth of endometriotic lesions, decreases proinflammatory cytokines, E2 biosynthesis and signaling, and restores progesterone receptor-B signaling, suggesting a potential long-term nonsteroidal therapy for endometriosis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Jehoon Lee, Vishal Naik, Marcus Orzabal, Raine Lunde-Young, Jayanth Ramadoss
Summary: Prenatal alcohol exposure can lead to increased dendritic arborization in the developing rat hippocampus, potentially playing a critical role in FASD neurobiological phenotypes.
Review
Nutrition & Dietetics
Vishal D. Naik, Jehoon Lee, Guoyao Wu, Shannon Washburn, Jayanth Ramadoss
Summary: Fetal alcohol exposure can lead to developmental disorders, and inadequate nutrition can worsen these effects. This review explores the interaction between nutrition and gestational alcohol consumption on fetal growth and development, as well as the potential benefits of micronutrient supplementation.
Article
Cell Biology
Joe A. Arosh, Kirthiram K. Sivakumar, JeHoon Lee, Sakhila K. Banu
Summary: Endometriosis is a chronic inflammatory gynecological disease affecting reproductive-age women, characterized by chronic pelvic pain and infertility. Current hormonal therapies are ineffective and have undesirable side effects. Inhibition of PGE2 receptors EP2 and EP4 may present a potential nonsteroidal therapy for endometriosis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Vishal D. Naik, Jehoon Lee, Marcus O. Orzabal, Jayanth Ramadoss
Summary: This study investigated the relationship between alcohol-induced vascular dysfunction in the maternal uterine artery and phosphatidic acid (PA). The results showed that alcohol administration impaired uterine artery relaxation and reduced eNOS levels. However, supplementation of PA reversed these effects and improved vascular function. The interaction between PA concentrations and alcohol exposure was significant, suggesting a concentration-dependent vasodilatory effect. This study highlights the potential therapeutic role of PA in alcohol-related gestational vascular dysfunction.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Kumaravel Mohankumar, Jehoon Lee, Chia Shan Wu, Yuxiang Sun, Stephen Safe
Meeting Abstract
Obstetrics & Gynecology
Joe A. Arosh, Jone A. Stanley, Kaylon Bruner-Tran, Kevin K. Osteen, Sakhila K. Banu
REPRODUCTIVE SCIENCES
(2018)
Meeting Abstract
Obstetrics & Gynecology
Sakhila K. Banu, Jone A. Stanley, Kirthiram K. Sivakumar, Joe A. Arosh
REPRODUCTIVE SCIENCES
(2017)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)