Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 195, Issue 1, Pages 10-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2014.05.004
Keywords
Plasmodium; Mosquito stages; Plasmepsins; Aspartic proteases
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Funding
- DST [SR/SO/HS-122/2008]
- DBT
- Department of Biotechnology (DBT, India)
- Bioinformatics Infrastructure Facility (BIF) at ICGEB
- CSIR-CDRI
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Plasmepsins (PM), aspartic proteases of Plasmodium, comprises a family of ten proteins that perform critical functions in Plasmodium life cycle. Except VII and VIII, functions of the remaining plasmepsin members have been well characterized. Here, we have generated a mutant parasite lacking PM VII in Plasmodium berghei using reverse genetics approach. Systematic comparison of growth kinetics and infection in both mosquito and vertebrate host revealed that PM VII depleted mutants exhibited no defects in development and progressed normally throughout the parasite life cycle. These studies suggest a dispensable role for PM VII in Plasmodium berghei life cycle. (C) 2014 Elsevier B.V. All rights reserved.
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