Article
Endocrinology & Metabolism
Changsheng Wang, Rongsheng Chen, Xitian Zhu, Xiaobo Zhang, Nancheng Lian
Summary: The purpose of this study was to investigate the role of METTL14 in osteoporosis induced by ovariectomy (OVX) in mice. The study found that METTL14 regulates the m6A level of SIRT1 mRNA. Decreased expression of SIRT1 and METTL14 was observed in OVX mice. Overexpression of either SIRT1 or METTL14 enhanced osteoblast differentiation and suppressed osteoclast differentiation. METTL14 overexpression also increased the m6A level of SIRT1 mRNA. Furthermore, overexpression of METTL14 promoted osteoblast differentiation and suppressed osteoclast differentiation, which could be reversed by SIRT1 knockdown.
Article
Oncology
Quan Xing, Jingyi Feng, Xiaolei Zhang
Summary: The study showed that glucocorticoids inhibit osteoblast differentiation by suppressing Sema3A expression through the PI3K/Akt pathway. These findings offer new insights into the molecular mechanisms of glucocorticoid-induced osteoblast differentiation inhibition.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Charles Owen Smith, Roman A. Eliseev
Summary: This study investigates the changes in cellular bioenergetics during osteogenic differentiation, showing that osteogenic media and differentiation factors Wnt3a and BMP2 stimulate mitochondrial oxidative phosphorylation in bone progenitor cells, leading to bone formation.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Yatine Lee, Sabrina Marie Christensen, Nhi Duong, Quoc-Anh Tran, Hou Mai Xiong, Jennifer Huang, Sarah James, Dimple Vallabh, George Talbott, Melanie Rose, Linh Ho
Summary: Sirtuin-3 (Sirt3) is a mitochondrial enzyme that regulates metabolic pathways and its expression is decreased in diabetes. This study found that the activator HNK increased adipogenesis and insulin signaling pathway, while the inhibitor 3-TYP had the opposite effect. These findings suggest that Sirt3 activation improves insulin resistance, while Sirt3 inhibition may worsen insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lilla Nagy, Boglarka Rauch, Tamas Szerafin, Karen Uray, Attila Toth, Peter Bai
Summary: This study found that supplementation with nicotinamide riboside (NR) can induce the conversion of human white adipocytes to beige adipocytes, and enhance uncoupled respiration. This is beneficial for regulating organismal energy and metabolic balance, and combating metabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Isobel C. C. Jones, Revathy Carnagarin, Jo Armstrong, Daphne P. L. Lin, Mia Baxter-Holland, Mina Elahy, Crispin R. R. Dass
Summary: It has been found that PEDF can influence the insulin signaling pathway by inhibiting the phosphorylation of insulin receptor and insulin receptor substrate in skeletal myocytes. Moreover, PEDF can promote the transdifferentiation of adipocytes into osteoblasts, leading to bone formation in vitro and in vivo. Additionally, PEDF is associated with the anticancer drug doxorubicin and cellular metabolism.
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Svren Enerback
Summary: In recent years, lactate has been recognized as an important circulating energy substrate and aerobic glycolysis has been identified as a metabolic choice involving increased glucose uptake and lactate production despite normal oxygen levels. This study demonstrates that the transcription factor Foxp1 regulates glucose uptake and lactate production in adipocytes and myocytes. Foxp1 directly interacts with the promoter consensus cis-elements that regulate expression of several enzymes in the glycolytic pathway. Knockdown of Foxp1 suppresses these enzyme levels and impairs glucose uptake and lactate production. This suggests that Foxp1 plays a crucial role in regulating aerobic glycolysis in adipose tissue and muscle.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Lars Erichsen, James Adjaye
Summary: The process of aging involves various biological processes, such as genomic instability, telomere attrition, and epigenetic alterations. SIRT1, a protein involved in cellular aging, DNA damage repair, and cell differentiation, plays a crucial role in these processes.
Article
Engineering, Biomedical
Zhou-Shan Tao, Hai-Sheng Wang, Tian-Lin Li, Shan Wei
Summary: The study investigated the role of Silibinin-modified Hydroxyapatite coating in osseointegration in diabetes. The results showed that Silibinin suppressed oxidative stress, promoted osteogenic differentiation, and improved the osseointegration of diabetic rats.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
James R. W. Conway, Defne D. Dinc, Gautier Follain, Oona Paavolainen, Jasmin Kaivola, Pia Bostroem, Pauliina Hartiala, Emilia Peuhu, Johanna Ivaska
Summary: The progression from noninvasive ductal carcinoma in situ to invasive ductal carcinoma in breast cancer patients has a negative impact on prognosis and can lead to metastasis. Insulin-like growth factor-binding protein 2 (IGFBP2) secreted by healthy breast adipocytes has been identified as a potent adipocrine factor that acts as a barrier against invasive progression. Adipocytes derived from patient stromal cells were found to secrete IGFBP2, which effectively inhibited breast cancer invasion by sequestering cancer-derived IGF-II. Depleting IGF-II in invading cancer cells using RNAs or an IGF-II-neutralizing antibody prevented breast cancer invasion, emphasizing the importance of IGF-II autocrine signaling in invasive progression.
Article
Oncology
Jun Dong, Xiqiang Xu, Qingyu Zhang, Zenong Yuan, Bingyi Tan
Summary: The PTEN/PI3K/AKT signaling pathway plays a crucial role in BMP2-induced osteogenic differentiation and ectopic bone formation, indicating its potential as a therapeutic target for heterotopic ossification (HO). Targeting this pathway with inhibitors may represent a promising molecular therapy for HO treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Plant Sciences
Pin Gong, Xuyang Xiao, Shuang Wang, Fuxiong Shi, Ni Liu, Xuefeng Chen, Wenjuan Yang, Lan Wang, Fuxin Chen
Summary: Astragaloside IV (AS-IV) significantly reversed abnormalities in diabetic mice, protected cellular architecture, and regulated intestinal flora. Its anti-diabetic effects are mediated through modulating the AMPK/SIRT1 and PI3K/AKT signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenxia Ren, Miaomiao Chai, Mingli Jiang, Yan Zhou, Wensong Tan
Summary: The study found that high glucose induced apoptosis in mesenchymal stem cells, but simultaneously promoted their osteogenic differentiation. This was achieved through the downregulation of the AKT-Sirt1-TWIST pathway by high glucose.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Hang-Bing Dai, Hong-Yu Wang, Fang-Zheng Wang, Pei Qian, Qing Gao, Hong Zhou, Ye-Bo Zhou
Summary: This study demonstrates the protective effects of ADM against IR, inflammation, and oxidative stress in adipocytes, as well as its regulatory effects on these factors in obese rats. These findings suggest that ADM may have the potential to prevent obesity-related metabolic disorders.
ACTA DIABETOLOGICA
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)