Article
Immunology
Tomohisa Uchida, Kunihiro Ichinose, Ayuko Yamashita, Kumiko Muta, Mineaki Kitamura, Shuntaro Sato, Naoki Iwamoto, Tomoya Nishino, Atsushi Kawakami
Summary: This study evaluated the usefulness of renal risk score (RRS) in Japanese patients with ANCA-associated glomerulonephritis (AAGN) and found it to be a stable predictor of renal survival in such patients. The predictive value of RRS was comparable to the histological classification for predicting end-stage renal disease (ESRD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Charlotte Boud'hors, Marie Christine Copin, Samuel Wacrenier, Giorgina Barbara Piccoli, Anne Croue, Jean-Francois Augusto, Benoit Brilland
Summary: This article discusses the prognostic value of renal lesions at the diagnosis of ANCA-GN, reviews the existing ESKD risk classification in ANCA-GN, and proposes an example of a standardized pathology report that could be used in routine practice.
AUTOIMMUNITY REVIEWS
(2022)
Article
Immunology
Charlotte Boud'hors, Marie Christine Copin, Samuel Wacrenier, Giorgina Barbara Piccoli, Anne Croue, Jean-Francois Augusto, Benoit Brilland
Summary: Anti-neutrophil cytoplasmic antibody-associated vasculitis is associated with renal involvement and assessing the renal prognosis through kidney biopsy is crucial.
AUTOIMMUNITY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Juan Irure-Ventura, Lara Belmar-Vega, Gema Fernandez-Fresnedo, Elena Gonzalez-Lopez, Carolina Castro-Hernandez, Emilio Rodrigo-Calabia, Milagros Heras-Vicario, Juan Carlos Ruiz San Millan, Marcos Lopez-Hoyost
Summary: An increase in the development of ANCA-associated vasculitis (AAV) has been observed in 2021, with most cases occurring after SARS-CoV-2 vaccination, particularly the second dose. The kidneys and respiratory tracts are the main organs affected.
Article
Multidisciplinary Sciences
Jennifer Scott, Carolina Canepa, Antonia Buettner, Louise Ryan, Brona Moloney, Sarah Cormican, Cathal Walsh, Arthur White, Alan D. Salama, Mark A. Little
Summary: Sex does not have a strong impact on renal outcomes in patients with ANCA-associated vasculitis glomerulonephritis (ANCA-GN), and treatment intensity does not vary by sex.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Salem Almaani, Lynn A. Fussner, Sergey Brodsky, Alexa S. Meara, David Jayne
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. AAV involves multiple organ systems clinically, including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has significantly improved due to advances in understanding its pathogenesis and treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Idris Boudhabhay, Florence Delestre, Guillaume Coutance, Viviane Gnemmi, Thomas Quemeneur, Cyrille Vandenbussche, Helene Lazareth, Guillaume Canaud, Leila Tricot, Clement Gosset, Aurelie Hummel, Benjamin Terrier, Marion Rabant, Emma E. van Daalen, Maria A. C. Wester Trejo, Ingeborg M. Bajema, Alexandre Karras, Jean-Paul Duong Van Huyen
Summary: In patients with AAV and renal involvement, arteritis of small kidney arteries is associated with worse outcomes and has specific clinical and histologic characteristics. The presence of arteritis independently predicts end-stage kidney disease and significantly improves the discriminative ability of the ANCA renal risk score. Confirmation of these findings in external validation cohorts is necessary to further establish the prognostic contribution of arteritis status.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Muhammad Tariq Shakoor, Mark P. Birkenbach, Matthew Lynch
Summary: Severe acute respiratory syndrome coronavirus 2 (SAR S-CoV-2) is still spreading worldwide, driving the largest vaccination campaign in human history. Although the vaccines have been found to be safe and effective, rare side effects continue to arise. A case of new-onset renal-limited ANCA-associated vasculitis (AAV) in a 78-year-old woman post Pfizer-BioNTech COVID-19 vaccination highlights the need for ongoing surveillance for similar complications.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Urology & Nephrology
Jeong-Hoon Lim, Man-Hoon Han, Yong-Jin Kim, Yena Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Hajeong Lee, Dong Ki Kim, Kyung Chul Moon, Sun-Hee Park
Summary: In Korean AAGN patients, histopathologic and clinicopathologic classifications have predictive value for renal outcomes, especially in the sclerotic class or the high-risk group with higher risk of progression to end-stage kidney disease despite treatment.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Urology & Nephrology
Marta Calatroni, Filippo Consonni, Marco Allinovi, Alessandra Bettiol, Natasha Jawa, Susanna Fiasella, Dritan Curi, Sarah Abu-Rumeileh, Leonardo Tomei, Laura Fortunato, Elena Gelain, Davide Gianfreda, Elena Oliva, Guido Jeannin, Chiara Salviani, Giacomo Emmi, Monica Bodria, Renato Sinico, Gabriella Moroni, Giuseppe A. Ramirez, Enrica Bozzolo, Enrico Tombetti, Sara Monti, Claudia Bracaglia, Giulia Marucci, Serena Pastore, Pasquale Esposito, Maria Catanoso, Barbara Crapella, Giovanni Montini, Rosa Roperto, Marco Materassi, Giovanni Rossi, Salvatore Badalamenti, Rae Yeung, Paola Romagnani, Gian Marco Ghiggeri, Damien Noone, Augusto Vaglio
Summary: In children with ANCA-associated kidney vasculitis, microscopic polyangiitis and granulomatosis with polyangiitis are the most common types. Patients often present with rapidly progressive GN and nephrotic-range proteinuria. Those with sclerotic histology on kidney biopsy have shorter kidney survival and poorer prognosis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Pei Zhang, Jun Yao, Chun-lin Gao, Xiang Fang, Zhi-qiang Zhang, Zheng-kun Xia
Summary: This study investigated the value of ANCA renal risk score (ARRS) in predicting renal prognosis among Chinese children with ANCA-associated glomerulonephritis (AAGN). The findings showed that ARRS was able to predict end stage kidney disease (ESKD) in these children, with the high-risk group having poorer renal outcomes. Furthermore, eGFR ≤ 15 ml/min/1.73 m² and ARRS were identified as independent risk factors for ESKD.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Immunology
Benoit Brilland, Charlotte Boud'hors, Marie-Christine Copin, Pierre Jourdain, Nicolas Henry, Samuel Wacrenier, Assia Djema, Clement Samoreau, Jean-Philippe Coindre, Maud Cousin, Jeremie Riou, Anne Croue, Jean-Paul Saint-Andre, Jean-Francois Subra, Giorgina Barbara Piccoli, Jean-Francois Augusto
Summary: This study analyzed the value of Renal Risk Score (RRS) and histopathological classification in predicting the risk of end-stage kidney disease (ESKD) in ANCA-associated glomerulonephritis (ANCA-GN). It also found that eGFR at ANCA-GN diagnosis was the main determinant of eGFR variation within the first 2 years.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kim M. O'Sullivan, Stephen R. Holdsworth
Summary: Understanding the role of cell death in autoimmune diseases can help define critical pathways in immunopathogenesis and identify new therapeutic targets. Neutrophils, crucial immune responder cells, play important roles in diseases like MPO-ANCA Microscopic Vasculitis in both host defense and autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sung-Eun Choi, Soo Bin Lee, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Beom Jin Lim, Sang-Won Lee
Summary: This study investigated the predictive value of histopathological classification and histologic lesion scores in the progression to end-stage kidney disease (ESKD) in patients with ANCA-associated vasculitis-glomerulonephritis (AAV-GN). The study found that a high global glomerulitis score was an independent predictor of ESKD progression, and the sclerotic class had the worst renal prognosis among the histopathological classes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Adam D. Morris, Daniel L. D. Freitas, Kassio M. G. Lima, Lauren Floyd, Mark E. Brady, Ajay P. Dhaygude, Anthony W. Rowbottom, Francis L. Martin
Summary: This study evaluated the application of machine learning and Raman spectroscopy for the automated computational detection of disease activity in ANCA-associated glomerulonephritis. The results showed that spectral data from tissue samples were able to accurately discriminate disease activity, while corresponding spectrochemical changes in paired urine samples were limited.