Phosphoinositide-Dependent Kinase 1 and mTORC2 Synergistically Maintain Postnatal Heart Growth and Heart Function in Mice

Cardiovascular science: opportunities for translating research into improved care

(2013) Eugene Braunwald   JOURNAL OF CLINICAL INVESTIGATION

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

(2013) Yi Zhu et al.   PLoS One

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

(2011) Ruomin Di et al.   BIOCHEMICAL JOURNAL

I B kinase   and TANK-binding kinase 1 activate AKT by direct phosphorylation

(2011) X. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction

(2010) Kyle T. Keyes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation

(2010) Zai Chang et al.   DEVELOPMENTAL BIOLOGY

Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals

(2010) Ray E Hershberger et al.   GENETICS IN MEDICINE

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development

(2010) Q. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

(2010) Adam S. Lazorchak et al.   MOLECULAR CELL

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK1 coordinates survival pathways and  -adrenergic response in the heart

(2009) K. Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

(2008) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

Insulin signalling in the heart

(2008) L. Bertrand et al.   CARDIOVASCULAR RESEARCH

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

(2008) Wei–Qi He et al.   GASTROENTEROLOGY

Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury

(2008) Hongmei Ruan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY