Article
Multidisciplinary Sciences
Alexandra Born, Janne Soetbeer, Morkos A. Henen, Frauke Breitgoff, Yevhen Polyhach, Gunnar Jeschke, Beat Voegeli
Summary: Pin1 is a cell regulator with two domains. Ligand binding can change the conformation of these domains, thus affecting its catalytic site.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Liqun Zhao, Steven H. Fong, Qiaoyun Yang, Yun-Jin Jiang, Vladimir Korzh, Yih-Cherng Liou
Summary: This study demonstrates that Pin1 plays a crucial role in regulating NeuroD protein levels during neuronal specification, highlighting its functional importance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samia Bedouhene, Min Liu, Nassima Senani, Tarek Boussetta, Coralie Pintard, Pham My-Chan Dang, Jamel El-Benna
Summary: Neutrophils are important cells in the innate immune and inflammatory responses, but excessive activation can lead to tissue injury. The enzyme Pin1 plays a crucial role in neutrophil functions, and inhibiting its activity can affect the inflammatory response of neutrophils.
Article
Endocrinology & Metabolism
Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
Summary: Deleting the Pin1 gene in epiWAT promotes lipolysis and increases ATGL protein expression. Pin1 directly associates with ATGL, enhancing its degradation through the ubiquitin proteasome system. AdipoPin1 KO mice under a high fat diet exhibit higher lipolytic activity and improved glucose metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cell Biology
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Summary: Notch signaling is crucial in tumorigenesis and its response is regulated by the hydroxylation and deubiquitination of NICD, which is disrupted under hypoxic conditions.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Yew Mun Lee, Deryn En-Jie Teoh, Kay Yeung, Yih-Cherng Liou
Summary: Pin1 plays a crucial role in various diseases, particularly in neurodegenerative diseases and cancer. Its conservation across different species highlights its importance, and using different Pin1 models may provide insights for disease therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ting Wang, Wan-Yi Hsiao, Shao-Win Wang
Summary: Pin1 regulates the structure and function of eukaryotic RNA polymerase II through interaction with Rpb1 in response to oxidative stress, facilitating transcription elongation. Elevated Pin1 levels in cancer cells may help sustain survival under oxidative stress. These findings suggest a conserved function of Pin1 in cellular response to oxidative stress among eukaryotic cells with potential clinical implications.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Nikhil Ponnoor Anto, Amitha Muraleedharan, Pulak Ranjan Nath, Zuoming Sun, Chen Keasar, Etta Livneh, Alex Braiman, Amnon Altman, Kok-Fai Kong, Noah Isakov
Summary: Protein kinase C-α (PKC-α) is selectively expressed in T lymphocytes and plays a crucial role in T cell activation and proliferation. The phosphorylation of Thr(335)-Pro residue in the regulatory domain of PKC-α is important for its activation and localization at the immunological synapse. The peptidyl-prolyl cis-trans isomerase Pin1 interacts with PKC-α through the phosphorylated Thr(335)-Pro motif, and this interaction is involved in early activation events in TCR-triggered T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenda Wu, Xuezhen Xue, Yan Chen, Ning Zheng, Jichuang Wang
Summary: The article summarizes the functions and mechanisms of the prolyl isomerase Pin1 in the therapeutic resistance of various cancers, discussing its relationship with tumor resistance and the important role and mechanism in cancer therapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Yanzhuo Zhang, Zhe Lv, Yudong Liu, Huan Cao, Jianwang Yang, Baoshan Wang
Summary: PIN1 plays a crucial role in protecting hair cells and HEI-OC1 cells from senescence, with its protein level decreasing in the serum of ARHL patients and tissues of aged mice. Overexpression of PIN1 can reverse p53 activation and rescue cells from senescence.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Medical Laboratory Technology
James S. Malter
Summary: Alzheimer's disease is a significant and escalating public health crisis. Despite extensive research over the past century, its causes remain elusive and current therapies are ineffective. However, recent studies have shed light on the critical role of dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, in the pathogenesis of Alzheimer's disease.
TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Haneui Bae, Jeff Coller
Summary: Translation by the ribosome is the final step in the process of producing proteins from DNA. Recent research has shown that the ribosome also plays a role in controlling mRNA stability and degradation. The rate at which the ribosome moves along the mRNA molecule affects the stability of the transcript. This process is influenced by the codon sequence, with some codons causing the ribosome to pause and adopt a specific conformation that triggers mRNA degradation. These findings suggest that the coding region of mRNA not only determines protein content, but also impacts protein levels by influencing the fate of the transcript.
Article
Cell Biology
Jennifer Michelle Potter-Birriel, Graydon B. Gonsalvez, William F. Marzluff
Summary: Replication-dependent histone mRNAs, unique in their lack of polyadenylation, play a crucial role in Drosophila oogenesis. The presence of a high concentration of SLBP in the nucleus of stage 10B oocytes is essential for histone gene transcription, as revealed in this study.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Jianjian Yu, Dan Hu, Laicheng Wang, Zongcheng Fan, Changsheng Xu, Yunchai Lin, Xin Chen, Jinxiu Lin, Feng Peng
Summary: This study found that diabetes is a potential risk factor for gastric cancer. The Pin1/BRD4 axis plays an important role in hyperglycemia-induced proliferation and migration of gastric cancer cells. Inhibition of Pin1 and BRD4 can significantly suppress high-glucose-induced proliferation and migration of gastric cancer cells, leading to improved prognosis for patients.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiro Koikawa, Shin Kibe, Futoshi Suizu, Nobufumi Sekino, Nami Kim, Theresa D. Manz, Benika J. Pinch, Dipikaa Akshinthala, Ana Verma, Giorgio Gaglia, Yutaka Nezu, Shizhong Ke, Chenxi Qiu, Kenoki Ohuchida, Yoshinao Oda, Tae Ho Lee, Babara Wegiel, John G. Clohessy, Nir London, Sandro Santagata, Gerburg M. Wulf, Manuel Hidalgo, Senthil K. Muthuswamy, Masafumi Nakamura, Nathanael S. Gray, Xiao Zhen Zhou, Kun Ping Lu
Summary: Upregulation of Pin1 in PDAC contributes to the desmoplastic and immunosuppressive TME, but targeting Pin1 with available drugs can synergize with immunotherapy and gemcitabine to induce complete elimination of PDAC.