Multimolecular Analysis of Stable Immunological Synapses Reveals Sustained Recruitment and Sequential Assembly of Signaling Clusters

Signals and Sequences That Control CD28 Localization to the Central Region of the Immunological Synapse

(2014) M. Sanchez-Lockhart et al.   JOURNAL OF IMMUNOLOGY

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

(2012) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET

(2012) M. H. Pauker et al.   Science Signaling

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms

(2011) S. Anand et al.   BLOOD

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

(2011) Rémi Lasserre et al.   JOURNAL OF CELL BIOLOGY

High-resolution imaging of the immunological synapse and T-cell receptor microclustering through microfabricated substrates

(2011) M. J. P. Biggs et al.   Journal of the Royal Society Interface

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

(2011) David J Williamson et al.   NATURE IMMUNOLOGY

Induction of BALT in the absence of IL-17

(2011) Henrike Fleige et al.   NATURE IMMUNOLOGY

4D Super-Resolution Microscopy with Conventional Fluorophores and Single Wavelength Excitation in Optically Thick Cells and Tissues

(2011) David Baddeley et al.   PLoS One

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

(2011) K. Adachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses

(2011) N. R. Sylvain et al.   Science Signaling

A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling

(2010) Julian Storim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters

(2010) Takashi Saito et al.   FEBS LETTERS

Essential Role of Ubiquitin and TSG101 Protein in Formation and Function of the Central Supramolecular Activation Cluster

(2010) Santosha Vardhana et al.   IMMUNITY

p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor

(2010) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma

(2010) Uta Berndt et al.   Molecular Cancer

Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3  in the endosomal compartment

(2010) I. A. Yudushkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

(2010) M. A. Purbhoo et al.   Science Signaling

Fully Integrated Microfluidic Platform Enabling Automated Phosphoprofiling of Macrophage Response

(2009) Nimisha Srivastava et al.   ANALYTICAL CHEMISTRY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Serum-derived MHC class II molecules: Potent regulators of the cellular and humoral immune response

(2009) Sardis Marios-Frankiskos et al.   IMMUNOBIOLOGY

Analysis of novel phospho-ITAM specific antibodies in a S2 reconstitution system for TCR–CD3 signalling

(2009) Elaine P. Dopfer et al.   IMMUNOLOGY LETTERS

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells

(2009) J. Horn et al.   JOURNAL OF IMMUNOLOGY

Toponome Mapping in Prostate Cancer: Detection of 2000 Cell Surface Protein Clusters in a Single Tissue Section and Cell Type Specific Annotation by Using a Three Symbol Code

(2009) Walter Schubert et al.   JOURNAL OF PROTEOME RESEARCH

Toponomics Analysis of Drug-Induced Changes in Arachidonic Acid-Dependent Signaling Pathways during Spinal Nociceptive Processing

(2009) Bona Linke et al.   JOURNAL OF PROTEOME RESEARCH

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Dazap2 modulates transcription driven by the Wnt effector TCF-4

(2009) Jan Lukas et al.   NUCLEIC ACIDS RESEARCH

Cluster size regulates protein sorting in the immunological synapse

(2009) N. C. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy

(2009) B. H. Hosseini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

(2009) A. Saveliev et al.   Science Signaling

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

The Balance between T Cell Receptor Signaling and Degradation at the Center of the Immunological Synapse Is Determined by Antigen Quality

(2008) Sašo Čemerski et al.   IMMUNITY

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) during Spinal Nociceptive Processing

(2008) Sandra Pierre et al.   MOLECULAR & CELLULAR PROTEOMICS

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA