Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 300, Issue 1-2, Pages 132-136Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.09.026
Keywords
Arcuate nucleus (ARC); Cannabinoid receptor 1 (CB1R); Central nervous system (CNS); Dorsomedial hypothalamic nucleus (DMH); Knockout (KO); Steroidogenic factor 1 (SF-1); Ventromedial hypothalamic nucleus (VMH)
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Funding
- NIDDK NIH HHS [1RL1DK081185-01, DK54480] Funding Source: Medline
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Steroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamus-pituitary-steroidogenic organ axis. Global knockout studies in mice revealed the essential in vivo roles of SF-1 in the ventromedial hypothalamic (VMH) nucleus, adrenal glands, and gonads. One limitation of global SF-1 knockout mice is their early postnatal death from adrenocortical insufficiency. To overcome limitations of the global knockout mice and to delineate the roles of SF-1 in the brain, we used Cre/loxP recombination technology to genetically ablate SF-1 specifically in the central nervous system (CNS). Mice with CNS-specific knockout of SF-1 mediated by nestin-Cre showed increased anxiety-like behavior, revealing a crucial role of SF-1 in a complex behavioral phenotype. Our studies with CNS-specific SF-1 KO mice also defined roles of SF-1 in regulating the VMH expression of target genes implicated in anxiety and energy homeostasis. Therefore, this review will focus on our recent studies defining the functional roles of SF-1 in the VMH linked to anxiety and energy homeostasis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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