Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 315, Issue 1-2, Pages 11-18Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.10.015
Keywords
Endocrine pancreas development; Arx; Pax4; Mouse; Diabetes; Fate specification
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Funding
- Max-Planck Society
- Dr. H. Storz and Alte Leipziger foundation
- Juvenile Diabetes Research foundation [26-2008-639]
- INSERM AVENIR program
- INSERM
- NIH Beta Cell Biology Consortium [U19 DK 072495-01]
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Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therapies, alternative treatments need to be established. In order to compensate the beta-cell deficiency associated with type 1 diabetes, current research focuses on new strategies to generate insulin-producing beta-cells for transplantation purpose, including the differentiation of stem or progenitor cells, as well as the trans-differentiation of dispensable mature cell types. However, to successfully force specific cells to adopt a functional beta-cell fate or phenotype, a better understanding of the molecular mechanisms underlying beta-cell genesis is required. The present short review summarizes the hitherto known functions and interplays of several key factors involved in the development of the different endocrine cell lineages during pancreas morphogenesis, as well as their potential to direct the generation of beta-cells. Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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