Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Biochemistry & Molecular Biology
Yu Chen, Zhengyi Zhen, Lingjiang Chen, Hao Wang, Xuhui Wang, Xiaoxiang Sun, Zhiwei Song, Haiyan Wang, Yizi Lin, Wenjun Zhang, Guizhu Wu, Ying Jiang, Zhiyong Mao
Summary: Aging is accompanied by decreased DNA repair capacity, which contributes to age-associated functional decline in multiple tissues. Hormone signaling disruption, associated with reproductive organ dysfunction, is an early event of tissue degeneration, but its impact on DNA repair in nonreproductive organs is unclear. This study shows that the downregulation of XRCC4 expression, involved in DNA repair, is mediated through transcriptional mechanisms. The androgen receptor directly binds to and enhances the activity of the XRCC4 promoter, stabilizing the genome. DHT treatment reverses senescence-associated phenotypes, providing a potential avenue for aging interventions.
Article
Biochemistry & Molecular Biology
Kaitao Li, Yang Sun, Shizhao Liu, Yi Zhou, Qian Qu, Gaofeng Wang, Jin Wang, Ruosi Chen, Zhexiang Fan, Bingcheng Liu, Yuning Li, Xiaoyan Mao, Zhiqi Hu, Yong Miao
Summary: The study found that miR-221 significantly suppressed hair growth and proliferation in AGA patients. Mechanistic analysis revealed that AR directly promoted miR-221 transcription, leading to the inactivation of the MAPK pathway in DPCs and the PI3K/AKT pathway in DSCs. MiR-221 could serve as a novel biomarker and potential therapeutic target for treating AGA.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chiara Chiodo, Catia Morelli, Fabiola Cavaliere, Diego Sisci, Marilena Lanzino
Summary: This article reviews the challenges of breast cancer prevention and highlights the role of steroid hormones and their receptors in the development of the disease. It specifically focuses on the impact of androgens and their receptor on breast tissue and their correlation to breast cancer risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ik Jun Moon, Hae Kyeong Yoon, Doyeun Kim, Myung Eun Choi, Seung Hee Han, June Hyun Park, Sun Woo Hong, Hyesoo Cho, Dong-Ki Lee, Chong Hyun Won
Summary: This study evaluated the therapeutic potential of a cell-penetrating, AR-targeting asiRNA for AGA treatment, which effectively downregulated AR expression, prevented DHT-mediated hair changes, and promoted hair growth in mouse models.
MOLECULAR PHARMACEUTICS
(2023)
Article
Agriculture, Dairy & Animal Science
Hongwei Duan, Longfei Xiao, Wenbo Ge, Shanshan Yang, Yuting Jiang, Jianshu Lv, Junjie Hu, Yong Zhang, Xingxu Zhao, Yongli Hua
Summary: The study found that 5 alpha-reductases and androgen receptors are expressed in ovine ovaries, with the expression of 5 alpha-reductases increasing as follicles develop, while androgen receptor levels decrease. FSH and LH can upregulate 5 alpha-reductases in sheep granulosa cells, leading to a reduction in DHT levels and an increase in estradiol synthesis.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Pharmacology & Pharmacy
Ja Yeon Park, Woo Yong Park, Gahee Song, Se Jin Jung, Beomsu Kim, Minji Choi, Sang Hee Kim, Jinbong Park, Hyun Jeong Kwak, Kwang Seok Ahn, Jun Hee Lee, Jae-Young Um
Summary: This study aimed to investigate the therapeutic effects of Panax ginseng water extract (PGWE) on benign prostatic hyperplasia (BPH) and its potential in treating side effects related to finasteride (Fi), an FDA-approved drug for BPH. The results showed that PGWE alleviated BPH symptoms and downregulated androgen-related factors. PGWE also induced prostatic cell apoptosis and improved sperm count in BPH rats. Furthermore, PGWE protected against Fi-induced sperm loss without compromising the therapeutic effects of Fi on BPH. These findings suggest that PGWE could be an alternative therapeutic agent for BPH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: The therapeutic effect of a combination of tomato lipidic extract (STE) and selenium (Se) on rats with prostatic hyperplasia (PH) was evaluated, and its possible mechanisms of action and synergism versus finasteride were observed. The results demonstrated that the combination of STE + Se had a greater therapeutic effect in reducing prostate weight, glandular hyperplasia, oxidative stress, dihydrotestosterone (DHT) and androgen receptor (AR) expression compared to finasteride.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: This study evaluated the therapeutic effect of a tomato lipidic extract in combination with selenium on rats with prostatic hyperplasia, and observed its possible mechanisms of action and synergism with finasteride. The results showed that the combination of tomato lipidic extract and selenium had a greater therapeutic effect compared to finasteride, without increasing prooxidant activity.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marton A. Kiss, Miroslav Perina, Laura Bereczki, Adam Baji, Jakub Belicek, Radek Jorda, Eva Frank
Summary: Dysfunction of the androgen receptor signalling axis is important in prostate cancer development and progression. A series of A-ring-fused pyridine compounds were synthesized, and one derivative, 1d, showed AR antagonistic activity and inhibited the survival and proliferation of AR-positive PCa cell lines. Molecular modelling revealed the binding mode and crucial interactions of this compound.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Alexis Paquin, Laurie Fortin, Julie Girouard, Carlos Reyes-Moreno, Irina F. Sevrioukova, Gervais Berube
Summary: The synthesis of a 17 alpha-linked C2-symmetric testosterone dimer and its dihydrotestosterone analog was achieved with a short reaction sequence and high overall yield. Both dimers showed antiproliferative activity on prostate cancer cell lines, with the testosterone dimer demonstrating greater potency. The testosterone dimer also exhibited stronger inhibition of drug-metabolizing enzyme CYP3A4 compared to the dihydrotestosterone dimer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Mingxiao Feng, Sara Divall, Dustin Jones, Vaibhave Ubba, Xiaomin Fu, Ling Yang, Hong Wang, Xiaofeng Yang, Sheng Wu
Summary: The study found that the androgen receptor in the liver does not play a role in the reproductive dysfunction induced by high androgen levels, while DHT-treated LivARKO female mice still experienced reproductive issues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yejin Kim, Dahae Lee, Hyejung Jo, Cheolhyeon Go, Jongwon Yang, Dongmin Kang, Jae Seung Kang
Summary: GV1001 effectively suppresses the proliferation of prostate cells, including stromal myofibroblasts and epithelial cells, by regulating cell growth and reducing hypertrophy. It also prevents prostatic fibrosis by inhibiting epithelial-mesenchymal transition through competing with testosterone for binding to androgen receptors, suggesting its potential as a therapeutic drug for BPH with fibrosis.
Article
Immunology
Murillo Duarte-Silva, Camilla N. S. Oliveira, Carlos Fuzo, Pedro V. Silva-Neto, Diana M. Toro, Vinicius E. Pimentel, Malena M. Perez, Thais F. C. Fraga-Silva, Jonatan C. S. Carvalho, Firmino M. S. Neto, Ronaldo B. M. Junior, Eurico Arruda, Fernando C. Vilar, Augusto M. Degiovani, Fatima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Gilberto G. Gaspar, Jose J. R. Rocha, Omar Feres, Ana P. M. Fernandes, Sandra R. Maruyama, Elisa M. S. Russo, Vania L. D. Bonato, Isabel K. F. M. Santos, Carlos A. Sorgi, Marcelo Dias-Baruffi, Lucia H. Faccioli, Cristina R. B. Cardoso
Summary: Sex differences are rarely addressed in disease management, but COVID-19 has shown a significant disparity, with higher mortality and severity in men. The role of androgens in COVID-19 is still debated. This study reveals the importance of androgens in the worsening of COVID-19 in men, highlighting the need for sex-specific disease management.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Endocrinology & Metabolism
Min Hu, Yuehui Zhang, Xin Li, Peng Cui, Amanda Nancy Sferruzzi-Perri, Mats Brannstrom, Linus R. Shao, Hakan Billig
Summary: Cytokine synthesis and increased endometrial inflammation in PCOS patients are associated with androgen-induced TLR4/IRF-7/NFκB signaling, which can be inhibited by metformin treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Peng Cui, Wei Hu, Tong Ma, Min Hu, Xiaoyu Tong, Feifei Zhang, Jiemei Shi, Xiaoqing Xu, Xin Li, Linus Ruijin Shao, Hakan Billig, Yi Feng
Summary: The study revealed that long-term androgen excess contributes to insulin resistance and hepatic steatosis in women with PCOS through affecting mitochondrial function and causing an imbalance in apoptosis and autophagy.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanling Wu, Belen Chanclon, Peter Micallef, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: The study demonstrates that elevated levels of adiponectin in utero can improve insulin sensitivity, reduce body weight and fat mass gain in adult offspring, and protect against PNA-induced visceral adiposity in the offspring.
Article
Obstetrics & Gynecology
X. Jiang, Q. Deng, E. Stener-Victorin
Summary: This study examined the genetic basis and causal relationship between polycystic ovary syndrome (PCOS) and a range of psychiatric disorders, finding no significant genetic correlation or causal relationship between them, despite some associations in certain contexts. While PCOS seems to be related to depression genetically, this effect may be mediated by BMI.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Min Hu, Yuehui Zhang, Lingjing Lu, Yu Zhou, Denghui Wu, Mats Brannstrom, Linus R. Shao, Hakan Billig
Summary: This study reveals that exposure to androgen and insulin triggers uterine ferroptotic signaling cascades in pregnant rats, while the addition of an anti-androgen increases the expression of ferroptosis-inhibitory proteins and reduces iron content. Furthermore, interactions between androgen receptor (AR) and NRF2 play a crucial role in regulating NRF2-targets in uterine ferroptosis.
Article
Pharmacology & Pharmacy
Emma Kay, Rouven Stulz, Cecile Becquart, Jelena Lovric, Carolina Tangemo, Aurelien Thomen, Dzenita Bazdarevic, Neda Najafinobar, Anders Dahlen, Anna Pielach, Julia Fernandez-Rodriguez, Roger Stromberg, Carina Ammala, Shalini Andersson, Michael Kurczy
Summary: Conjugating ASOs to GLP1 is an effective method to knock down targets in pancreatic beta-cells. The study found that ASOs separate from GLP1 relatively early in the endocytic pathway, and the stability of the conjugate may affect GLP1-ASO function.
Letter
Obstetrics & Gynecology
Hongxia Ma, Min Hu, Qidan Wen, Elisabet Stener-Victorin
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Man Mohan Shrestha, Sanne Wermelin, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: Adiponectin deficiency affects fetal growth and placental function, particularly in obese individuals. Low levels of adiponectin lead to placental dysfunction and increased fetal triglyceride load, which could have long-term effects on the offspring's metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Qianwen Liu, Bowen Tang, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang
Summary: The genetic link between type 2 diabetes, glycaemic traits and PCOS was found, influenced by both biological pleiotropy and causal mediation, some of which is independent of BMI. The study highlights the importance of controlling fasting insulin levels to mitigate the risk of PCOS, as well as screening for and monitoring type 2 diabetes in all women with PCOS, irrespective of BMI.
Article
Biochemistry & Molecular Biology
Min Hu, Yuehui Zhang, Yaxing Lu, Jing Han, Tingting Guo, Peng Cui, Mats Brannstrom, Linus R. Shao, Hakan Billig
Article
Biology
Yu Pei, Sanjiv Risal, Hong Jiang, Haojiang Lu, Eva Lindgren, Elisabet Stener-Victorin, Qiaolin Deng
Summary: Excessive androgen production and obesity play a key role in the development of polycystic ovary syndrome (PCOS). Various mouse models, including prenatal androgenized, peripubertal androgenized, overexpression of nerve growth factor in theca cells, and diet-induced maternal obesity, were used to study PCOS. Transcriptome analysis revealed differentially expressed genes in the hypothalamus, adipose tissue, ovary, and oocytes, with the ovaries and adipose tissues showing the most significant changes. The Ms4a6e gene, found in all mouse models and in women with PCOS, suggests a conserved disease function in PCOS.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tina Ronn, Alexander Perfilyev, Josefine Jonsson, Karl-Fredrik Eriksson, Sine W. Jorgensen, Charlotte Brons, Linn Gillberg, Allan Vaag, Elisabet Stener-Victorin, Charlotte Ling
Summary: This study found an association between DNA methylation levels in adipose tissue and circulating lipid levels, and identified novel epigenetic changes associated with lipid levels. These findings provide insights into the relationship between dysregulation of circulating lipids and epigenetic mechanisms in adipose tissue, and have important implications for the study of metabolic syndrome.
HUMAN MOLECULAR GENETICS
(2023)
Article
Pathology
Min Hu, Yuehui Zhang, Xu Zhang, Xiuying Zhang, Xinyue Huang, Yaxing Lu, Yijia Li, Mats Brannstrom, Amanda N. Sferruzzi-Perri, Linus R. Shao, Hakan Billig
Summary: This study found that polycystic ovary syndrome may increase pregnancy complications through impaired uterine spiral artery remodeling, placental dysfunction, and placental senescence.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Endocrinology & Metabolism
Meri Davitadze, Kashish Malhotra, Halimah Khalil, Meghnaa Hebbar, Chau Thien Tay, Aya Mousa, Helena PCOS SEva Team, Helena Teede, Leah Brennan, Elisabet Stener-Victorin, Punith Kempegowda
Summary: This systematic review and meta-analysis compared body image concerns among women with and without polycystic ovary syndrome (PCOS). The results showed that women with PCOS reported higher dissatisfaction with appearance evaluation and appearance orientation. They also had higher dissatisfaction with overweight preoccupation, lower body area satisfaction, and body weight classification compared to women without PCOS. These findings highlight the importance of addressing body image concerns in the clinical care of PCOS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Elisabet Stener-Victorin
Summary: Polycystic ovary syndrome (PCOS) is a complex disease affecting women of reproductive age, with unclear etiology. Animal models provide an important approach to study the pathophysiology, genetics, prevention, and treatment of PCOS.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)