Review
Biochemistry & Molecular Biology
Federica Papaccio, Andrea D'Arino, Silvia Caputo, Barbara Bellei
Summary: Skin aging is characterized by fine lines, wrinkling, loss of elasticity and volume, and rough-textured appearance. The alteration of oxidative balance plays a key role in driving senescence, with reactive oxygen species (ROS) being produced through cellular oxidative metabolism and environmental factors causing loss of redox equilibrium. In addition to the structural changes, aging skin also loses its natural functional characteristics and regenerative potential. The skin immune system undergoes functional senescence, resulting in reduced ability to counteract infections and increased frequency of autoimmune and neoplastic diseases.
Review
Medicine, Legal
Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer
Summary: Research focused on providing quantitative dermal penetration data from 29 studies found that skin is an efficient barrier for nanoparticles, with only a small percentage penetrating the skin surface. The integrity of the skin layer and the product formulation are more critical factors for dermal penetration than the properties of the nanoparticles.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Virology
Nydia C. De la Cruz, Maureen Moeckel, Lisa Wirtz, Katharina Sunaoglu, Wolfram Malter, Max Zinser, Dagmar Knebel-Moersdorf
Summary: This study found that intact skin samples only allowed viral access from the edges, while HSV-1 efficiently invaded the basal layer of the epidermis and gained access to suprabasal layers. The expression of receptors nectin-1 and HVEM correlated with the susceptibility of all epidermal layers to HSV-1 infection. Interestingly, mechanical wounding did not facilitate HSV-1 entry via the skin surface, indicating that successful invasion of HSV-1 depends on reaching its receptors, which was not achieved by skin lesions under ex vivo conditions.
JOURNAL OF VIROLOGY
(2021)
Review
Medicine, General & Internal
Agata Zwara, Katarzyna Wertheim-Tysarowska, Adriana Mika
Summary: The skin is a flexible and dynamic organ that plays a crucial role in maintaining homeostasis and immune response, with lipids being key to this function. The epidermis, with its main lipids including cholesterol, fatty acids, and ceramides, possesses the best characteristics in this regard. Very long-chain fatty acids and ultra long-chain fatty acids are important components of ceramides, responsible for the rigidity and impermeability of cell membranes in the skin.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Sicheng Liu, Rui Guo, Hui Xu, Jinneng Yang, Haidan Luo, Sai-Ching Jim Yeung, Kai Li, Mong-Hong Lee, Runxiang Yang
Summary: 14-3-3s suppresses tumor progression by regulating HIF-1a stability and enhancing its degradation through NEDD4L-mediated poly-ubiquitination. Low expression levels of 14-3-3s are associated with poor survival in colorectal cancer patients, while 14-3-3s enhances the response of colorectal cancer to bevacizumab.
Article
Dermatology
Alec Sevilla, Jeremy Cheret, Wendy Lee, Ralf Paus
Summary: This pilot study aimed to investigate the effects of melatonin on melanin production and melanocytes in intact human epidermis. The results showed that melanin content and melanocyte dendricity increased with melatonin treatment, while tyrosinase activity was inhibited. Higher doses of melatonin increased the number and proliferation of melanocytes and keratinocytes, as well as the expression of the premelanosomal marker gp100. These findings suggest that long-term melatonin therapy may stimulate melanogenesis and increase the activity of epidermal melanocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Oliver J. Culley, Blaise Louis, Christina Philippeos, Benedicte Oules, Matthieu Tihy, Joe M. Segal, Della Hyliands, Gail Jenkins, Ranjit K. Bhogal, Richard C. Siow, Fiona M. Watt
Summary: Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We have identified IGF1 and WNT4 as candidate mediators of two distinct dermal functions: myofibroblast formation and epidermal maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Meng, Lan Feng, Jiali Shan, Zixu Yuan, Lin Jin
Summary: This study measured the epidermal and dermal thicknesses at different facial sites in healthy adults using high-frequency ultrasound, and found that gender, age, and BMI significantly influenced these thicknesses.
BMC MEDICAL IMAGING
(2022)
Review
Veterinary Sciences
Laurent Souci, Caroline Denesvre
Summary: The skin acts as a passive and active barrier to protect the body, and its health is crucial for fulfilling this role. The development of 3D skin models in humans has been facilitated by societal pressure to reduce animal experiments, allowing for more in-depth study and application of skin structure and functions.
VETERINARY RESEARCH
(2021)
Article
Biology
Melodi Yenmis, Yusuf Bayrakci, Dincer Ayaz
Summary: This study compares the scale microstructure of two snake species that occupy different ecological niches, and finds that microstructural features may be indicative of taxonomic relationship while pore number is negatively correlated with wettability.
Article
Veterinary Sciences
Piotr Kupczyk, Marta Rykala, Pawel Serek, Aleksandra Pawlak, Bartosz Slowikowski, Marcin Holysz, Grzegorz Chodaczek, Jan P. Madej, Piotr Ziolkowski, Artur Niedzwiedz
Summary: The study found that the distribution and cellular expression of cannabinoid receptors in the skin of horses under normal conditions were consistent and stable.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Fisheries
Lene Sveen, Gerrit Timmerhaus, Lill-Heidi Johansen, Elisabeth Ytteborg
Summary: An AI model was trained to detect multi-class segmentation of skin from Atlantic salmon and produced reliable spatial measurements of all the successive skin layers. The results were highly correlated to manual measurements and showed variations in skin tissue abundance at different body sites. The AI model was further used to evaluate skin samples from commercially farmed Atlantic salmon, revealing dynamic behavior of the skin related to time, life stage, and operational events.
Review
Dermatology
Mariane Massufero Vergilio, Silas Arandas Silva, Rodrigo Menezes Jales, Gislaine Ricci Leonardi
Summary: High-frequency ultrasound (HFUS) is a valuable technique in dermatology, providing real-time imaging of skin layers and lesions for diagnosis, management, and therapy monitoring. It is also useful for assessing the performance of dermatological products, which may become essential in the future.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomohisa Hirobe, Hisao Enami
Summary: This study suggests that elastin fibers may play an important role in the development and repigmentation of vitiligo. The results show that elastin fibers are decreased in vitiliginous skin and restored in repigmented skin after treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Shangshang Wang, Rui-Xing Yu, Wen Fan, Cheng-Xu Li, Wen-Min Fei, Shanshan Li, Junfeng Zhou, Ruiming Hu, Mengguo Liu, Feng Xu, Jinhua Xu, Yong Cui
Summary: High-frequency ultrasound (HFUS) provides a noninvasive method for evaluating the thickness and echo density of skin layers, showing significant variations in different anatomical sites, gender, age, and regions. This study has important implications for skin disease assessment, skin surgery, and cosmetology technology.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Critical Care Medicine
Abelardo Medina, Zengshuan Ma, Mathew Varkey, Hongbin Liu, Takashi Iwashina, Jie Ding, Edward E. Tredget
JOURNAL OF BURN CARE & RESEARCH
(2015)
Article
Cell & Tissue Engineering
Adam P. W. Johnston, Scott A. Yuzwa, Matthew J. Carr, Neemat Mahmud, Mekayla A. Storer, Matthew P. Krause, Karen Jones, Smitha Paul, David R. Kaplan, Freda D. Miller
Article
Critical Care Medicine
Abelardo Medina, Timothy Riegel, Deborah Nystad, Edward E. Tredget
JOURNAL OF BURN CARE & RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Matthew J. Carr, Yunyuan Li, Alireza Moeen Rezakhanlou, Aziz Ghahary
JOURNAL OF CELLULAR BIOCHEMISTRY
(2017)
Article
Surgery
Kevin J. Zuo, Abelardo Medina, Edward E. Tredget
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Critical Care Medicine
Abelardo Medina, Edward E. Tredget
JOURNAL OF BURN CARE & RESEARCH
(2013)
Article
Critical Care Medicine
Abelardo Medina, Heather Shankowsky, Bohdan Savaryn, Barb Shukalak, Edward E. Tredget
JOURNAL OF BURN CARE & RESEARCH
(2014)
Article
Cell & Tissue Engineering
Matthew J. Carr, Jeremy S. Toma, Adam P. W. Johnston, Patrick E. Steadman, Scott A. Yuzwa, Neemat Mahmud, Paul W. Frankland, David R. Kaplan, Freda D. Miller
Article
Surgery
Benjamin Googe, John Clayton Davidson, Peter B. Arnold, Abelardo Medina
ANNALS OF PLASTIC SURGERY
(2020)
Article
Neurosciences
Jeremy S. Toma, Konstantina Karamboulas, Matthew J. Carr, Adelaida Kolaj, Scott A. Yuzwa, Neemat Mahmud, Mekayla A. Storer, David R. Kaplan, Freda D. Miller
Article
Surgery
Ashley Tankersley, Ignacio Velasco Martinez, Abelardo Medina
CASE REPORTS IN PLASTIC SURGERY AND HAND SURGERY
(2020)
Article
Surgery
Narges Horriat, Tina R. Woods, Abelardo Medina
CASE REPORTS IN PLASTIC SURGERY AND HAND SURGERY
(2020)
Article
Surgery
Abelardo Medina, Ignacio Velasco Martinez
CASE REPORTS IN PLASTIC SURGERY AND HAND SURGERY
(2019)
Review
Neurosciences
Matthew J. Carr, Adam P. W. Johnston
CURRENT OPINION IN NEUROBIOLOGY
(2017)
Review
Surgery
Kate Elzinga, Abelardo Medina, Regan Guilfoyle
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2018)