Article
Medicine, Research & Experimental
Claudia Morais Sequeira, Marcela Anjos Martins, Renata Alves, Ana Lucia Rosa Nascimento, Giuly Cristina Rodrigues Mello Botti, Vinicius Novaes Rocha, Cristiane Matsuura
Summary: The study demonstrated that aerobic exercise training could effectively prevent doxorubicin-induced cardiomyopathy and preserve cardiomyocyte ultrastructure, partially through activation of the physiological protein synthesis pathway and reduction of oxidative stress.
Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Review
Biochemistry & Molecular Biology
Scott K. Powers, Erica Goldstein, Matthew Schrager, Li Li Ji
Summary: The association between muscular exercise and oxidative stress in humans was first reported over 45 years ago. It was discovered that contracting skeletal muscles produce oxidants capable of oxidizing cellular biomolecules. Exercise training increases the expression of antioxidant enzymes in muscles, which protect against exercise-induced oxidative damage.
Article
Multidisciplinary Sciences
Calvin P. Philp, Nathan W. Pitchford, Denis C. Visentin, Cecilia M. Kitic, James W. Fell, Martin Buchheit, Christopher T. Minson, John R. Gregory, Greig Watson
Summary: This study investigated the effects of heat acclimation on rowing performance in national-level rowers. The results showed that a 10-session heat acclimation intervention improved various performance indicators, such as tympanic temperature, perceived exertion, and sweat loss, as well as physiological parameters like plasma volume and respiratory exchange ratio. These findings suggest that heat acclimation can enhance rowing performance in temperate conditions for high-level rowers.
Article
Biology
Olina Dudasova Petrovicova, Ivan Stankovic, Neda Milinkovic, Violeta Dopsaj, Brizita Dordevic, Milivoj Dopsaj
Summary: This study investigated the effects of supplementation with plant origin superoxide dismutase on muscle damage, metabolism, and work performance in rowers. The results showed that the supplement reduced levels of creatine kinase and interleukin-6, and improved rowing performance.
Review
Cell Biology
Joshua Denham
Summary: Telomerase plays a crucial role in maintaining genomic integrity by protecting and preserving telomeres. It has canonical functions in cancer and cell development while also exerting critical extra-telomeric functions. Activation of telomerase has therapeutic potential for aging-related diseases. Exercise can influence telomerase and holds promise for modulating its activity. Future research should focus on understanding the underlying cell signaling mechanisms.
Article
Cell Biology
Luiz Alexandre Medrado de Barcellos, William Antonio Goncalves, Marcos Paulo Esteves de Oliveira, Juliana Bohnen Guimaraes, Celso Martins Queiroz-Junior, Carolina Braga de Resende, Remo Castro Russo, Candido Celso Coimbra, Albena Nunes Silva, Mauro Martins Teixeira, Barbara Maximino Rezende, Vanessa Pinho
Summary: Acute high intensity exercise induces inflammation, but physical training can attenuate exercise-induced inflammation. Training enhances immune adaptations and decreases inflammatory response post-exercise.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tim J. M. Wallis, Magdalena Minnion, Anna Freeman, Andrew Bates, James M. Otto, Stephen A. Wootton, Sophie V. Fletcher, Michael P. W. Grocott, Martin Feelisch, Mark G. Jones, Sandy Jack
Summary: A study found that individualized aerobic interval training can improve exercise capacity and redox status in idiopathic pulmonary fibrosis (IPF) patients. After an 8-week training program, patients showed significant improvements in exercise capacity and redox status.
Article
Sport Sciences
Jason P. Pitt, Richard M. Bracken, S. N. Scott, Federico Y. Fontana, Kristina Skroce, Olivia McCarthy
Summary: This study compared the in-ride nutritional practices of professional cyclists with type 1 diabetes during training and racing conditions and found that energy intake and carbohydrate consumption were similar. The time spent within the euglycemic range was also similar.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Multidisciplinary Sciences
Robin Schaefer, Hendrik Schaefer, Petra Platen
Summary: This study suggests that perturbation-based trunk stabilization training may be effective in improving the physical function of the lower back in elite rowers. There were similar decreases in pain intensity in both the PTT group and the control group.
Editorial Material
Hematology
Laurent A. Messonnier
Summary: Although sickle cell disease (SCD) is related to a single point mutation, there is extreme variability in the clinical presentation among patients. Genetic variants may contribute to this variability. In this study, Dosunmu-Ogunbi et al. highlighted the importance of a genetic variant affecting mitochondrial function in the cardiovascular pathophysiology of SCD. Their findings provide important insights and perspectives for patient management.
Article
Biochemistry & Molecular Biology
Anna Freeman, Doriana Cellura, Magdalena Minnion, Bernadette O. Fernandez, Cosma Mirella Spalluto, Denny Levett, Andrew Bates, Timothy Wallis, Alastair Watson, Sandy Jack, Karl J. Staples, Michael P. W. Grocott, Martin Feelisch, Tom M. A. Wilkinson
Summary: This study showed that personalized exercise intervention in asthma patients can improve symptoms, lung inflammation, physical fitness, and overall quality of life. Exercise also led to increased antioxidant capacity, improved lung function, reduced airway hyperreactivity, and decreased eosinophilic inflammation in the participants.
Article
Medicine, Research & Experimental
Samaneh Akbar Gharehbagh, Javad Tolouei Azar, Mazdak Razi
Summary: Exercise training has significant impacts on testicular antioxidant and metabolic potentials. High-intensity training can suppress antioxidant biomarkers while increasing autophagy-inducers expression, while low and moderate intensity training may help maintain metabolic homeostasis and promote spermatogenesis differentiation.
Article
Medicine, Research & Experimental
Ghorbannejad Hadi, Tofighi Asghar, Tolouei Azar Javad, Razi Mazdak
Summary: Long-term consumption of tramadol negatively affects spermatogenesis development, while exercise training protocols (ETPs) can reduce the damage caused by tramadol on antioxidant and endocrine capacities, with low-intensity training showing the best results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Brisamar Estebanez, Nishant P. Visavadiya, Jose E. Vargas, Marta Rivera-Viloria, Andy Khamoui, Jose A. de Paz, Chun-Jung Huang
Summary: Resistance training can improve endoplasmic reticulum stress response in elderly individuals, according to this study.
Article
Biology
Nikola Tatalovic, Teodora Vidonja Uzelac, Milica Mijovic, Gordana Kozelj, Aleksandra Nikolic-Kokic, Zorana Orescanin Dusic, Mara Bresjanac, Dusko Blagojevic
Summary: Ibogaine induces rapid changes in cellular energetics and antioxidant activities, with a sex-specific effect at the level of antioxidant cellular system. The drug shows specific effects in rats that are gender- and tissue-dependent, as well as dose- and time-dependent.
Article
Cell Biology
Nevena D. Draginic, Vladimir L. Jakovljevic, Jovana N. Jeremic, Ivan M. Srejovic, Marijana M. Andjic, Marina R. Rankovic, Jasmina Z. Sretenovic, Vladimir Zivkovic, Biljana T. Ljujic, Slobodanka L. Mitrovic, Stefani S. Bolevich, Sergey B. Bolevich, Isidora M. Milosavljevic
Summary: This study investigates the potential of Melissa officinalis extracts (MOEs) to prevent the development of myocarditis and ameliorate the severity of experimental autoimmune myocarditis (EAM). The results show that MOEs improve cardiac function, reduce inflammation and collagen content, and decrease oxidative stress. Therefore, MOEs may be considered as an adjuvant therapy for patients with autoimmune myocarditis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Cell Biology
Marija Medovic, Vladimir Lj Jakovljevic, Vladimir Zivkovic, Nevena S. Jeremic, Jovana N. Jeremic, Sergey B. Bolevich, Ana B. Ravic Nikolic, Vesna M. Milicic, Ivan M. Srejovic
Summary: Psoriasis is a chronic immune-mediated disease with an unknown precise etiology. Oxidative stress and aberrant immune response play important roles in the pathogenesis of psoriasis. The complex immune pathways of both the innate and adaptive immune systems are closely related to the development of psoriasis. Oxidative stress also contributes to the pathophysiology of the disease. The immune model of psoriasis suggests that the immune system is activated in susceptible individuals by environmental factors and loses immune tolerance to psoriasis autoantigens. Various cytokines, including IL-17, have been found to play important roles in the development of psoriasis. Oxidative stress can promote inflammation through different signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Medicine, General & Internal
Nebojsa Tasic, Danijela Tasic, Zorana Kovacevic, Marko Filipovic, Milan Arsic, Sladjana Bozovic-Ogarevic, Biljana Despotovic, Milovan Bojic, Zlatko Maksimovic, Nebojsa Zdravkovic, Sara Mijailovic, Vladimir Zivkovic, Tamara Nikolic Turnic, Vladimir Jakovljevic
Summary: The study found that home and office blood pressure monitoring methods have a significant impact on the adjustment of antihypertensive treatment in hypertensive patients. Home blood pressure telemonitoring can be an excellent alternative for blood pressure assessment, especially in patients with diabetes and dyslipidemia.
Article
Biochemistry & Molecular Biology
Danica Tasic, Milos Opacic, Sanja Kovacevic, Aleksandra Nikolic Kokic, Milena Dimitrijevic, Dusan Nikolic, Danijela Vojnovic Milutinovic, Dusko Blagojevic, Ana Djordjevic, Jelena Brkljacic
Summary: The effects of a fructose-rich diet and chronic stress on copper metabolism in the kidneys are still understudied. This study found that fructose, independent of stress, decreased renal copper level and modulated renal copper metabolism to preserve vital cellular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksandar Juskovic, Marina Nikolic, Biljana Ljujic, Aleksandar Matic, Vladimir Zivkovic, Ksenija Vucicevic, Zoran Milosavljevic, Radisa Vojinovic, Nemanja Jovicic, Suzana Zivanovic, Nevena Milivojevic, Vladimir Jakovljevic, Sergey Bolevich, Marina Miletic Kovacevic
Summary: This study explores the efficacy of combined treatment with allogeneic adipose-derived mesenchymal stem cells (ADMSCs) and hyperbaric oxygenation treatment (HBO) in a rat osteoarthritis (OA) model. The results show that the combination therapy significantly improves cartilage regeneration in the knee joint, reduces joint damage, and alleviates inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dusan Todorovic, Marija Stojanovic, Kristina Gopcevic, Ana Medic, Sanja Stankovic, Boba Kotlica, Milica Labudovic Borovic, Dragan Djuric
Summary: This study aimed to investigate the effects of hyperhomocysteinemia and aerobic physical activity on cardiovascular biomarkers, oxidative stress, and histomorphometric parameters in the heart and aorta of rats. The results showed that aerobic physical activity in hyperhomocysteinemic rats led to increased oxidative stress in cardiac tissue, changes in histomorphometric parameters, and elevated lipid parameters and cardiac damage biomarkers in sera.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Miona Vuletic, Vladimir Jakovljevic, Suzana Zivanovic, Milos Papic, Mirjana Papic, Rasa Mladenovic, Vladimir Zivkovic, Ivan Srejovic, Jovana Jeremic, Marijana Andjic, Aleksandar Kocovic, Jasmina Sretenovic, Slobodanka Mitrovic, Biljana Bozin, Nebojsa Kladar, Sergey Bolevich, Jovana Bradic
Summary: Although oral ulcers are common oral mucosal diseases, the available treatment options are limited and may come with side-effects. This study developed a mucoadhesive oral gel based on Galium verum ethanol extract and investigated its healing effects on oral ulcers in rats. The results showed that the gel significantly reduced ulcer size, potentially through alleviating oxidative stress, reducing inflammation, and increasing collagen content in the affected tissue.
Article
Hematology
Biljana Zlojutro, Milka Jandric, Danica Momcicevic, Sasa Dragic, Tijana Kovacevic, Vlado Djajic, Milos P. Stojiljkovic, Ranko Skrbic, Dragan M. Djuric, Pedja Kovacevic
Summary: This study aims to analyze the dynamic changes in coagulation, hematological, and biochemical parameters in COVID-19 patients and their association with mortality. More research is needed to identify the most sensitive biomarkers as predictors of mortality. The study was a one-year-long observational study that included all critically ill COVID-19 patients with respiratory failure, and data on demographic, clinical, and laboratory parameters were collected. The results suggest that monitoring the abnormalities and dynamic changes in coagulation, hematological, and biochemical parameters can improve management and predict mortality in critically ill COVID-19 patients.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Cell Biology
Nevena Dragasevic, Maja Savic, Katarina Mihajlovic, Vladimir Zivkovic, Marijana Andjic, Nevena Draginic, Nebojsa Zdravkovic, Sergey Bolevich, Stefani Bolevich, Vladimir Jakovljevic, Tamara Nikolic Turnic
Summary: This study aimed to investigate the effects of various diuretics on the ischemia/reperfusion dysfunction of the heart in hypertensive rats. The results showed that treatment with hydrochlorothiazide, spironolactone, or indapamide reduced oxidative damage to the myocardium and mitigated left ventricular hypertrophy. However, there were no significant changes in blood pressure or ejection fraction. In addition, spironolactone had a cardiodepressant effect on spontaneously hypertensive rats.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zorislava Bajic, Tanja Sobot, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Mladen Duran, Nikolina Vesic, Sanja Avram, Sanja Jovicic, Maja Katana, Amela Matavulj, Nenad Ponorac, Dragan M. Djuric, Milos P. Stojiljkovic, Ranko Skrbic
Summary: This study aimed to investigate the cardioprotective effects of liraglutide, a GLP-1RA, on isoprenaline-induced myocardial injury in rats. The results showed that liraglutide mitigated cardiac dysfunction, reduced markers of myocardial injury, oxidative stress markers, and improved lipid profile.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ranko Skrbic, Maja Travar, Milos P. Stojiljkovic, Dragan M. Djuric, Relja Surucic
Summary: The interaction between the SARS-CoV-2 spike glycoprotein and the host-cell ACE2 receptor is a well-known step in virus infection, while neuropilin-1 (NRP-1) is another host factor involved in virus internalization. This study investigated the potential of folic acid and leucovorin as inhibitors of the S-glycoprotein/NRP-1 complex formation, and found that they showed promising results in preventing virus entry into host cells.
Article
Pharmacology & Pharmacy
Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition with a high prevalence in adults, children, and individuals with type 2 diabetes mellitus. It is a leading cause of liver-related morbidity and cardiovascular mortality. The use of nutraceuticals in managing NAFLD has been suggested, but there is currently insufficient evidence to support their routine use. Further rigorous trials are needed to evaluate their efficacy and safety.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sonja T. Marinkovic, Dorde Dukanovic, Mladen Duran, Zorislava Bajic, Tanja Sobot, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Zana M. Maksimovic, Ugljesa Malicevic, Nikolina Vesic, Sanja Jovicic, Maja Katana, Katarina Savikin, Dragan M. Djuric, Milos P. Stojiljkovic, Ranko Skrbic
Summary: The study found that pre-treatment with pomegranate peel extract can significantly attenuate isoprenaline-induced myocardial damage and achieve this effect by preserving endogenous antioxidant capacity.
Article
Physiology
Milica Gajic Bojic, Dorde Dukanovic, Sonja Marinkovic, Sanja Jovicic, Milos P. Stojiljkovic, Dragan M. Djuric, Ranko Skrbic
Summary: This study demonstrates that experimental protocols for measuring pathophysiological phenomena in the vascular responses of HUAs using vasoconstrictors and vasodilators can provide important insights for interpreting vascular effects. The findings suggest that serotonin is the most potent vasoconstrictor, while the role of homocysteine in impacting vascular responses deserves further investigation. Selective blockers also play a crucial role in understanding the mechanisms involved in the vascular effects of different substances on HUA preparations.
EXPERIMENTAL PHYSIOLOGY
(2023)