Article
Endocrinology & Metabolism
Kelly L. Walton, Monica P. Goney, Zoe Peppas, Jessica M. Stringer, Amy Winship, Karla Hutt, Georgia Goodchild, Shreya Maskey, Karen L. Chan, Emilie Brule, Daniel J. Bernard, William A. Stocker, Craig A. Harrison
Summary: This study reveals novel effects of inhibins in the establishment and maintenance of pregnancy and demonstrates that partial inactivation of inhibin A/B is an attractive approach for enhancing female fertility.
Article
Biochemistry & Molecular Biology
Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar
Summary: GnRH3 neurons play a crucial role in the reproduction of zebrafish females, independent of GnRH3 peptides. The number of GnRH3 neurons does not directly affect reproductive performance, suggesting that GnRH and its neurons may be dispensable for ovulation in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Katie L. Land, Madison E. Lane, Ava C. Fugate, Patrick R. Hannon
Summary: This study investigated the effects of phthalates on ovulation and found that phthalates can directly inhibit ovulation by decreasing prostaglandin levels, altering progesterone/PGR action, and affecting extracellular matrix remodeling.
TOXICOLOGICAL SCIENCES
(2021)
Article
Biology
Erica J. Graham, Noemie Elhadad, David Albers
Summary: A normally functioning menstrual cycle requires communication between hormones in the ovaries and brain tissues. Hormonal dysregulation can lead to abnormal function and infertility. Developing a new endocrine model and using simulated unknown parameters, we identified mechanisms that differentiate normal and abnormal phenotypes. We also discovered an intermediate phenotype, showing normal hormone levels and cycle dynamics, statistically similar to the irregular phenotype. This study highlights the importance of considering clinical symptoms in addition to hormone measurements.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xingfa Han, Xue Xia, Weihao Chen, Fengyan Meng, Xiaohan Cao, Guixian Bu, Tian Gan, Xiaogang Du, Qiuxia Liang, Xianyin Zeng
Summary: Inhibins suppress FSH production by binding to ACTR II receptors and their co-receptor betaglycan. A 13-amino-acid peptide sequence in the inhibin alpha subunit, which is conserved across species, was identified as the critical binding site for betaglycan. Immunization with a novel inhibin vaccine based on this peptide sequence increased FSH levels, ovarian follicle development, ovulation rate, and litter sizes in female rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Ai-Min Yang, Na Cui, Yi-Fei Sun, Gui-Min Hao
Summary: Letrozole, as an aromatase inhibitor, has been widely used in infertility treatments, with its efficacy and safety confirmed by accumulating clinical and basic evidence. This review focuses on the current knowledge of the applications and mechanisms of letrozole in female infertility, and raises various questions on how it could be used more effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Dan Wu, Huan Shen
Summary: This study aimed to investigate the effectiveness and safety of fertility counseling and fertility preservation through oocyte or embryo freezing in female patients with hematologic disorders before undergoing chemotherapy or bone marrow transplantation (BMT). Results showed that oocyte or embryo freezing prior to treatment can offer hope for fertility preservation in female patients with hematologic disorders. However, a standardized and feasible treatment process that covers all aspects, from patient selection to protocols for ovulation promotion and postoperative observation, is necessary.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Cell Biology
Andreina Arias, Alonso Quiroz, Nicolas Santander, Eugenia Morselli, Dolores Busso
Summary: Cholesterol plays a crucial role in maintaining the proper functioning of animal cells. Abnormal metabolism of high-density lipoproteins (HDL) may affect female fertility. HDL in follicular fluid (FF) can uptake excess unesterified cholesterol (UC) from cumulus cells, and the accumulation of UC may impair the developmental capacity of the egg. Cholesterol accumulation can affect cell viability and the activity of membrane proteins, potentially through the activation of calcium channels and dysregulation of cell death/survival signaling pathways. Evaluating cholesterol and lipid levels is important for the diagnosis and treatment of infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaru Chen, Jiawei Zhou, Shang Wu, Lei Wang, Gaogui Chen, Dake Chen, Xianwen Peng, Yi-Liang Miao, Shuqi Mei, Fenge Li
Summary: The present study reveals that ISG15 knockout leads to hyperfertility in mice, accompanied by sensitive ovarian responses to gonadotropin. It is demonstrated that ISG15 represses the expression of ovulation-related genes in an ISGylation-dependent manner. Furthermore, ISG15 binds to ADAMTS1 and induces its degradation through the 20S proteasome-dependent pathway, thus compromising ovulation and female fertility.
CELL AND BIOSCIENCE
(2023)
Article
Reproductive Biology
Ming-Hua Zeng, Yan Wang, Hua-Lin Huang, Ru-Ping Quan, Jun-Ting Yang, Dan Guo, Ying Sun, Chao Lv, Tian-Ying Li, Le Wang, Hang-Jin Tan, Pan-Pan Long, Hong-Wen Deng, Hong-Mei Xiao
Summary: The zona pellucida (ZP) is essential for female fertility in mammals, with ZP1-3 playing important roles. However, the function of ZP4 remains poorly understood. A study on Zp4 knockout (KO) rats found that Zp4 was dispensable for female fertility, as it did not affect ZP morphology or reproductive processes.
BIOLOGY OF REPRODUCTION
(2021)
Article
Reproductive Biology
Linah Al-Alem, Muraly Puttabyatappa, Ketan Shrestha, Yohan Choi, Kathy Rosewell, Mats Brannstrom, James Akin, Misung Jo, Diane M. Duffy, Thomas E. Curry
Summary: The study found that NTS expression in the ovaries of humans and rats significantly increased during ovulation, possibly regulated by the epidermal growth factor pathway and protein kinase A pathway. NTS may regulate crucial aspects of ovulation such as vascular permeability, inflammation, and cell migration.
BIOLOGY OF REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Wei Liu, Xinyu Wang, Yating Chen, Huiyu Zhang, Jing Chen, Jing Zhang, Tinghe Wu, Jing Li
Summary: The combination DACHAO developed in this study improved ovarian functions in women at advanced maternal age by enhancing mitochondrial functions, blastocyst formation, and fertility, while reducing apoptosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tomoya Nakanishi, Risa Tanaka, Shingo Tonai, Joo Yeon Lee, Manami Yamaoka, Tomoko Kawai, Asako Okamoto, Masayuki Shimada, Yasuhisa Yamashita
Summary: In the ovaries of immature mice, gonadotropins regulate the expression of SREBP and its regulators, SCAP and INSIG1, which play key roles in cholesterol biosynthesis and progesterone production. Overexpression of SREBP and downregulation of INSIG1 after hCG stimulation were found to activate de novo cholesterol biosynthesis, essential for ovulation and oocyte rupture.
Article
Endocrinology & Metabolism
Tomoya Nakanishi, Risa Tanaka, Shingo Tonai, Joo Yeon Lee, Manami Yamaoka, Tomoko Kawai, Asako Okamoto, Masayuki Shimada, Yasuhisa Yamashita
Summary: The study demonstrated that the downregulation of INSIG1 after hCG stimulation activated SREBP-induced de novo cholesterol biosynthesis in granulosa cells of preovulatory follicles, essential for progesterone production and the rupture of matured oocyte during ovulation.
Article
Multidisciplinary Sciences
Ryota Futamata, Masato Kinoshita, Katsueki Ogiwara, Noriyuki Kioka, Kazumitsu Ueda
Summary: In this study, the researchers found that ABCA1 deficiency in the Japanese medaka fish inhibits successful ovulation through cholesterol accumulation in the ovarian follicle. ABCA1A in the theca cells regulates cholesterol content in the ovarian follicles.
Article
Biochemistry & Molecular Biology
Andres D. Klein, Javier Gonzalez de la Vega, Silvana Zanlungo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
M. J. Yanez, T. Marin, E. Balboa, A. D. Klein, A. R. Alvarez, S. Zanlungo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Public, Environmental & Occupational Health
Dolores Busso, Guadalupe Echeverria, Alvaro Passi-Solar, Fernanda Morales, Marcelo Farias, Paula Margozzini
Summary: According to the 2016-2017 National Health Survey, folate deficiency is almost non-existent in women of childbearing age in the Metropolitan Region of Chile, suggesting that mandatory fortification of folic acid is an effective measure.
PUBLIC HEALTH NUTRITION
(2021)
Article
Multidisciplinary Sciences
Pablo S. Contreras, Pablo J. Tapia, Lila Gonzalez-Hodar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis Martinez, Elisa Balboa, Juan Castro, Nancy Leal, Frances M. Platt, Andrzej Sobota, Dominic Winter, Andres D. Klein, Diego L. Medina, Andrea Ballabio, Alejandra R. Alvarez, Silvana Zanlungo
Article
Pathology
Elsa Meneses-Salas, Marta Garcia-Forn, Carla Castany-Pladevall, Albert Lu, Alba Fajardo, Jaimy Jose, Mohamed Wahba, Marta Bosch, Albert Pol, Francesc Tebar, Andres D. Klein, Silvana Zanlungo, Esther Perez-Navarro, Thomas Grewal, Carlos Enrich, Carles Rentero
Summary: In NPC disease, lack of ANXA6 does not reverse neurological and motor dysfunction, but exacerbates hepatic dysfunction and decreases lifespan.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. J. Yanez, F. Campos, T. Marin, A. D. Klein, A. H. Futerman, A. R. Alvarez, S. Zanlungo
Summary: This study reveals that c-Abl tyrosine kinase participates upstream of RIPK3 in Gaucher disease, with its inhibition showing potential therapeutic benefits. The interaction and phosphorylation of RIPK3 by c-Abl was reduced with pharmacological intervention, highlighting c-Abl signaling as a novel pathway for potential GD treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Nutrition & Dietetics
Dolores Busso, Andrea David, Reyna Penailillo, Guadalupe Echeverria, Attilio Rigotti, Irina Kovalskys, Georgina Gomez, Lilia Yadira Cortes Sanabria, Martha Cecilia Yepez Garcia, Rossina G. Pareja, Marianella Herrera-Cuenca, Mauro Fisberg
Summary: Research found that vitamin E intake is inadequate in Latin American women of reproductive age, while vitamin C intake is relatively sufficient. The main food sources of vitamin E are fats and oils, as well as vegetables, while vitamin C intake is mainly from fruit juices, fruits, and vegetables. Additionally, a third of Latin American women were found to have deficient intake of both vitamins, highlighting the need for further research in this area.
Article
Cell Biology
Elisa Balboa, Tamara Marin, Juan Esteban Oyarzun, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Summary: This study identified potential therapeutic targets for the treatment of liver damage in NPCD by analyzing the pathophysiology of liver damage caused by NPCD and finding significant changes in expression levels of proteins related to liver damage, lipid metabolism, and inflammation. Lysosomal and mitochondrial proteins were found to play important roles in liver fibrosis, damage, and steatosis, validating the dataset.
Article
Cell Biology
Tamara Marin, Andres E. Dulcey, Fabian Campos, Catalina de la Fuente, Mariana Acuna, Juan Castro, Claudio Pinto, Maria Jose Yanez, Cristian Cortez, David W. McGrath, Pablo J. Saez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugan, Alejandra R. Alvarez, Silvana Zanlungo
Summary: Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder. Recent studies have shown that c-Abl tyrosine kinase activity plays a role in neuronal damage and death in NPA disease. There is potential for the use of c-Abl inhibitors in the clinical treatment of NPA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Nohela B. Arevalo, Cristian M. Lamaizon, Viviana A. Cavieres, Patricia V. Burgos, Alejandra R. alvarez, Maria J. Yanez, Silvana Zanlungo
Summary: Gaucher disease (GD) is a genetic disorder caused by mutations in the GBA1 gene, leading to GluCer accumulation in lysosomes. Previous studies have focused on lysosomal dysfunction, but recent evidence suggests alterations in other organelles such as the endoplasmic reticulum (ER) and mitochondria. This review collects evidence of organelle dysfunction beyond lysosomes in neuronopathic Gaucher disease (nGD).
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Daniela A. Gutierrez, America Chandia-Cristi, Maria Jose Yanez, Silvana Zanlungo, Alejandra R. Alvarez
Summary: This review focuses on the role of the non-receptor tyrosine kinase c-Abl in synaptic and neuronal functions. It has been found that the activation of c-Abl can be detrimental to neurons and may promote the development of neurodegenerative diseases. However, c-Abl activity plays a pivotal role in healthy synaptic plasticity, dendritic spine remodeling, and gene expression regulation after cognitive training.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Jonathan Lagos, Sara Sagadiev, Jheimmy Diaz, Juan Pablo Bozo, Fanny Guzman, Caroline Stefani, Silvana Zanlungo, Mridu Acharya, Maria Isabel Yuseff
Summary: TLR stimulation induces autophagy in B cells and decreases their capacity to extract and present immobilized antigens. This is achieved by triggering autophagy-dependent degradation of GEF-H1, which restricts lysosome repositioning to the immune synapse. The degradation of GEF-H1 is not observed in B cells deficient in TLR-induced autophagy.
Editorial Material
Cell Biology
Silvana Zanlungo, Carlos Enrich, Volker Gerke, Emily R. Eden, Maria Isabel Colombo
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anyelo Duran, David A. Priestman, Macarena Las Heras, Boris Rebolledo-Jaramillo, Valeria Olguin, Juan F. Calderon, Silvana Zanlungo, Jaime Gutierrez, Frances M. Platt, Andres D. Klein
Summary: Using a systems genetics approach, we identified 30 shared predicted modifier genes between hepatic lysosomal enzymes and glycosphingolipids (GSLs), clustered in three pathways and associated with other diseases. Surprisingly, these genes are regulated by ten common transcription factors and miRNA-340p. These findings suggest novel therapeutic targets for Lysosomal Storage Disorders (LSDs) and indicate the potential involvement of GSL metabolism in other pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anyelo Duran, Boris Rebolledo-Jaramillo, Valeria Olguin, Marcelo Rojas-Herrera, Macarena Las Heras, Juan F. Calderon, Silvana Zanlungo, David A. Priestman, Frances M. Platt, Andres D. Klein
Summary: The study identified potential genetic modifiers of GCase activity by measuring hepatic GCase in inbred mouse strains and performing a GWAS. Candidate modifier genes such as Dmrtc2, Arhgef1, and Grik5 were found, and integrative networks were built using Bayesian integration of gene mapping and transcriptomics. Analysis revealed modules like acute phase response, acute inflammatory response, and fatty acid beta-oxidation as additional candidate GCase regulators.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
