Review
Cell Biology
Alex Willems, Lieven De Veylder
Summary: The review focuses on the plant APC/C complex, discussing its importance in plant development and its association with different developmental processes. The interactions between plant-specific APC/C activator subunits and other subunits are also described. Finally, a comprehensive list of confirmed and suspected plant APC/C target proteins is provided, offering opportunities to manipulate APC/C activity for increased crop yield and improved resilience to climate change.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Shuang Bai, Li Sun, Xi Wang, Shuang-Min Wang, Zhou-Qing Luo, Yamei Wang, Quan-Wen Jin
Summary: This study reveals that the timely silencing of the activated spindle assembly checkpoint (SAC) in fission yeast requires participation of the dnt1 gene. Lack of the dnt1 gene leads to increased sensitivity to thiabendazole and higher rate of lagging chromosomes. The absence of Dnt1 prolongs the inhibitory binding of mitotic checkpoint complex (MCC) to APC/C and slows down the degradation of cyclin B and securin, resulting in delayed entry into anaphase.
Article
Oncology
Owen J. Chen, Ester Castellsague, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik Schneider, Morten Hillmer, Susanne Bens, Reiner Siebert, Colin J. R. Stewart, Ziguo Zhang, William C. H. Chao, Celia M. T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
Summary: Two germline CDC20 missense variants that segregate with cancer in two families compromise the spindle assembly checkpoint and lead to aberrant mitotic progression, which could predispose cells to transformation.
Review
Biochemistry & Molecular Biology
Scott C. Schuyler, Hsin-Yu Chen
Summary: Research on budding yeast Saccharomyces cerevisiae has provided important insights into highly conserved biological pathways, particularly in relation to the mitotic cell cycle and cell cycle checkpoints. Understanding these mechanisms has led to the development of potential drug targets for cancer treatment, such as specific regions in the APC/C subunits and Cdc20, to potentially inhibit mitotic slippage in cancer cells resistant to mitotic poisons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Rajib Bhuniya, Xinrui Yuan, Longchuan Bai, Kathryn L. Howie, Rui Wang, Wei Li, Frank Park, Chao-Yie Yang
Summary: CDC20 overexpression is associated with poor prognosis in breast and other cancers. By designing new CDC20 inhibitors and improving their chemical structure, the antitumor activity can be enhanced. The most effective inhibitor, 22, shows promise for further development.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Fabin Dang, Li Nie, Wenyi Wei
Summary: Cell cycle progression relies on the activation of cyclin-dependent kinases, regulated in part by ubiquitin-mediated proteolysis. Dysregulated proteolytic control can lead to uncontrolled cell proliferation and tumorigenesis. Targeting E3 ubiquitin ligases involved in cell cycle regulation may offer novel therapeutic strategies for cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Christopher Thomas, Benjamin Wetherall, Mark D. Levasseur, Rebecca J. Harris, Scott T. Kerridge, Jonathan M. G. Higgins, Owen R. Davies, Suzanne Madgwick
Summary: The study reveals an excess of securin over separase in mouse oocytes during meiosis I, with a mechanism promoting securin destruction in prometaphase I. This destruction mechanism relies on specific residues within securin that are exposed when not bound to separase. The authors suggest that this mechanism is crucial for successful meiotic progression in mouse oocytes by ensuring the removal of non-separase-bound securin before metaphase.
NATURE COMMUNICATIONS
(2021)
Review
Genetics & Heredity
Nafees Ahamad, Saman Khan, Alaa Taha A. Mahdi, Yong-jie Xu
Summary: The DNA replication checkpoint is activated in response to perturbed replication, with RecQ helicases playing various roles in this process. These helicases are conserved from bacteria to yeasts and humans, suggesting their importance in maintaining genomic integrity and cell survival.
Article
Biotechnology & Applied Microbiology
Xiaolin Zhang, Fang Wen, Zhenyu Xu, Deying Sun, Wee Chew, Jianhua Liu
JOURNAL OF APPLIED PHYCOLOGY
(2019)
Article
Plant Sciences
Yinjia Li, Sheng Zuo, Zhiliang Zhang, Zhanjie Li, Jinlei Han, Zhaoqing Chu, Robert Hasterok, Kai Wang
Article
Biotechnology & Applied Microbiology
Jibei Liang, Tao Cheng, Yi Huang, Jianhua Liu
Article
Multidisciplinary Sciences
Min Jiang, Chao Niu, Jianmei Cao, Di-an Ni, Zhaoqing Chu
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Yu Yang, Kai Tang, Tatsiana U. Datsenka, Wenshan Liu, Suhui Lv, Zhaobo Lang, Xingang Wang, Jinghui Gao, Wei Wang, Wenfeng Nie, Zhaoqing Chu, Heng Zhang, Avtar K. Handa, Jian-Kang Zhu, Huiming Zhang
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Xingcui Hu, Tao Cheng, Jianhua Liu
Article
Marine & Freshwater Biology
Qing-Ling Zhu, Sai-Nan Guo, Fang Wen, Xiao-Lin Zhang, Cheng-Cheng Wang, Lan-Fang Si, Jia-Lang Zheng, Jianhua Liu
AQUATIC TOXICOLOGY
(2019)
Article
Multidisciplinary Sciences
Jibei Liang, Fang Wen, Jianhua Liu
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Wei Wang, Sunil Kumar Singh, Xiwen Li, Hui Sun, Yu Yang, Min Jiang, Hailing Zi, Renyi Liu, Huiming Zhang, Zhaoqing Chu
Article
Marine & Freshwater Biology
Qing-Ling Zhe, Jia-Lang Zheng, Jianhua Liu
AQUATIC TOXICOLOGY
(2020)
Article
Marine & Freshwater Biology
Qing-Ling Zhu, Jingjing Bao, Jianhua Liu, Jia-Lang Zheng
AQUATIC TOXICOLOGY
(2020)
Article
Environmental Sciences
Qingling Zhu, Mengmeng Zhang, Jingjing Bao, Jianhua Liu
Summary: The study reveals that D. salina maintains cellular defense against high cadmium concentration by upregulating ROS-scavenging activities. Additionally, cells produce oxidants and antioxidants through multiple pathways to maintain dynamic redox homeostasis under extended exposure to cadmium.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Qingling Zhu, Mengmeng Zhang, Bingying Liu, Fang Wen, Zhili Yang, Jianhua Liu
Summary: Under mixotrophic growth conditions, high glucose supplementation promotes growth and cell biomass production in Chlorella sorokiniana G32, while photosynthetic efficiency and glucose conversion rate are affected. Transcriptomic and metabolomic analyses reveal the regulatory mechanisms of glucose assimilation and energy metabolism in G32 under mixotrophic conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhili Yang, Zengping Zhang, Jiaqi Zhu, Yunhao Ma, Jianxin Wang, Jianhua Liu
Summary: This study presents a three-step protocol for constructing conditional lethal allele of essential genes in Pseudomonas aeruginosa. Using PA0006 as an example, the plasmid-based PA0006(Ts) mutant exhibited defects in regulation of cell morphology, formation of intact core LPS, and attachment of the O-antigen at restrictive temperatures but not at permissive temperatures. A suppressor of PA0006(Ts) was isolated through spontaneous mutations and showed restored cell morphology but not core oligosaccharide or O-antigen. This method should be widely applicable for phenotype and suppressibility analyses of other essential genes of interest in P. aeruginosa.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Juan Ignacio Vilchez, Qiming Tang, Richa Kaushal, Wei Wang, Suhui Lv, Danxia He, Zhaoqing Chu, Heng Zhang, Renyi Liu, Huiming Zhang
GENOME ANNOUNCEMENTS
(2018)