Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 282, Issue 1-2, Pages 12-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2007.11.018
Keywords
meiosis; small GTPases; mouse; oocyte
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Meiotic divisions during oogenesis in higher eukaryotes are extremely asymmetric giving rise to one gamete, the oocyte, and two polar bodies. In most species, this asymmetric partitioning relies on the eccentric positioning of meiotic spindles. Recent work performed in mouse and frog oocytes has suggested the involvement of small GTPases, such as Cdc42, Rac and Ran both in the control of spindle organization and positioning. The present review summarizes these findings that shed tight on the molecular mechanisms by which small GTPases control asymmetric cell divisions in vertebrate oocytes. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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