Article
Endocrinology & Metabolism
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Summary: This study revealed a causal link between increased NPY-Y1 receptor gene expression in human T2D and beta-cell dysfunction and failure, indicating that the inhibition of the Y1 receptor may improve beta-cell function and protect beta-cell mass in T2D patients for better glycemic control.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Vittoria Favero, Arianna Cremaschi, Alberto Falchetti, Agostino Gaudio, Luigi Gennari, Alfredo Scillitani, Fabio Vescini, Valentina Morelli, Carmen Aresta, Iacopo Chiodini
Summary: Mild hypercortisolism (mHC) is characterized by excessive cortisol secretion without the typical symptoms of Cushing's syndrome, increasing the risk of various health issues. Testing cortisol levels after a 1 mg overnight dexamethasone suppression test is the preferred method of diagnosis, with surgery and medical therapy being common treatment options for patients with mHC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sydney A. Pascetta, Sarah M. Kirsh, Makenna Cameron, James Uniacke
Summary: In breast carcinomas, neuropeptide Y (NPY) acts on NPY1R and NPY5R, and their interaction is associated with enhanced migration and proliferation. Inhibiting NPY1R and NPY5R under hypoxia conditions greatly reduces signaling, proliferation, migration, invasion, and spheroid growth. In breast tumor tissue, NPY5R levels and colocalization with hypoxia correlate with advanced cancer, while NPY1R correlates with adverse outcomes.
Article
Agriculture, Dairy & Animal Science
Halima Abobaker, Nagmeldin A. Omer, Yun Hu, Abdulrahman A. Idriss, Ruqian Zhao
Summary: In this study, it was found that in ovo injection of betaine promotes adrenal glucocorticoid synthesis in chicken fetuses before hatching, which involves alterations in DNA methylation.
Article
Chemistry, Medicinal
Christoph Mueller, Jakob Gleixner, Maris-Johanna Tahk, Sergei Kopanchuk, Tonis Laasfeld, Michael Weinhart, Dieter Schollmeyer, Martin U. Betschart, Steffen Luedeke, Pierre Koch, Ago Rinken, Max Keller
Summary: The recent crystallization of the neuropeptide Y Y1 receptor(Y1R) in complex with the selective antagonist UR-MK299 has allowed for the design of novel fluorescent probes with high binding affinity and selectivity for Y1R.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Qiang Xu, Quanxu Chen, Liben Lin, Pu Zhang, Zengqiang Li, Yige Yu, Feifei Ma, Yingfen Ying, Xiaoheng Li, Ren-Shan Ge
Summary: Exposure to triadimefon during gestation may inhibit the development of fetal adrenal cortex in male fetuses, possibly due to the reduction of several proteins required for the synthesis of steroid hormones and changes in antioxidant contents, as well as alterations in the phosphorylation of AKT1, ERK1/2, and AMPK.
Article
Endocrinology & Metabolism
Yue Qi, Nicola J. Lee, Chi Kin Ip, Ronaldo Enriquez, Ramon Tasan, Lei Zhang, Herbert Herzog
Summary: This study investigates the role of neuropeptide Y (NPY) originating from Aguti-related protein (AGRP) neurons in feeding behavior and energy homeostasis. The results demonstrate that NPY from AGRP neurons is critical for initiating and continuously driving feeding. Additionally, this study identifies the specific Y-receptor pathways that control different aspects of energy homeostasis.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Chenxu Yan, Tianshu Zeng, Kailun Lee, Max Nobis, Kim Loh, Luoning Gou, Zefeng Xia, Zhongmin Gao, Mohammed Bensellam, Will Hughes, Jackie Lau, Lei Zhang, Chi Kin Ip, Ronaldo Enriquez, Hanyu Gao, Qiao-Ping Wang, Qi Wu, Jody J. Haigh, D. Ross Laybutt, Paul Timpson, Herbert Herzog, Yan-Chuan Shi
Summary: Blocking Y1 receptors in peripheral tissues using selective antagonists can reduce weight gain, decrease fat mass, and improve glucose metabolism, suggesting a potential safer and more effective treatment for diet-induced obesity.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Daniel P. Fudulu, George Horn, Georgina Hazell, Anne-Marie Lefrancois-Martinez, Antoine Martinez, Gianni D. Angelini, Stafford L. Lightman, Francesca Spiga
Summary: The hypothalamic-pituitary-adrenal axis is activated during periods of stress, such as critical illness, to re-establish homeostasis. Inflammation of the adrenal glands during critical illness may contribute to immune-adrenal communication and modulation of cortisol secretion. Studies show that inflammatory stimuli, like LPS, can affect the expression of adrenal steroidogenic enzymes and genes, with potential implications for clinical practice.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mariska A. M. Schroder, Adina F. Turcu, Patrick O'Day, Antonius E. van Herwaarden, Paul N. Span, Richard J. Auchus, Fred C. G. J. Sweep, Hedi L. Claahsen-van der Grinten
Summary: In males with classic 21-hydroxylase deficiency (21OHD), testicular adrenal rest tumors (TART) contribute to the androgen excess by producing 11oxC19 steroids at different proportions than the adrenals. The high ratio of 11 beta-hydroxytestosterone (11OHT) in the spermatic vein suggests the 11-hydroxylation of testosterone by TART, and in vitro results indicate that this metabolism is ACTH-sensitive.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Soo Hyun Kim, Gi Hoon Son, Joo Young Seok, Sung Kook Chun, Hwayoung Yun, Jaebong Jang, Young-Ger Suh, Kyungjin Kim, Jong-Wha Jung, Sooyoung Chung
Summary: This study developed a new class of small molecules that can inhibit cortisol production and suppress cholesterol synthesis through gene regulation. The findings provide a new pharmacological strategy for treating conditions such as Cushing's syndrome.
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Ran Nishioka, Mako Honda, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Fumio Otsuka
Summary: Orexins play important roles in sleep-wake regulation and food intake in the central nervous system. This study investigated the functions of orexin in adrenal steroidogenesis and its interaction with bone morphogenetic proteins (BMPs). The results suggest that both orexin and BMP-6 accelerate adrenocortical steroidogenesis in human adrenocortical cells, and these pathways mutually inhibit each other.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Eman Hassan, Shahinaz Magdy, Amany Attaallah, Eman Gaber, Omnia Mansour, Rehab A. Gomaa, Hala Odessy, Maria Augustyniak, Lamia M. El-Samad, Abeer El Wakil
Summary: This study aimed to evaluate the effect of silk sericin in alleviating steroidogenesis disorders induced by disturbed photoperiod. The results showed that sericin can reduce the impact of photoperiod disorders on testicular function, sex hormone levels, and sperm quantity and quality.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Bindu Chandrasekharan, Darra Boyer, Joshua A. Owens, Alexandra A. Wolfarth, Bejan J. Saeedi, Tanvi Dhere, Heba Iskandar, Andrew S. Neish
Summary: Selective blocking of NPY receptors using small molecule antagonists can attenuate intestinal inflammation by lowering TNF levels, suggesting a promising therapeutic value for NPY1R inhibition in alleviating inflammation in ulcerative colitis.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Neurosciences
Tyler S. Nelson, Bradley K. Taylor
Summary: In summary, the accelerating basic science literature reveals that spinal neuropeptide Y inhibits chronic pain by targeting the Y1 receptor, primarily located in key sites of pain transmission in the dorsal horn. Selective ablation of spinal Y1-INs attenuates hypersensitivity, while pharmacological activation of Y1 inhibits both pain and itch, suggesting Y1-INs as a promising therapeutic target for chronic pain and itch.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Chrysanthi Kouri, Grit Sommer, Christa E. Fluck
Summary: This paper discusses the possible oligogenic inheritance in individuals with differences of sex development (DSD), indicating that variations in common DSD genes may be associated with other related genes, implying a role of oligogenic inheritance in DSD.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Alexander Laemmle, Martin Poms, Bernadette Hsu, Mariia Borsuk, Veronique Rufenacht, Joshua Robinson, Martin C. Sadowski, Jean-Marc Nuoffer, Johannes Haberle, Holger Willenbring
Summary: The study identified the critical role of AQP9 in functional urea metabolism and successfully established an in vitro liver disease model of OTCD using hiPSC-Heps. By manipulating hiPSC-Heps, OTC activity and ureagenesis could be corrected, potentially improving the therapy of OTCD through genotype/phenotype correlation and drug screens.
Editorial Material
Endocrinology & Metabolism
Tulay Guran, Christa E. Fluck
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Tobias Troger, Grit Sommer, Mariarosaria Lang-Muritano, Daniel Konrad, Beatrice Kuhlmann, Urs Zumsteg, Christa E. Fluck
Summary: This study analyzed the impact of growth during adrenarche on the final height of adequately treated classic CAH patients. The results showed that patients with accelerating bone age during adrenarche were taller than the normal population, but their predicted adult height was lower compared to nonaccelerating patients. However, when reassessed during puberty, both groups showed similar (predicted) final height.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Esmeralda Nava, Britta Hartmann, Larissa Boxheimer, Andrea Capone Mori, Jean-Marc Nuoffer, Yelena Sargsyan, Sven Thoms, Hendrik Rosewich, Eugen Boltshauser
Summary: We present a case of PEX10-related cerebellar ataxia and analyze 14 similar patients. The measurement of phytanic acid and VLCFA ratios is important for diagnosis, especially in patients with early onset and mild symptoms.
Article
Clinical Neurology
Markus Gschwind, Nuria Garcia Segarra, Andre Schaller, Ramona Bolognini, Jean-Marc Nuoffer, Raphael Hourez, Manuel Deprez, Benoit Lhermitte, Philippe Maeder, Christel Tran, Thierry Kuntzer
Summary: This article presents a patient with spastic paraplegia and ataxia, which lasted for 40 years and eventually led to death due to postinfectious lactic acidosis. Various diagnostic methods revealed the patient had a biallelic variant of the NDUFV1 gene, causing necrotizing leukoencephalomyelopathy. This case extends the understanding of NDUFV1 variants and highlights the need for awareness of respiratory chain diseases in adult patients with sudden deteriorating neurological deficits.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haibin Deng, Yanyun Gao, Verdiana Trappetti, Damian Hertig, Darya Karatkevich, Tereza Losmanova, Christian Urzi, Huixiang Ge, Gerrit Adriaan Geest, Remy Bruggmann, Valentin Djonov, Jean-Marc Nuoffer, Peter Vermathen, Nicola Zamboni, Carsten Riether, Adrian Ochsenbein, Ren-Wang Peng, Gregor Jan Kocher, Ralph Alexander Schmid, Patrick Dorn, Thomas Michael Marti
Summary: The study reveals the crucial role of lactate dehydrogenase B (LDHB) in regulating glucose and mitochondrial metabolism, and its impact on the survival and proliferation of non-small cell lung cancer (NSCLC) cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christian Urzi, Damian Hertig, Christoph Meyer, Sally Maddah, Jean-Marc Nuoffer, Peter Vermathen
Summary: This study demonstrates the potential of using NMR technology to measure intracellular and extracellular metabolite concentrations in living cells, as well as to distinguish between them. The results show that the method is reliable and sensitive in detecting concentration changes of metabolites in intra- and extracellular compartments under different culture media conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Michelle J. J. Dennig, Grit Sommer, Tanja Zingg, Christa E. E. Flueck, Claudia Boettcher
Summary: This study evaluated metabolic control in children and adolescents with type 1 diabetes and found that many patients failed to reach treatment goals. Factors such as insulin pump use, parents coming from Western European countries, and shorter duration of diabetes were associated with better metabolic control. Age, diabetes technology use, and native language influenced the frequency of healthcare contacts.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Endocrinology & Metabolism
Christa E. Flueck, Tanja Kuiri-Hanninen, Sanna Silvennoinen, Ulla Sankilampi, Michael Groessl
Summary: Fetal adrenal involution occurs around term-equivalent age in preterm infants and is not triggered by premature birth. Testosterone levels are higher in preterm infants at birth and decline slower until term compared to full-term babies. Premature infants have lower levels of dihydrotestosterone and lower activity in the classic androgen biosynthesis pathway, but no difference was found in the activity of the alternate backdoor pathway.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Nikolas Boy, Chris Muehlhausen, Esther M. Maier, Diana Ballhausen, Matthias R. Baumgartner, Skadi Beblo, Peter Burgard, Kimberly A. Chapman, Dries Dobbelaere, Jana Heringer-Seifert, Sandra Fleissner, Karina Grohmann-Held, Gabriele Hahn, Inga Harting, Georg F. Hoffmann, Frank Jochum, Daniela Karall, Vassiliki Konstantopoulous, Michael B. Krawinkel, Martin Lindner, E. M. Charlotte Maertner, Jean-Marc Nuoffer, Jurgen G. Okun, Barbara Plecko, Roland Posset, Katja Sahm, Sabine Scholl-Buergi, Eva Thimm, Magdalena Walter, Monique Williams, Stephan Vom Dahl, Athanasia Ziagaki, Johannes Zschocke, Stefan Koelker
Summary: Glutaric aciduria type 1 is a rare neurometabolic disorder caused by gene variations in GCDH, leading to the accumulation of acid substances and subsequent neurological damage. Early screening and metabolic treatment can improve the neurological outcome of patients.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Review
Endocrinology & Metabolism
Emanuele Pignatti, Therina du Toit, Christa E. Flueck
Summary: The adrenal cortex undergoes multiple structural and functional rearrangements to meet the systemic needs for steroids during different stages of life. Its proper subdivision into distinct functional zones from embryonic stages to adulthood depends on a fine-tuned gene network. The steroidogenic activity of the fetal adrenal plays a crucial role in maintaining normal fetal development and growth.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Nicolas Melin, Tural Yarahmadov, Daniel Sanchez-Taltavull, Fabienne E. Birrer, Tess M. Brodie, Benoit Petit, Andrea Felser, Jean-Marc Nuoffer, Matteo Montani, Marie-Catherine Vozenin, Evelyn Herrmann, Daniel Candinas, Daniel M. Aebersold, Deborah Stroka
Summary: The study established a mouse model of radiation-induced liver fibrosis and found that irradiation-induced mitochondrial DNA instability contributes to the development of fibrosis via the generation of excessive reactive oxygen species, p53 pathway activation, and a senescence-like phenotype.
Article
Endocrinology & Metabolism
Benjamin P. Magyar, Maristella Santi, Grit Sommer, Jean-Marc Nuoffer, Alexander Leichtle, Michael Groessl, Christa E. Fluck
Summary: Significant changes in steroid metabolism occurred after 48 hours of fasting in healthy women. In contrast to metabolic changes seen at baseline in PCOS women compared to healthy women, and after starving of steroidogenic cells, no androgen excess was observed after short-term fasting in healthy young women.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
