Article
Oncology
Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolanos, Inmaculada Rodriguez, Inaki Etxeberria, Assunta Cirella, Josune Egea, Saray Garasa, Itziar Migueliz, Inaki Eguren-Santamaria, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Beatrice Malacrida, David Propper, Carlos E. de Andrea, Pedro Berraondo, Frances R. Balkwill, Alvaro Teijeira, Ignacio Melero
Summary: In the tumor microenvironment, IL-8 correlates with poor response to checkpoint inhibitors and attracts immunosuppressive myeloid cells. TNF alpha and IL-1 beta are major inducers of IL-8 expression on malignant cells, which can be interfered with by clinically available neutralizing agents.
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoming Li, Fang Li, Xixi Zhang, Haiwei Zhang, Qun Zhao, Ming Li, Xiaoxia Wu, Lingxia Wang, Jianling Liu, Xuanhui Wu, Yangjing Ou, Mingyan Xing, Yue Zhang, Jiangshan Deng, Xiuzhe Wang, Yan Luo, Jinbao Li, Yuwu Zhao, Haibing Zhang
Summary: This study reveals the important role of caspase-8 auto-cleavage in regulating necroptosis and maintaining lymphocyte homeostasis.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Xin Li, Hao Zhang, Yong Wang, Yanyan Li, Yan Xiong, Ruiwen Li, Jiangjiang Zhu, Yaqiu Lin
Summary: This study focused on the molecular and expression characteristics of the goat STEAP4 gene, and explored its influence on the differentiation of goat subcutaneous adipocytes through overexpression. The results showed that overexpression of STEAP4 promoted the differentiation of goat subcutaneous preadipocytes.
ARCHIVES ANIMAL BREEDING
(2022)
Article
Medicine, General & Internal
Manabu Mukai, Kentaro Uchida, Tadashi Okubo, Shotaro Takano, Toshihide Matsumoto, Masashi Satoh, Gen Inoue, Masashi Takaso
Summary: The peptide Lv suppresses inflammatory cytokine production in bone marrow macrophages and plays a key role in synovial inflammation, indicating it may be a potential therapeutic target for synovitis.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lekha Rani, Anil Kumar, Juilee Karhade, Garima Pandey, Adrita Guha, Gyan C. Mishra, Mohan R. Wani
Summary: IL-3 inhibits the differentiation of Th17 cells and promotes the development of Treg cells, regulating the pathogenesis of rheumatoid arthritis. IL-3 treatment significantly decreases the pathogenic Th17 cell responses and arthritic scores.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Stephen T. Yeung, Luis J. Ovando, Ashley J. Russo, Vijay A. Rathinam, Kamal M. Khanna
Summary: Macrophages play important roles in regulating pathogen clearance and immune homeosta-sis in tissues. The functional diversity of macrophage subsets depends on tissue environment and the nature of the pathological insult. CD169+ macrophage subsets are crucial for protection under excessive inflammatory conditions. They control inflammatory responses via interleukin-10 (IL-10) and may serve as a potential therapeutic target under damaging inflammatory conditions.
Article
Multidisciplinary Sciences
Carolina Manosalva, Pablo Alarcon, John Quiroga, Stefanie Teuber, Maria D. Carretta, Hedie Bustamante, Rodrigo Lopez-Munoz, Maria A. Hidalgo, Rafael A. Burgos
Summary: Lameness in dairy cattle can be caused by infectious or noninfectious agents, with joint lesions being the second most common cause. Fibroblast-like synoviocytes (FLS) play a key role in joint diseases and the expression of proinflammatory mediators. Tumor necrosis factor-alpha (TNF-alpha) is a potent proinflammatory cytokine that increases the expression of proinflammatory cytokines in bovine FLS (bFLS). This study found that TNF-alpha induces metabolic reprogramming in bFLS, favoring glycolysis, and increasing the expression of IL-6, IL-8, IL-1 beta, and COX-2/PGE2.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Elisa Gremese, Barbara Tolusso, Dario Bruno, Simone Perniola, Gianfranco Ferraccioli, Stefano Alivernini
Summary: Despite advances in understanding the molecular and cellular taxonomy of synovial membranes in rheumatoid arthritis (RA), a proportion of patients do not respond to current treatments. In this review, we discuss the role of IL-8 and IL-17 in promoting inflammation in multiple biological compartments and how targeting them could improve treatment resistance.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ting Lin, Xu Bai, Yuan Gao, Bohao Zhang, Jun Shi, Bao Yuan, Wenli Chen, Jianfu Li, Yong Zhang, Quanwei Zhang, Xingxu Zhao
Summary: In this study, a cell model of inflammatory mammary cells was established and it was found that Cystathionine-gamma-lyase (CTH) and hydrogen sulfide (H2S) play important roles in the progression of Clinical Mastitis (CM) in Holstein cows. Inhibition of CTH/H2S promoted inflammation, but H2S protected cells from inflammatory damage. The interleukin-8 (IL-8) signaling was identified to mediate the anti-inflammatory effects of CTH/H2S.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jinhai He, Li Wang, Yajun Ding, Hongbing Liu, Guoyou Zou
Summary: The study investigated the expression of lncRNA FER1L4 in OA and its potential as a diagnostic marker. The results showed that FER1L4 was downregulated in OA patients and could efficiently discriminate OA cases from normal subjects. Additionally, upregulation of FER1L4 inhibited IL-6 expression in human chondrocytes.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. K. Singh
Summary: Vascular adhesion molecules, specifically VCAM-1, have been found to play a crucial role in retinal neovascularization and can be regulated by IL-33. The study also highlights the regulatory role of VCAM-1-JunB-IL-8 signaling in retinal endothelial cell sprouting and angiogenesis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, General & Internal
Weronika Pawlik, Jakub Pawlik, Mateusz Kozlowski, Karolina Luczkowska, Sebastian Kwiatkowski, Ewa Kwiatkowska, Boguslaw Machalinski, Aneta Cymbaluk-Ploska
Summary: This study found that serum levels of IL-8 and TNF-alpha were significantly higher in ovarian cancer patients compared to patients with benign ovarian cysts, and they can be used as new useful markers for predicting ovarian cancer. IL-8 and TNF-alpha have a sensitivity and specificity of 70% and 96%, and 85.7% and 79.3% respectively, indicating their utility in predicting the malignant nature of ovarian lesions.
Article
Biochemistry & Molecular Biology
Yu-mei Zhong, Lin-lin Zhang, Wen-ting Lu, Ya-nan Shang, Hai-yan Zhou
Summary: This study observed the effects of moxibustion on rat models of rheumatoid arthritis (RA) at the acupoints of Shenshu and Zusanli, and explored its possible anti-inflammatory mechanism. The results showed that moxibustion treatment improved the symptoms of RA, reduced the inflammatory markers, and improved the histological characteristics. Furthermore, moxibustion regulated the polarization of macrophages and exerted its anti-inflammatory effects through inhibiting the IL-4/STAT6 signaling pathway.
